Inflammation and Psoriasis: A Comprehensive Review

Man, Alessandra-Mădălina; Orăsan, Meda Sandra; Hoteiuc, Oana-Alina; Olănescu-Vaida-Voevod, Maria-Cristina; Mocan, Teodora

doi:10.3390/ijms242216095

Cited by 12 publications

(7 citation statements)

References 212 publications

(207 reference statements)

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“…Established studies have shown that chronic inflammation of the skin is not only a local problem. It induces inflammation in organs throughout the body, causing cardiovascular and cerebrovascular disorders, systemic amyloidosis, and other organ damage [ 20 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. Furthermore, it is known to induce inflammation in adipose tissue, with known effects such as weight loss due to adipose tissue atrophy, decreased heat production capacity, and increased production of inflammatory adipocytokines [ 23 , 36 , 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Increased Mortality Risk at Septic Condition in Inflammatory Skin Disorders and the Effect of High-Fat Diet Consumption

Nishimura,

Nakanishi,

Ichishi

et al. 2023

IJMS

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In recent years, attention has increasingly focused on various infectious diseases. Although some fatalities are directly attributed to the causative virus, many result from complications and reactive inflammation. Patients with comorbidities are at a higher risk of mortality. Refractory skin conditions such as atopic dermatitis, psoriasis, and epidermolysis bullosa, known for an elevated risk of sepsis, partly owe this to compromised surface barrier function. However, the detailed mechanisms underlying this phenomenon remain elusive. Conversely, although the detrimental effects of a high-fat diet on health, including the onset of metabolic syndrome, are widely recognized, the association between diet and susceptibility to sepsis has not been extensively explored. In this study, we examined the potential causes and pathogenesis of increased sepsis susceptibility in inflammatory skin diseases using a mouse dermatitis model: keratin 14-driven caspase-1 is overexpressed (KCASP1Tg) in mice on a high-fat diet. Our findings reveal that heightened mortality in the dermatitis mouse model is caused by the inflamed immune system due to the chronic inflammatory state of the local skin, and administration of LPS causes a rapid increase in inflammatory cytokine levels in the spleen. Intake of a high-fat diet exacerbates these cytokine levels. Interestingly, we also observed a reduced expression of Toll-like receptor 4 (TLR4) in monocytes from KCASP1Tg mice, potentially predisposing these animals to heightened infection risks and associated complications. Histological analysis showed a clear decrease in T and B cells in the spleen of KCASP1Tg mice fed a high-fat diet. Thickening of the alveolar wall, inflammatory cell infiltration, and alveolar hemorrhage were more prominent in the lungs of KCASP1Tg and KCASP1Tg with fat mice. We postulate that the chronic, non-infectious inflammation induces a negative feedback loop within the inflammatory cascade, and the suppressed expression of TLR4 renders the mice more susceptible to infections. Therefore, it is imperative for individuals with chronic skin inflammation to closely monitor disease progression upon infection and seek timely and appropriate treatment. Additionally, chronic inflammation of adipose tissue, induced by high-fat food intake, combined with dermatitis inflammation, may exacerbate infections, necessitating a review of dietary habits.

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Section: Discussionmentioning

confidence: 99%

Increased Mortality Risk at Septic Condition in Inflammatory Skin Disorders and the Effect of High-Fat Diet Consumption

Nishimura,

Nakanishi,

Ichishi

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…The relationship between psoriasis and obesity has been a subject of increasing interest within the medical research community [4][5][6] , given the growing evidence suggesting that obesity, as a prevalent and potentially modi able risk factor, can exacerbate the clinical trajectory of psoriasis and vice versa 4,6,7 . It was found that the in ammatory pathways shared between obesity and psoriasis, which involve cytokines such as TNF-α and IL-6, may suggest a biological plausibility for their bidirectional correlations [8][9][10] . Both conditions are associated with a heightened risk of mortality 3,11 .…”

Section: Introductionmentioning

confidence: 99%

Associations Between Body Mass Index and All-Cause Mortality Among Individuals with Psoriasis: Results from the NHANES database retrospective cohort study

