Inflammation and quality of life in later life: findings from the health, well-being and aging study (SABE)

Roediger, Manuela de Almeida; Marucci, Maria de Fátima Nunes; Duim, Etienne; Santos, Jair Lício Ferreira; Duarte, Yeda Aparecida de Oliveira; Oliveira, César de

doi:10.1186/s12955-019-1092-2

Cited by 28 publications

(24 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results might raise the possibility that inflammation in PTSD is involved more in psychological rather than physical aspects of QOL. However, our findings are not in agreement with previous studies that reported significant relationships between inflammation and physical QOL 32,38,42 . This inconsistency may be ascribed to differential measures for assessing QOL between studies, given that the present study used WHOQOL-BREF whereas the previous studies used the 36-item (or 12-item) Short-Form Health Survey (SF-36/SF-12) 32,38,42 .…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Relationships of blood proinflammatory markers with psychological resilience and quality of life in civilian women with posttraumatic stress disorder

Imai

Hori

Itoh

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Individuals with posttraumatic stress disorder (PTSD) show low resilience and impaired quality of life (QOL). Accumulating evidence shows that PTSD is associated with increased inflammation. Studies suggest that inflammation can be a key mechanism underlying low resilience/QOL, but this relationship has been understudied in individuals with PTSD. Here, we investigated the association of blood proinflammatory markers with self-reported resilience and QOL in civilian women with PTSD. Fifty-six women with PTSD and 73 healthy control women participated in this study. Resilience was assessed using the Connor-Davidson Resilience Scale. QOL was assessed using the World Health Organization Quality of Life-BREF. Blood samples were collected for the measurement of three proinflammatory markers including interleukin-6 (IL-6), high-sensitivity tumor necrosis factor-α, and high-sensitivity C-reactive protein (hsCRP). Compared to controls, patients showed significantly higher IL-6 levels and lower resilience and QOL. In patients, IL-6 levels were significantly negatively correlated with resilience, and hsCRP levels were significantly negatively correlated with psychological QOL. These results show that increased levels of proinflammatory markers including IL-6 and hsCRP are associated with lower psychological resilience and QOL in PTSD patients. Our findings suggest that interventions and treatments targeting inflammation may aid in the recovery from PTSD and lead to better prognosis.

show abstract

Section: Discussioncontrasting

confidence: 99%

“…Various lines of research have demonstrated that elevated inflammation is associated with low psychological resilience 30,31 and QOL 32,33 . Indeed, alterations in the immune/inflammatory system is considered one of the most important biological factors contributing to resilience 30,31 .…”

Section: Introductionmentioning

confidence: 99%

Relationships of blood proinflammatory markers with psychological resilience and quality of life in civilian women with posttraumatic stress disorder

Imai

Hori

Itoh

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“… 37 Finally, the increased levels of C reactive protein and interleukin-6 due to poor sleep quality have been found to be associated with poor HRQoL. 38 …”

Section: Discussionmentioning

confidence: 99%

Association between night-shift work, sleep quality and health-related quality of life: a cross-sectional study among manufacturing workers in a middle-income setting

