Inflammation et régénération musculaire

Dufresne, Sébastien S.; Frenette, Jérôme; Dumont, Nicolas A.

doi:10.1051/medsci/20163206022

Cited by 13 publications

(11 citation statements)

References 45 publications

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“…After acute (reversible) injury, skeletal muscle has a remarkable capacity to initiate a rapid and extensive regeneration, which is always associated with an inflammatory reaction that varies in intensity [64]. Evidence points out that a controlled and efficient inflammation is necessary for an optimal muscle recovery [65]. Regeneration of skeletal muscle also depends on muscle stem cells, named satellite cells, which are kept in a quiescent state in a healthy muscle [64].…”

Section: Pro-myogenic Effectsmentioning

confidence: 99%

“…As gApN expression is low in the bloodstream, it is likely that most gApN is locally produced by muscle (satellite cells, differentiating myoblasts, ..) and acts in an autocrine or paracrine manner as a tissue regenerating hormone [66]. Both M1 macrophages and gApN play essential roles in the activation of satellite cells and the initiation of muscle regeneration [65,66]. Once activated, satellite cells will migrate, proliferate and give rise to myoblasts that differentiate into myotubes, which then fuse to restore damaged fibers or generate new one [64] (Figure 3).…”

Section: Pro-myogenic Effectsmentioning

confidence: 99%

“…Once activated, satellite cells will migrate, proliferate and give rise to myoblasts that differentiate into myotubes, which then fuse to restore damaged fibers or generate new one [64] (Figure 3). optimal muscle recovery [65]. Regeneration of skeletal muscle also depends on muscle stem cells, named satellite cells, which are kept in a quiescent state in a healthy muscle [64].…”

Section: Pro-myogenic Effectsmentioning

confidence: 99%

“…Meanwhile, ApN enhances PGC-1α expression and activity, which promotes oxidative metabolism to respond to the high energy demand for sustaining tissue-healing and regeneration [74]. Thus, controlled accumulation of immune cells and increased energy metabolism are essential for appropriate muscle tissue remodeling [65] (Figure 3).…”

Section: Pro-myogenic Effectsmentioning

confidence: 99%

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Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?

Abou‐Samra

Selvais

Dubuisson

et al. 2020

IJMS

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Adiponectin (ApN) is a hormone abundantly secreted by adipocytes and it is known to be tightly linked to the metabolic syndrome. It promotes insulin-sensitizing, fat-burning, and anti-atherosclerotic actions, thereby effectively counteracting several metabolic disorders, including type 2 diabetes, obesity, and cardiovascular diseases. ApN is also known today to possess powerful anti-inflammatory/oxidative and pro-myogenic effects on skeletal muscles exposed to acute or chronic inflammation and injury, mainly through AdipoR1 (ApN specific muscle receptor) and AMP-activated protein kinase (AMPK) pathway, but also via T-cadherin. In this review, we will report all the beneficial and protective properties that ApN can exert, specifically on the skeletal muscle as a target tissue. We will highlight its effects and mechanisms of action, first in healthy skeletal muscle including exercised muscle, and second in diseased muscle from a variety of pathological conditions. In the end, we will go over some of AdipoRs agonists that can be easily produced and administered, and which can greatly mimic ApN. These interesting and newly identified molecules could pave the way towards future therapeutic approaches to potentially prevent or combat not only skeletal muscle disorders but also a plethora of other diseases with sterile inflammation or metabolic dysfunction.

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Section: Pro-myogenic Effectsmentioning

confidence: 99%

Section: Pro-myogenic Effectsmentioning

confidence: 99%

Section: Pro-myogenic Effectsmentioning

confidence: 99%

Section: Pro-myogenic Effectsmentioning

confidence: 99%

See 2 more Smart Citations

Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?

Abou‐Samra

Selvais

Dubuisson

et al. 2020

IJMS

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“…Grâce à sa structure, la dystrophine permet le maintien de l'architecture et de l'intégrité des fibres musculaires. L'absence de dystrophine dans les fibres musculaires de patients DMD entraîne consécutivement la nécrose primaire des fibres, suivie de l'infiltration chronique de cellules inflammatoires et de l'accumulation de fibrose et de tissu adipeux intramusculaire [3] …”

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Déficits intrinsèques des cellules satellites dans la dystrophie musculaire de Duchenne

Brun

Dumont

2016

Med Sci (Paris)

Self Cite

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Prevalence and long-term monitoring of humoral immunity against adeno-associated virus in Duchenne Muscular Dystrophy patients

Leborgne

Latournerie

Boutin

et al. 2019

Cellular Immunology

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Adeno-associated virus (AAV) vectors are promising candidates for gene therapy and have been explored as gene delivery vehicles in the treatment of Duchenne Muscular Dystrophy (DMD). Recent studies showed compelling evidence of therapeutic efficacy in large animal models following the intravenous delivery of AAV vectors expressing truncated forms of dystrophin. However, to translate these results to humans, careful assessment of the prevalence of anti-AAV neutralizing antibodies (NAbs) is needed, as presence of preexisting NABs to AAV in serum have been associated with a drastic diminution of vector transduction. Here we measured binding and neutralizing antibodies against AAV serotype 1, 2, and 8 in serum from children and young adults with DMD (n = 130). Results were compared with to age-matched healthy donors (HD, n = 113). Overall, approximately 54% of all subjects included in the study presented IgG to AAV2, 49% to AAV1, and 41% to AAV8. A mean of around 80% of IgG positive sera showed neutralizing activity with no statistical difference between DMD and HD. NAb titers for AAV2 were higher than AAV1, and AAV8 in both populations studied. Older DMD patients (13-24 years old) presented significantly lower anti-AAV8 IgG4 subclass. Anti-AAV antibodies were found to be decreased in DMD patients subjected to a 6-month course of corticosteroids and in subjects receiving a variety of immunosuppressive drugs including B cell targeting drugs. Longitudinal follow up of humoral responses to AAV over up to 6 years showed no change in antibody titers, suggesting that in this patient population, seroconversion is a rare event in humans.

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Inflammation et régénération musculaire

Cited by 13 publications

References 45 publications

Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?

Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?

Déficits intrinsèques des cellules satellites dans la dystrophie musculaire de Duchenne

Prevalence and long-term monitoring of humoral immunity against adeno-associated virus in Duchenne Muscular Dystrophy patients

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