Wei,

Nie,

Sadik

et al. 2024

Preprint

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Background Previous findings imply a potential positive association between BMI and all-cause mortality in individuals with psoriasis, yet direct evidence remains absent. This study aimed to fill this gap. Methods We utilized data from the National Health and Nutrition Examination Survey (NHANES) for the periods 2003–2006 and 2009–2014. Participants' BMI was categorized as lean (< 25), overweight (25 ≤ BMI < 30), and obese (BMI ≥ 30). Psoriasis status was determined through self-reporting. The main outcome measured was all-cause mortality up to December 2019. We accounted for multiple covariates, such as sociodemographic factors and histories of smoking and alcohol consumption. Our statistical analyses mainly included Kaplan-Meier survival analysis, Restricted Cubic Spline (RCS) and Multivariate Cox Regression (MCR). We also applied propensity score matching (PSM) to verify the robustness of our findings. Results Among 22,876 participants, 618 (2.70%) reported a history of psoriasis. An overall effect from the MCR analysis showed that, among individuals with psoriasis, a higher baseline BMI was independently associated with an increased risk of all-cause mortality, noting a 5.5% rise in mortality risk per BMI unit [hazard ratio (HR) = 1.055, 95% CI: 1.004–1.110, p = 0.035]. This significant relationship persisted after PSM. A statistically significant positive correlation was consistent among males, smokers, and individuals younger than 60. However, no such association was found in individuals without a history of psoriasis. Additionally, no significant difference in mortality risk was found between lean and overweight groups with psoriasis, according to the RCS regression and stratified analysis. Conclusions Our findings indicated a trend that, higher BMIs significantly correlated with increased risks of all-cause mortality in people with psoriasis, particularly among obese ones. However, the impact of being overweight on this relationship remains underexplored. Moreover, the necessity to employ alternative metrics beyond BMI for body fat assessment to further investigate these associations is critical.

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“…Affected skin may be degenerated to silver, white, or red with scaly plaques [2]. Itching, scaling, burning, erythema, and bleeding are the most routine psoriasis symptoms [3]. About 3 % of the world's population (around 125 million persons) is affected by psoriasis, with up to 30 % frequency of complicated cases [4].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the anti-psoriasis effect of Scrophularia deserti methanolic extract in mice model

Khaleel,

Shareef,

Maryoosh

2024

SR: PS

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Psoriasis is an underestimated chronic and autoimmune skin disorder. Topical chemical agents are applied for psoriasis control and treatment, notwithstanding their subordinate efficiency or unsuccessful activities. As an alternative, herbal medicine can also be used in its treatment. The aim of the present study was performed to assess the anti-psoriasis effect of Scrophularia deserti in mice model. Materials and methods: S. deserti was purchased and used for methanolic extraction. Extract DPPH radical scavenging activity, polyphenol and flavonoid contents were examined. Sixty male mice were purchased, and psoriasis was induced using 10 days of topical administration of Imiquimod (62.5 mg). Mice were classified into 6 groups: non-psoriasis control (only received distilled water), psoriasis control (only received topical Imiquimod), two S. deserti treatments (topical 300 and 500 mg/kg), topical Betamethasone, and topical α-pinene 9 %. Cytokine distribution and histopathological properties were also determined. Results: the value at which the S. deserti methanolic extract scavenges 50 % of free radicals (IC50) was 602.71±15.33 µg/mL. The total S. deserti methanolic extract flavonoid and polyphenol contents were 16.85±1.12 mg QE/g and 58.47±3.25 mg GAE/g, respectively. IL-22, TNF-α, and IL-17A concentrations increased after psoriasis induction compared to the control group (P <0.05). Mice treated with Betamethasone harboured the lowest concentrations of IL-22, TNF-α, and IL-17A (P <0.05). Conclusions: Mice treated with S. deserti methanolic extract (500 mg/kg) also harboured significantly lower IL-22, TNF-α, and IL-17A (P <0.05) compared to α-pinene and S. deserti methanolic extract (300 mg/kg). Mice of the psoriasis control group showed significant epidermis hyperkeratosis, acanthosis, and crust with plentiful inflammatory cells. At the same time, mice treated with S. deserti methanolic extract (500 mg/kg) showed significant recovered tissue with normal skin epidermis and dermis, sebaceous glands, and follicles of the hair, besides the lowest rate of inflammatory reactions. Findings showed that the S. deserti methanolic extract (500 mg/kg) can efficiently be used as a practical substitute for psoriasis treatment. However, some supplementary research should be performed

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Inflammation and Psoriasis: A Comprehensive Review

Cited by 12 publications

References 212 publications

Increased Mortality Risk at Septic Condition in Inflammatory Skin Disorders and the Effect of High-Fat Diet Consumption

Increased Mortality Risk at Septic Condition in Inflammatory Skin Disorders and the Effect of High-Fat Diet Consumption

Associations Between Body Mass Index and All-Cause Mortality Among Individuals with Psoriasis: Results from the NHANES database retrospective cohort study

Assessment of the anti-psoriasis effect of Scrophularia deserti methanolic extract in mice model

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