Inflammation and pancreatic cancer: An updated review

Shadhu, Kamleshsingh; Xi, Chunhua

doi:10.4103/sjg.sjg_390_18

Cited by 64 publications

(63 citation statements)

References 188 publications

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“…Furthermore, CCR3, CCR4, CCR5 and CCR8 were also found to be associated with viral carcinogenesis, a greater number of CCR genes than those identified to be concerned with carcinogenesis in previous studies (23,65–68). Since various studies have shown its close association with inflammation and immunity (69–75), this is highly relevant to PDAC. Also, considering the function of CCR genes in mediating inflammation, and that CCR5, CCR6 and CCR9 were significantly associated with the overall survival of patients with early-stage PDAC (as indicated by the results of survival analysis), it was concluded that CCR5, CCR6 and CCR9 serve important roles in the development and progression of PDAC.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

et al. 2019

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The present study aimed to determine the clinical significance and potential molecular mechanisms of CC motif chemokine receptor (CCR) genes in patients with early-stage pancreatic ductal adenocarcinoma (PDAC). The transcriptomic, survival and clinical data of 112 patients with early-stage PDAC who underwent pancreaticoduodenectomy were obtained from The Cancer Genome Atlas. The prognostic values of the CCR genes involved in early-stage PDAC were evaluated using Kaplan-Meier analysis and the multivariate Cox proportional risk regression model, and the potential molecular mechanisms were determined using bioinformatics tools. The identified CCRs closely interacted with each other at both the gene and protein levels. High expression levels of CCR5 [adjusted P=0.012; adjusted hazard ration (HR)=0.478, 95% confidence interval (CI)= 0.269-0.852], CCR6 (adjusted P= 0.026; adjusted HR= 0.527, 95% CI= 0.299-0.927) and CCR9 (adjusted P=0.001; adjusted HR=0.374, 95% CI= 0.209-0.670) were significantly associated with longer overall survival times in patients with early-stage PDAC. The contribution of CCR5, CCR6 and CCR9 to the outcome of early-stage PDAC was also demonstrated. Combined survival analysis of CCR5, CCR6 and CCR9 suggested that patients with high expression levels of these CCRs exhibited the most favorable outcomes. A prognostic signature was constructed in terms of the expression level of CC5, CCR6 and CCR9, and time-dependent receiver operating characteristic curves indicated that this signature was able to effectively predict the outcome of patients with early-stage PDAC. The potential molecular mechanisms of CCR5, CC6 and CCR9 in PDAC include its intersection of the P53, nuclear factor (NF)-κB, generic transcription, mitogen-activated protein kinase and STAT signaling pathways. Collectively, this highlights that CCR5, CCR6 and CCR9 are potential prognostic biomarkers for early-stage PDAC.

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Section: Discussionmentioning

confidence: 99%

Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

et al. 2019

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“…[ 17 ] TNF-a is known to induce activation of NF-κB , a transcription factor, to convert tumor suppressors to tumor promotors and substances such as IL-6 to induce pancreatic intraepithelial neoplasia. [ 18 ] In a previous nationwide population-based cohort study of the association between candidiasis and cancer, there was a significant association between candidiasis groups and pancreatic cancer. The association in this study was attributed as surveillance bias, but the association has been reported in various studies.…”

Section: Discussionmentioning

confidence: 99%

Risk of cancer in patients with recurrent aphthous stomatitis in Korea

et al. 2021

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The relationship between recurrent aphthous stomatitis (RAS), a common mucosal lesion, and cancer has not been demonstrated. This study investigated the risk for developing cancer in patients with RAS, based on data from Korea's National Health Insurance Sharing Service (NHISS). Nationwide population-based cohort data from 2005 to 2009 provided by the NHISS was used. The group diagnosed with RAS for 5 years and an undiagnosed control group were constructed through 1:1 propensity score matching (PSM). The experimental design compared the incidence rate of a cancer diagnosis from 2010 to 2015 between these 2 groups. After identifying 13,808 people that met our inclusion criterion from a 1 million cohort group, 13,808 controls were included in the study through PSM. Among all cancers, pancreatic cancer had an adjusted hazard ratio of 1.26 (95% confidence interval: 1.01–1.57, P < .041). For the rest of the cancers, there was no significant incidence rate. RAS was associated with an increased risk of pancreatic cancer in the analysis using large population-based cohort data. Further long-term follow-up studies are needed.

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“…We are aware of that our proteomic analysis is a snapshot of established PDAC cases, and the propose bacteria-induced carcinogenesis model for the biliary tract is still speculative, not validated, and therefore must be interpreted with caution ( Figure 3 ). The model initiates with unique or multiple dysbiotic factors that promote repeated inflammatory events ( 80 ), classically described as stones in the biliary tract, tobacco use, obesity, diabetes mellitus or genetic factors ( 81 ). Those promoting factors change the usual biliary tract bacteria composition expected for that individual, shaped according to diet, genetic background, sex, race, age, etc.…”

Section: Discussionmentioning

confidence: 99%

Biliary Tract Carcinogenesis Model Based on Bile Metaproteomics

et al. 2020

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Purpose: To analyze human and bacteria proteomic profiles in bile, exposed to a tumor vs. non-tumor microenvironment, in order to identify differences between these conditions, which may contribute to a better understanding of pancreatic carcinogenesis. Patients and Methods: Using liquid chromatography and mass spectrometry, human and bacterial proteomic profiles of a total of 20 bile samples (7 from gallstone (GS) patients, and 13 from pancreatic head ductal adenocarcinoma (PDAC) patients) that were collected during surgery and taken directly from the gallbladder, were compared. g:Profiler and KEGG (Kyoto Encyclopedia of Genes and Genomes) Mapper Reconstruct Pathway were used as the main comparative platform focusing on over-represented biological pathways among human proteins and interaction pathways among bacterial proteins. Results: Three bacterial infection pathways were over-represented in the human PDAC group of proteins. IL-8 is the only human protein that coincides in the three pathways and this protein is only present in the PDAC group. Quantitative and qualitative differences in bacterial proteins suggest a dysbiotic microenvironment in the PDAC group, supported by significant participation of antibiotic biosynthesis enzymes. Prokaryotes interaction signaling pathways highlight the presence of zeatin in the GS group and surfactin in the PDAC group, the former in the metabolism of terpenoids and polyketides, and the latter in both metabolisms of terpenoids, polyketides and quorum sensing. Based on our findings, we propose a bacterial-induced carcinogenesis model for the biliary tract. Conclusion: To the best of our knowledge this is the first study with the aim of comparing human and bacterial bile proteins in a tumor vs. non-tumor microenvironment. We proposed a new carcinogenesis model for the biliary tract based on bile metaproteomic findings. Our results suggest that bacteria may be key players in biliary tract carcinogenesis, in a long-lasting dysbiotic and epithelially harmful microenvironment, in which specific bacterial species' biofilm formation is of utmost importance. Our finding should be further explored in future using in vitro and in vivo investigations.

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Inflammation and pancreatic cancer: An updated review

Cited by 64 publications

References 188 publications

Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

Risk of cancer in patients with recurrent aphthous stomatitis in Korea

Biliary Tract Carcinogenesis Model Based on Bile Metaproteomics

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