Lim

Hoe

Darus³

et al. 2020

BMJ Open

View full text Add to dashboard Cite

ObjectivesNight-shift work may adversely affect health. This study aimed to determine the impact of night-shift work on health-related quality of life (HRQoL), and to assess whether sleep quality was a mediating factor.DesignA cross-sectional study.Setting11 manufacturing factories in Malaysia.Participants177 night-shift workers aged 40–65 years old were compared with 317 non-night-shift workers.Primary and secondary outcomesParticipants completed a self-administered questionnaire on socio-demographics and lifestyle factors, 12-item Short Form Health Survey V.2 (SF-12v2) and the Pittsburgh Sleep Quality Index (PSQI). The Baron and Kenny’s method, Sobel test and multiple mediation model with bootstrapping were applied to determine whether PSQI score or its components mediated the association between night-shift work and HRQoL.ResultsNight-shift work was associated with sleep impairment and HRQoL. Night-shift workers had significantly lower mean scores in all the eight SF-12 domains (p<0.001). Compared with non-night-shift workers, night-shift workers were significantly more likely to report poorer sleep quality, longer sleep latency, shorter sleep duration, sleep disturbances and daytime dysfunction (p<0.001). Mediation analyses showed that PSQI global score mediated the association between night-shift work and HRQoL. ‘Subjective sleep quality’ (indirect effect=−0.24, SE=0.14 and bias corrected (BC) 95% CI −0.58 to −0.01) and ‘sleep disturbances’ (indirect effect=−0.79, SE=0.22 and BC 95% CI −1.30 to −0.42) were mediators for the association between night-shift work and physical well-being, whereas ‘sleep latency’ (indirect effect=−0.51, SE=0.21 and BC 95% CI −1.02 to −0.16) and ‘daytime dysfunction’ (indirect effect=−1.11, SE=0.32 and BC 95% CI −1.86 to −0.58) were mediators with respect to mental well-being.ConclusionSleep quality partially explains the association between night-shift work and poorer HRQoL. Organisations should treat the sleep quality of night-shift workers as a top priority area for action to improve their employees’ overall wellbeing.

show abstract

“…This might be due to their ability to maintain the balance of the intestinal microbiota, regulate the immunomodulatory responses as well as suppression of the potential pathogens, and the inhibition of carcinogenesis [ 12 , 16 , 17 ]. Since elevated inflammation and oxidative stress are associated with impairment of quality of life [ [20] , [21] , [22] , [23] , [24] ], thus, using synbiotics might be promising in improving the quality of life in patients with BCRL.…”

Section: Introductionmentioning

confidence: 99%

Calorie restriction and synbiotics effect on quality of life and edema reduction in breast cancer-related lymphedema, a clinical trial

et al. 2020

View full text Add to dashboard Cite

Background Little evidence exists regarding the clinical value of synbiotics in the management of post-treatment complications of breast cancer especially breast cancer-related lymphedema (BCRL). This study aimed to investigate the effects of synbiotic supplementation along with calorie restriction on quality of life and edema volume in patients with BCRL. Methods This randomized, placebo-controlled, clinical trial was conducted on 135 overweight and obese women with BCRL aged 18–65 years old. Participants were randomly allocated to receive a calorie-restricted diet plus 10 9 CFU synbiotic supplement (CRS group; n = 45) or placebo (CRP group; n = 45), daily for 10 weeks. Also, a control group (n = 45) with no intervention was included in the trial. All of the participants received Complete Decongestive Therapy for lymphedema treatment. The quality of life score, edema volume and body mass index (BMI) were measured at baseline and end of the trial. Results A total of 121 subjects completed the trial. CRS group showed a significant decrease in the total quality of life score (P = 0.004), and it’s psychosocial ( P = 0.022) and functional ( P = 0.002) domain scores, as well as edema volume ( P = 0.002) and BMI ( P < 0.001) in comparison to the control. However, there were no significant differences in changes in trial outcomes between the CRS and CRP groups. Conclusion Synbiotic supplementation along with a low-calorie diet was effective in quality of life, edema volume, and BMI improvement; mostly due to low-calorie diet. It seems that adding a dietitian consultation on the lymphedema management strategy may provide a better result in lymphedema control.

show abstract

Inflammation and quality of life in later life: findings from the health, well-being and aging study (SABE)

Cited by 28 publications

References 41 publications

Relationships of blood proinflammatory markers with psychological resilience and quality of life in civilian women with posttraumatic stress disorder

Relationships of blood proinflammatory markers with psychological resilience and quality of life in civilian women with posttraumatic stress disorder

Association between night-shift work, sleep quality and health-related quality of life: a cross-sectional study among manufacturing workers in a middle-income setting

Calorie restriction and synbiotics effect on quality of life and edema reduction in breast cancer-related lymphedema, a clinical trial

Contact Info

Product

Resources

About