Inflammation-based prognostic scores to predict outcome in patients with cancer.

McMillan, D.C.; Morrison, David S.; Talwar, Dinesh; Horgan, P.G.; Proctor, Michael

doi:10.1200/jco.2011.29.15_suppl.e21154

Cited by 4 publications

(6 citation statements)

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“…Peripheral blood cell counts typically reflect the inflammatory status of patients, and can serve as useful predictors of prognosis in CRC and other types of cancers [ 7 , 17 ]. In this study, we assessed the value of several inflammatory indices including neutrophil and lymphocyte percentages, platelet count, PDW, white blood cell ratios such as NLR and LMR, as well as a prognostic system that combines NLR and PDW, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…The association between inflammation and cancer has been widely confirmed since it was first proposed by Virchow in 1863 [ 6 ]. Ever since, several inflammation-based prognostic systems have been established, such as the Glasgow Prognostic Score (GPS), the systemic inflammation score (SIS), the neutrophil to lymphocyte ratio (NLR), the lymphocyte to monocyte ratio (LMR), platelet count, among others [ 7 – 11 ], many of which focus on the status of blood cells involved in inflammatory reactions. In clinical studies, decreased LMR [ 9 ], increased platelet count, and increased NLR [ 10 , 12 ] were all related to inferior survival in patients with CRC.…”

Section: Introductionmentioning

confidence: 99%

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Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer

et al. 2017

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Previous studies demonstrated that several inflammation-based hematological indices are closely related to various malignancies, including colorectal cancer (CRC). In this study, the prognostic value of inflammation-based markers, including a combination index termed coNLR-PDW, comprising the preoperative neutrophil-to-lymphocyte ratio (NLR) and the platelet distribution width (PDW), was evaluated in 206 patients with non-metastatic CRC treated with surgery at a single medical center. The association of patient demographics, blood chemistry, and serum biochemical indices with recurrence-free survival (RFS) and overall survival (OS) were examined through univariate and multivariate analysis. Receiver operating characteristic curve analysis revealed the optimal cut-off values of the NLR and lymphocyte-to-monocyte ratio (LMR) to be, respectively, 2.0 and 3.32 for both RFS and OS. For PDW, cut-off values of 17.25% and 17.35% were defined for RFS and OS, respectively. On univariate analysis, lymph node involvement, stage, presence of intravascular emboli (IVE), carbohydrate antigen 199 (CA199) ≥ 35 kU/L, NLR ≥ 2.0, LMR ≤ 3.32, elevated PDW, a high coNLR-PDW score, high blood glucose, and high neutrophil and lymphocyte percentages correlated with poorer RFS and OS (P < 0.05). On multivariate analysis, lymph node involvement, IVE, CA199, PDW, and coNLR-PDW correlated with both RFS and OS (P < 0.05), while NLR correlated only with OS (P = 0.001). These results highlight the usefulness of the coNLR-PDW index as a prognostic marker of non-metastatic CRC outcome. In clinical practice, its assessment could contribute to establishing more personalized regimes for patients undergoing tumor resection surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer

et al. 2017

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“…Previous research has demonstrated that systemic inflammatory responses play a pivotal part in the progression of various malignancies and are closely related to poor prognosis in patients. 9,10 Multiple inflammatory markers that are used to predict the prognosis of patients with malignant tumors can be obtained easily from peripheral blood samples; 11 these predictive indices include the modified Glasgow prognostic score (mGPS), 12 platelet-lymphocyte ratio (PLR), 13 and neutrophil-lymphocyte ratio (NLR). 14 Among these inflammatory markers, the C-reactive protein/albumin (CRP/Alb) ratio has been demonstrated as a prognostic indicator for several cancers, such as hepatocellular carcinoma, 15 esophageal cancer, 16 gastric cancer, 17 lung cancer, 18 newly diagnosed pancreatic cancer, 19 renal cancer, 20 and ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

