Inflammation in low back pain may be detected from the peripheral blood: suggestions for biomarker

Abstract

The results of our study provides novel insights into the mechanisms of low back pain, as well as provide suggestions of the possibility that these assays may be used as biomarkers for low back pain.

Uneven intervertebral motion sharing is related to disc degeneration and is greater in patients with chronic, non-specific low back pain: an in vivo, cross-sectional cohort comparison of intervertebral dynamics using quantitative fluoroscopy

“…Circulating inflammatory markers have been found in such patients [46] and it may be hypothesised that the greater the unevenness of motion sharing, the greater the likely prevalence of rapid displacements during physical tasks causing the release of cytokines from failing holding elements.…”

Signs of ongoing inflammation in female patients with chronic widespread pain

“…[47–49] Cytokines can be divided into proinflammatory and anti-inflammatory cytokines, and many different cytokines have been investigated in FMS (Rodiguez-Pinto et al). [25] Increased serum levels of IL-6 and IL-8 have been reported in several studies of FMS.…”

Burst Spinal Cord Stimulation Increases Peripheral Antineuroinflammatory Interleukin 10 Levels in Failed Back Surgery Syndrome Patients With Predominant Back Pain

“…Human and preclinical model studies have observed a possible correlation between the back pain of intervertebral disc degeneration and pro‐/anti‐inflammatory mediators in different bio‐fluids (CSF/blood) .…”

“…There is accumulating clinical and experimental evidence confirming the existence of potent, adaptive interactions between the central and peripheral aspects of the Neuro‐immune System in the genesis and maintenance of chronic neuropathic and nociceptive back pain . The neuro‐inflammatory pathway is modulated by the interaction of pro‐ and anti‐inflammatory cytokines and chemokines, and peripheral immune system‐derived cells (macrophages, leukocytes).…”