Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling

Martín, Abraham; Domercq, Marı́a; Matute, Carlos

doi:10.1177/1756286418774267

Cited by 32 publications

(19 citation statements)

References 111 publications

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“…Inflammation of the nervous system (termed neuroinflammation) has been shown to play a pivotal role in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, traumatic brain injury, and stroke. 3 – 5 What has emerged more recently is that diseases that were largely thought to be based on dysregulation of neurotransmitter systems such as mood disorders (including depression and anxiety), schizophrenia, and chronic pain now appear to have neuroinflammation as a key element (reviewed in Skaper et al 4 ).…”

Section: Overview Of Neuroinflammationmentioning

confidence: 99%

An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain

Lurie

2018

J Exp Neurosci

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Neuroinflammation is a complex process involving both the peripheral circulation and the Central Nervous System (CNS) and is considered to underlie many CNS disorders including depression, anxiety, schizophrenia, and pain. Stressors including early-life adversity, psychosocial stress, and infection appear to prime microglia toward a pro-inflammatory phenotype. Subsequent inflammatory challenges then drive an exaggerated neuroinflammatory response involving the upregulation of pro-inflammatory mediators that is associated with CNS dysfunction. Several pharmacologic inhibitors of pro-inflammatory cytokines including TNF-α and IL-1β show good clinical efficacy in terms of ameliorating neuroinflammatory processes. Mind/body and plant-based interventions such as yoga, breathing exercises, meditation, and herbs/spices have also been demonstrated to reduce pro-inflammatory cytokines and have a positive impact on depression, anxiety, cognition, and pain. As the intricate connections between the immune system and the nervous system continue to be elucidated, successful therapies for reducing neuroinflammation will likely involve an integrated approach combining drug therapy with nonpharmacologic interventions.

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Section: Overview Of Neuroinflammationmentioning

confidence: 99%

An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain

Lurie

2018

J Exp Neurosci

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“…In tandem, there is a cascade of inflammatory pathways upregulating pro-inflammatory cytokine production, all of which in turn activating various cell death signals for necrosis and programed cell death. Of note, recent studies have demonstrated the involvement of neurotransmitter signaling in the modulation of neuroinflammation [ 77 ]. Hence, further studies that investigate the role of the inflammation-associated vasculome and purinergic signaling in ischemic stroke is essential.…”

Section: Discussionmentioning

confidence: 99%

Endothelial Progenitor Cells Modulate Inflammation-Associated Stroke Vasculome

Acosta

Lee

Nguyen

et al. 2019

Stem Cell Rev and Rep

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Stroke remains a major unmet clinical need that warrants novel therapies. Following an ischemic insult, the cerebral vasculature secretes inflammatory molecules, creating the stroke vasculome profile. The present study evaluated the therapeutic effects of endothelial cells on the inflammation-associated stroke vasculome. qRT-PCR analysis revealed that specific inflammation-related vasculome genes BRM, IκB, Foxf1, and ITIH-5 significantly upregulated by oxygen glucose deprivation (OGD. Interestingly, co-culture of human endothelial cells (HEN6) with human endothelial cells (EPCs) during OGD significantly blocked the elevations of BRM, IκB, and Foxf1, but not ITIH-5. Next, employing the knockdown/antisense technology, silencing the inflammation-associated stroke vasculome gene, IκB, as opposed to scrambled knockdown, blocked the EPC-mediated protection of HEN6 against OGD. In vivo, stroke animals transplanted with intracerebral human EPCs (300,000 cells) into the striatum and cortex 4 h post ischemic stroke displayed significant behavioral recovery up to 30 days post-transplantation compared to vehicle-treated stroke animals. At 7 days post-transplantation, quantification of the fluorescent staining intensity in the cortex and striatum revealed significant upregulation of the endothelial marker RECA1 and a downregulation of the stroke-associated vasculome BRM, IKB, Foxf1, ITIH-5 and PMCA2 in the ipsilateral side of cortex and striatum of EPC-transplanted stroke animals relative to vehicle-treated stroke animals. Altogether, these results demonstrate that EPCs exert therapeutic effects in experimental stroke possibly by modulating the inflammation-plagued vasculome.

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“…158 Several complex cascades of processes in early stroke are influenced by afferent and efferent pathways of the vagus nerve. 159 VNS is a potential tool for subacute stroke recovery owing to its anti-inflammatory and neuromodulators releasing properties. 160,161 Invasive VNS is normally 0.25 to 3 mA, equipped with bipolar electrodes placed underneath the chest skin and the left vagus nerve.…”

Section: Vagus Nerve Stimulationmentioning

confidence: 99%

Rewiring the Lesioned Brain: Electrical Stimulation for Post-Stroke Motor Restoration

et al. 2020

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Electrical stimulation has been extensively applied in post-stroke motor restoration, but its treatment mechanisms are not fully understood. Stimulation of neuromotor control system at multiple levels manipulates the corresponding neuronal circuits and results in neuroplasticity changes of stroke survivors. This rewires the lesioned brain and advances functional improvement. This review addresses the therapeutic mechanisms of different stimulation modalities, such as noninvasive brain stimulation, peripheral electrical stimulation, and other emerging techniques. The existing applications, the latest progress, and future directions are discussed. The use of electrical stimulation to facilitate post-stroke motor recovery presents great opportunities in terms of targeted intervention and easy applicability. Further technical improvements and clinical studies are required to reveal the neuromodulatory mechanisms and to enhance rehabilitation therapy efficiency in stroke survivors and people with other movement disorders.

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Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling

Cited by 32 publications

References 111 publications

An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain

An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain

Endothelial Progenitor Cells Modulate Inflammation-Associated Stroke Vasculome

Rewiring the Lesioned Brain: Electrical Stimulation for Post-Stroke Motor Restoration

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