Inflammation—Dysregulated inflammatory response and strategies for treatment

Herold, Kristina; Mrowka, Ralf

doi:10.1111/apha.13284

Cited by 16 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 1. 1 H and 13 C NMR data for 1-4 at 600 MHz and 150 MHz in CD3OD (δ in ppm, J in Hz), respectively. The planar structure of 1 was elucidated by detailed analysis of 1 H-1 H COSY and HMBC data.…”

Section: Structural Elucidationmentioning

confidence: 99%

“…Herein, we report the isolation, structure elucidation and anti-inflammatory activity of streptoglycerides E-H (1-4) (Figure 1). new derivatives of streptoglycerides (1)(2)(3)(4). Herein, we report the isolation, structure elucidation and anti-inflammatory activity of streptoglycerides E-H (1-4) (Figure 1).…”

Section: Introductionmentioning

confidence: 98%

“…Inflammation is a normal defense mechanism that occurs to cope with tissue damage and microbial infection [1]. When tissues are exposed to LPS, NO and cytokines such as interleukins (IL-6 and IL-1β), and tumor necrosis factor-α (TNF-α) are produced naturally [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…[16]. During our ongoing investigation of secondary metabolites from marine microorganisms, we encountered another strain, designated as Streptomyces specialis 208DD-067, isolated from a sediment sample collected off Dokdo, South Korea, which produced new derivatives of streptoglycerides (1)(2)(3)(4). Herein, we report the isolation, structure elucidation and anti-inflammatory activity of streptoglycerides E-H (1-4) (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium Streptomyces specialis and Their Anti-Inflammatory Activity

et al. 2022

View full text Add to dashboard Cite

Four new streptoglycerides E–H (1–4), with a rare 6/5/5/-membered ring system, were isolated from a marine-derived actinomycete Streptomyces specialis. The structures of 1–4 were elucidated by detailed analysis of HRESIMS, 1D and 2D NMR data and ECD spectra as well as comparison of their spectroscopic data with those reported in literature. Compounds 1–4 showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in Raw 264.7 cells with IC50 values ranging from 3.5 to 10.9 µM. Especially, 2 suppressed mRNA expression levels of iNOS and IL-6 without cytotoxicity.

show abstract

Section: Structural Elucidationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium Streptomyces specialis and Their Anti-Inflammatory Activity

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Inflammation is a normal protective response to infection, tissue damage, trauma, or harmful stimuli . However, excessive activation of macrophages causes marked damage to living organisms via the production and accumulation of pro-inflammatory chemicals .…”

Section: Introductionmentioning

confidence: 99%

Isolation, Identification, and Anti-Inflammatory Activity of Polysaccharides of Typha angustifolia

et al. 2021

View full text Add to dashboard Cite

The present study aimed to purify, structurally characterize, and evaluate the anti-inflammatory activity of the polysaccharide extracted from Typha angustifolia. Two purified polysaccharides (PTA-1 and PTA-2) were obtained via DEAE-52 cellulose chromatography. Their structural characterizations and antioxidant activity were in vitro analyzed. To evaluate the anti-inflammatory activity of PTA-2, the levels of inflammatory cytokines, intracellular ROS production, and the inhibitory effects of the transcriptional activation of the nuclear factor kappa B (NF-κB) signaling pathway were determined. PTA-1 comprises glucose (100%) with α-(1 → 3) glycosidic bonds, and PTA-2 comprises glucose (66.7%) and rhamnose (33.3%) formed by β-(1 → 3) glycosidic bonds. PTA-1 and PTA-2 showed strong antioxidant activity in vitro. Moreover, PTA-2 intervention (50, 100, and 200 μg/mL) suppressed the production of inflammatory cytokines, the activation of NF-κB signaling, and reactive oxygen species production significantly. The results identified PTA-2 as a natural product that could be applied in anti-inflammatory drugs.

show abstract

Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation

Desai,

Tambe,

Pofali

et al. 2024

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, the immune system's inability to discern and eliminate abnormal cells leads to uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, the immune system encounters challenges in clearance and neutralization. Achieving a delicate balance of pro‐inflammatory and anti‐inflammatory signals is essential in managing a range of disorders and diseases. Like in other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among the plethora of nanotechnology‐based interventions, the concept of cell membrane‐coated nanoparticles holds significant potential for immunomodulatory applications owing to their biomimetic properties that allow for precise interaction with the compromised immune system. This review thoroughly examines the potential of novel nanosystems for immune modulation. The exploration covers crucial elements, including the origins and characteristics of cell membranes, the methods employed for their procurement and coating, physicochemical/biological characterization techniques, and enhancement of their therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis of utilizing these bioinspired nanosystems in tackling different conditions caused by immune disturbance has been comprehensively discussed.

show abstract

Inflammation—Dysregulated inflammatory response and strategies for treatment

Cited by 16 publications

References 21 publications

Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium Streptomyces specialis and Their Anti-Inflammatory Activity

Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium Streptomyces specialis and Their Anti-Inflammatory Activity

Isolation, Identification, and Anti-Inflammatory Activity of Polysaccharides of Typha angustifolia

Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation

Contact Info

Product

Resources

About