Inflammation and peripheral 5-HT7 receptors: The role of 5-HT7 receptors in carrageenan induced inflammation in rats

Albayrak, Abdulmecit; Halıcı, Zekai; Çadırcı, Elif; Polat, Beyzagül; Karakuş, Emre; Bayır, Yasin; Ünal, Deniz; Atasoy, Mustafa; Doğrul, Ahmet

doi:10.1016/j.ejphar.2013.05.010

Cited by 42 publications

(27 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total RNA Extraction and cDNA Synthesis M a n u s c r i p t 17 A total RNA extraction and a cDNA synthesis were performed according to our previous data (Albayrak et al, 2013a). Tissues (20 mg) were briefly stabilized in an RNA Stabilization Reagent (RNAlater, Qiagen) and then disrupted using the TissueLyser II (2 x 2 minutes for kidney; 2 x 5 minutes, Qiagen).…”

Section: Molecular Investigations Of Kidney Tissuesmentioning

confidence: 99%

Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy

Sarıtemur

Çadırcı

et al. 2015

Environmental Toxicology and Pharmacology

Self Cite

View full text Add to dashboard Cite

Section: Molecular Investigations Of Kidney Tissuesmentioning

confidence: 99%

Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy

Sarıtemur

Çadırcı

et al. 2015

Environmental Toxicology and Pharmacology

Self Cite

View full text Add to dashboard Cite

“…Total RNA extraction and cDNA synthesis Total RNA extraction and cDNA synthesis were performed as described earlier [22]. Briefly, the tissues (20 mg) were stabilized in an RNA stabilization reagent (RNAlater, Qiagen) and then disrupted using a Tis-sueLyser II (2 × 2 min for lung; 2 × 5 min, Qiagen).…”

Section: Molecular Investigationsmentioning

confidence: 99%

Investigation of the effect of telmisartan on experimentally induced peripheral nerve injury in rats

Yüksel¹,

Halıcı²,

Demir³

et al. 2014

International Journal of Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is well known that carrageenan-induced paw oedema model result in oxidative stress with the increase lipid peroxidation or the depletion of antioxidant sulfhydryl pool such as glutathione, during the acute phase of inflammation in cells (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress

et al. 2018

View full text Add to dashboard Cite

The present study aimed to investigate the role of cannabinoid 2 (CB2) receptors in a rat model of acute inflammation. Therefore, the potential of anti-inflammatory effects of CB2 receptor agonist (GW405833), CB2 receptor antagonist (AM630), and diclofenac, were investigated in carrageenan induced paw oedema in rats: as were assessed by measuring paw oedema; myeloperoxidase (MPO) activity in paw tissue; malondialdehyde (MDA) concentration; glutathione (GSH) level in paw tissue for oxidant/antioxidant balance; cytokine (interleukin-1β, IL-1β; tumour necrosis factor-α, TNF-α) levels in serum; histopathology of paw tissue for inflammatory cell accumulations. The results showed that GW405833 or diclofenac significantly reduced carrageenan-induced paw oedema. GW405833 also inhibited the increase of MPO activity, the recruitment of total leukocytes and neutrophils, and MDA concentration during carrageenan-induced acute inflammation, along with reversed nearly to the normal levels the increased of TNF-α, and IL-1β in serum. AM630 did not affect inflammation alone however clearly reversed the effects of agonist when co-administered. The mechanism of GW405833's suppression of inflammation is supported by these results, which are achieved by the inhibition of neutrophil migration, which regulates the reduction of oxidative stress, TNF-α and IL-1β levels. Finally, the activation of CB2 receptor, by selective agonist, has a major role in peripheral inflammation, and in the near future, targeting the peripheral cannabinoid system as a promising alternative to treat inflammation diseases may be considered a novel pharmacologic approach.

show abstract

Inflammation and peripheral 5-HT7 receptors: The role of 5-HT7 receptors in carrageenan induced inflammation in rats

Cited by 42 publications

References 74 publications

Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy

Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy

Investigation of the effect of telmisartan on experimentally induced peripheral nerve injury in rats

The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress

Contact Info

Product

Resources

About