Inflammation, diet, and type 2 diabetes: a mini-review

Jafaripour, Simin; Sedighi, Sima; Jokar, Mohammad Hassan; Aghaei, Mehrdad; Moradzadeh, Maliheh

doi:10.1080/15321819.2020.1750423

Cited by 11 publications

(12 citation statements)

References 61 publications

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“…Inflammation is a hallmark of various pathological conditions such as those confined locally to the bone, including rheumatoid arthritis [28] and periodontitis [29]. Moreover, systemic inflammation is involved in a myriad of conditions such as kidney disease [30], inflammatory bowel disease [31], chronic skin inflammation [32], bacterial infection [33], cancer [34], acute injury [35], metabolic syndrome in obese patients [36], and diabetes [37]. Proinflammatory cytokines secreted in the bone vicinity enter blood circulation easily and travel to distant organs, causing systemic effects.…”

Section: Osteoclastogenic Cytokinesmentioning

confidence: 99%

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption

Kitaura

Marahleh

Ohori

et al. 2020

IJMS

209

131

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The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte, the mechanosensory cell type. Osteoclasts derived from the hematopoietic stem cell lineage are the principal cells involved in bone resorption. In osteolytic diseases such as rheumatoid arthritis, periodontitis, and osteoporosis, the balance is lost and changes in favor of bone resorption. Therefore, it is vital to elucidate the mechanisms of osteoclast formation and bone resorption. It has been reported that osteocytes express Receptor activator of nuclear factor κΒ ligand (RANKL), an essential factor for osteoclast formation. RANKL secreted by osteocytes is the most important factor for physiologically supported osteoclast formation in the developing skeleton and in pathological bone resorption such as experimental periodontal bone loss. TNF-α directly enhances RANKL expression in osteocytes and promotes osteoclast formation. Moreover, TNF-α enhances sclerostin expression in osteocytes, which also increases osteoclast formation. These findings suggest that osteocyte-related cytokines act directly to enhance osteoclast formation and bone resorption. In this review, we outline the most recent knowledge concerning bone resorption-related cytokines and discuss the osteocyte as the master regulator of bone resorption and effector in osteoclast formation.

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Section: Osteoclastogenic Cytokinesmentioning

confidence: 99%

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption

Kitaura

Marahleh

Ohori

et al. 2020

IJMS

209

131

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“…In some instances, associations have been also revealed with factors such as the composition of the oral microbiota (Jockel-Schneider et al, 2021 ; Li et al, 2021 ). Diet has also been related to inflammation in periodontitis (Woelber et al, 2017 ; Kotsakis et al, 2018 ; Botelho et al, 2021 ; Rowińska et al, 2021 ) and other conditions as disparate as cancer (Deng et al, 2017 ; De Almeida et al, 2019 ), diabetes (Prana et al, 2019 ; Jafaripour et al, 2020 ), cardiovascular diseases (Razquin and Martinez-Gonzalez, 2019 ; Kovell et al, 2020 ), Alzheimer's disease (McGrattan et al, 2019 ), depression (Koopman and El Aidy, 2017 ), and even COVID-19 (Iddir et al, 2020 ).…”

Section: Medical Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

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“…In this regard, the inflammatory potential and insulin resistance related to unhealthy dietary pattern are well-known (9,10). In particular, inflammation (11) and insulin resistance (12,13) have gained growing interest in promoting thyroid cell hyperplasia, thus facilitating the prevalence and malignant growth in thyroid nodular disease.…”

Section: Introductionmentioning

confidence: 99%

Adherence to the Mediterranean Diet as a Modifiable Risk Factor for Thyroid Nodular Disease and Thyroid Cancer: Results From a Pilot Study

Barrea

Muscogiuri

Alteriis³

et al. 2022

Front. Nutr.

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Iodine deficiency is the most important established nutritional risk factor for the development of thyroid nodular disease. Nevertheless, to the best of our knowledge, to date no study focused on the association between the adherence to the Mediterranean diet (MD) and thyroid nodular disease. Adherence to the MD was evaluated using the PREvención con DIetaMEDiterránea (PREDIMED) questionnaire. Physical activity, smoking habits, and anthropometric parameters were studied. PREDIMED was used to evaluate the degree of adherence to the MD. Evaluation of fine needle aspiration cytology of thyroid lesions based on 2013 Italian thyroid cytology classification system. Cytology of thyroid nodules was carried out through sonography-guided fine-needle aspiration and patients were divided into 5 categories: TIR2, TIR3a, TIR3b, TIR4, and TIR5. The study population consisted of 794 subjects (554 females, 69.8%), aged 18–65 years, with BMIs ranging from 19.4 to 55.3 kg/m2. Thyroid nodular disease was present in 391 participants (49.2%), and the most frequent cytological categories was TIR2 (18.3 %), followed by a TIR4 (8.9 %). The presence of thyroid nodules was also significantly associated with the lowest adherence to the MD (OR 6.16, p < 0.001). Patients with TIR5 had the lower adherence to the MD (2.15 ± 1.12 score) compared to other TIRs (p < 0.001). The cytological category with high-risk of malignancy (TIR4/TIR5) was significantly associated with the lowest adherence to the MD (OR 137.55, p < 0.001) and PREDIMED score (OR = 0.33, p < 0.001, 95% IC = 0.26–0.41, R2 = 0.462). At multiple regression analysis, PREDIMED score was the main predictor of both the presence of nodules (p < 0.001) and the cytological category with high-risk of malignancy (p < 0.001). At ROC analysis PREDIMED score ≤ 5 and ≤ 4 (p = 0.001) were the values that predicted the presence of thyroid nodular disease and cytological category with high-risk of malignancy, respectively. In conclusion, our study demonstrated that the low adherence to the MD is associated with the presence of thyroid nodular disease and in particular with those at high-risk of malignancy.

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Inflammation, diet, and type 2 diabetes: a mini-review

Cited by 11 publications

References 61 publications

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption

Periodontal Inflammation and Systemic Diseases: An Overview

Adherence to the Mediterranean Diet as a Modifiable Risk Factor for Thyroid Nodular Disease and Thyroid Cancer: Results From a Pilot Study

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