<p>The CRP/Albumin Ratio Predicts Survival And Monitors Chemotherapeutic Effectiveness In Patients With Advanced Pancreatic Cancer</p>

Fan¹,

Fan²,

Gong³

et al. 2019

CMAR

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The CRP/albumin (Alb) ratio, a recently reported predictor, has shown value for prognosis in various human cancers. This study aimed to determine the prognostic value of baseline CRP/Alb and to explore the relevance between postchemotherapy CRP/Alb and the efficacy of chemotherapy in advanced pancreatic cancer patients. Patients and methods: Five hundred and ninety-five patients diagnosed with locally advanced or metastatic adenocarcinoma of the pancreas were enrolled. Cutoff Finder was used to calculate the best cutoff value for baseline CRP/Alb. The primary endpoint was overall survival, which was analyzed by Kaplan-Meier survival curves with 95% confidence intervals. The log rank test and Cox proportional hazard model were used to evaluate the univariate and multivariate analyses. Results: The optimal cutoff value for baseline CRP/Alb was determined to be 0.18. Both the baseline CRP/Alb (CRP/Alb≥0.18 vs. CRP/Alb<0.18, hazard ratio [HR] = 2.506; p<0.001) and postchemotherapy CRP/Alb (CRP/Alb≥0.18 vs. CRP/Alb<0.18, HR = 1.854; p =0.002) were significant predictors of overall survival according to multivariate analysis and were independent of other factors. Patients with a baseline and postchemotherapy CRP/ Alb ≥0.18 had the worst prognosis. Conclusion: CRP/Alb is a strong and useful indicator of prognosis for advanced pancreatic cancer. Both baseline and postchemotherapy CRP/Alb can be used in predicting the survival of patients and monitoring the effectiveness of chemotherapy in clinical practice.

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“…Platelet/lymphocyte ratio is the other increased marker in inflammatory diseases and is considered to have prognostic importance. 8 When the studies examining its relationship with AD are examined, Jiang et al 9 found a correlation with disease severity. However, there was no difference between control and study groups in terms of PLR values.…”

Section: Discussionmentioning

confidence: 99%

“…7 Atopic dermatitis, which is dominated by chronic inflammation, is one of these diseases. 5,8,9 However, these parameters may also be affected by many factors, such as tinnitus, psychiatric disorders, some types of headaches, and smoking, which are widespread conditions in the population. [10][11][12] Therefore, this significant fact raises questions for the clinical use of the parameters.…”

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confidence: 99%

Assessment of Venous Blood Leukocyte Profiles and Immunoglobulin E Levels in Atopic Dermatitis Patients

Kara

Solak

2022

Dermatitis

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BackgroundThere are differing results in the literature regarding the relationship between atopic dermatitis (AD) and peripheral blood leukocyte profiles.ObjectiveThe aim of the study was to investigate the relationship between AD, blood immune cell profiles, and disease severity.MethodsOne hundred AD patients aged 1 month to 18 years without any history of infection or systemic disease were enrolled as the study group. Serum concentration levels of total immunoglobulin E, calculated blood leukocyte profiles, and AD index severity scoring were calculated for statistical comparison.ResultsThe differences between the groups for neutrophil-lymphocyte ratio and eosinophil-lymphocyte ratio were statistically different. However, there was no statistically significant correlation between the investigated parameters and AD index severity scoring.ConclusionsAlthough significant differences were found in some of the parameters between the groups, unfortunately, the lack of correlation between the parameters investigated and the disease severity index restricts their use in clinical practice.

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Inflammation-based prognostic scores to predict outcome in patients with cancer.

Cited by 4 publications

References 0 publications

Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer

Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer

<p>The CRP/Albumin Ratio Predicts Survival And Monitors Chemotherapeutic Effectiveness In Patients With Advanced Pancreatic Cancer</p>

Assessment of Venous Blood Leukocyte Profiles and Immunoglobulin E Levels in Atopic Dermatitis Patients

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