Inflammation in acne scarring: a comparison of the responses in lesions from patients prone and not prone to scar

Holland, D.B.; Jeremy, Anthony H T; Roberts, Susan G.; Seukeran, D.C.; Layton, Alison; Cunliffe, W.J.

doi:10.1111/j.1365-2133.2004.05749.x

Cited by 153 publications

(139 citation statements)

References 24 publications

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“…In the majority of patients, the clinical picture is characterized by the infl ammatory/immunological disease component. In severe cases (conglobate acne), follicular rupture causes foreign body reactions to comedonal components (corneocytes, hairs) ( Figure 1 [ 4 ] . Less severe disease courses, too, may result in scarring.…”

Section: Clinical Presentationmentioning

confidence: 99%

Acne

Degitz

Ochsendorf

2017

J Deutsche Derma Gesell

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Summary Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF‐1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life. Effective topical and systemic treatments are available. Optimal therapeutic results require continuous patient management over the course of the entire treatment period as well as adjustment of treatment modalities based on symptoms and disease severity.

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Section: Clinical Presentationmentioning

confidence: 99%

Acne

Degitz

Ochsendorf

2017

J Deutsche Derma Gesell

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“…Scarring acne shows a predominantly CD45RO+memory T cell immune response, which is initially small and ineffective, but later becomes increased and activated in resolving lesions. In contrast with non-scarring acne, the cellular infiltrate is large and active with few memory T cells in early lesion, which subsides in the resolution phase [3].…”

Section: Pathophysiology Of Scar Formationmentioning

confidence: 90%

Scar Treatment with Lasers: A Review and Update

Harithy

Pon

2012

Curr Derm Rep

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“…Holland et al observed that in inflammatory lesions from patients who have less scarring, there is a brisk inflammatory cellular infiltrate composed of T-helper lymphocytes, macrophages, and Langerhans cells, with accompanying angiogenesis that quickly resolves compared with patients who are prone to scarring, where the inflammation and angiogenesis start slowly but is maintained over a longer period. It is speculated that the prolonged inflammatory response in patients prone to scarring is a delayed-type hypersensitivity reaction to persistent antigenic stimulus that they were initially unable to eliminate [36]. As there is no tool to predict who will develop this delayed-type reaction, treating early inflammation is the best approach to prevent acne scarring.…”

Section: Inflammatory Responsesmentioning

confidence: 99%

Acne Vulgaris

Kutlubay¹,

Keçici²,

Engın³

et al. 2017

Acne and Acneiform Eruptions

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Acne vulgaris is a multifactorial disorder of the pilosebaceous unit. The clinical picture can range from mild comedones to fulminant, scarring cases. Approximately 83-100% of all adolescents experience acne vulgaris at some point of their lives. Although acne often tends to resolve following the adolescent period, many men and women continue to suffer from either active acne or postinflammatory scars into their twenties and thirties. Most patients with acne vulgaris are in the complicated adolescence period and thus carry a distinctive psychosocial burden. They possess a disease stigma on their skin for the external world to criticize every day. For all these reasons, acne is a disease which should be treated promptly and efficiently in all age groups. This chapter will provide a comprehensive and up-to-date review of pathophysiology of acne vulgaris, new molecular mechanisms on the evolving acne lesions, epidemiology of the disease, and latest treatment options. The molecular biology of acne lesions, novel treatment options including cosmetic approaches, their role in acne pathogenesis, pathophysiology, and mechanism of actions of the drugs, safety, and efficacy issues, and various treatment regimens will be discussed along with novel discoveries and areas in which further research is needed.

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Inflammation in acne scarring: a comparison of the responses in lesions from patients prone and not prone to scar

Cited by 153 publications

References 24 publications

Acne

Acne

Scar Treatment with Lasers: A Review and Update

Acne Vulgaris

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