Inflammation and Oxidative Stress in Patients on Hemodiafiltration

Filiopoulos, Vasilis; Hadjiyannakos, Dimitrios; Metaxaki, Polixeni; Sideris, Vasilis; Takouli, Lambrini; Anogiati, Angeliki; Vlassopoulos, Dimosthenis

doi:10.1159/000142724

Cited by 50 publications

(38 citation statements)

References 77 publications

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“…The expression of the inducible subunit of nitric oxide synthase remained unchanged. This positive effect on oxidative stress and inflammation has also been observed by others [27]. Regarding the effect of HDF on the nutritional status, the results thus far are rather mixed.…”

Section: Effects Of Hdf On Uremic Inflammationsupporting

confidence: 69%

Effects of Hemodiafiltration on Uremic Inflammation

2013

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Chronic inflammation is highly prevalent among end-stage renal disease patients and is linked to, and thought to contribute to, the high morbidity and mortality in this patient population. Hemodiafiltration (HDF) may potentially reduce inflammatory stimuli induced by the bioincompatibility of conventional hemodialysis (HD) systems. In addition, HDF may more efficiently remove inflammatory mediators. This brief review shows that the circulating levels of various markers of systemic inflammation in general are somewhat reduced in patients treated by HDF as compared to HD. On the other hand, according to the current literature, this favorable small impact on inflammation biomarkers does not seem to translate into better clinical outcomes. It is possible that this is due to inadequate design, inadequate number of investigated patients and too short duration of previous studies. The results of larger, better-designed ongoing prospective studies may hopefully clarify this.

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Section: Effects Of Hdf On Uremic Inflammationsupporting

confidence: 69%

Effects of Hemodiafiltration on Uremic Inflammation

2013

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“…Several reports have shown a positive correlation between serum ROM and hsCRP levels in patients with coronary artery disease 28) and those undergoing hemodialysis 29,30) . To our knowledge, however, there has been only one report 31) on the general population.…”

Section: Discussionmentioning

confidence: 96%

Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Hara

Kawabe

Komiya

et al. 2009

JAT

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Aim: Both oxidative stress and inflammation are known to play roles in the pathogenesis of cardiovascular disease. We investigated the relations between reactive oxygen metabolites (ROMs) and various inflammatory and metabolic parameters in a Japanese population. Methods: We analyzed 48 male and 69 female subjects, aged 25 to 65 years, who underwent an annual health checkup in our university. Serum ROM level was assayed using a free radical elective evaluator. We also measured serum concentrations of high-sensitivity C-reactive protein (hsCRP), insulin, and high molecular weight (HMW) adiponectin. Results: Although the serum ROM level in females (347 83 Carr U) was slightly higher than in males (333 53 Carr U), this was not statistically significant. In the 48 male subjects, the ROM level

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“…An observational study of the Dialysis Outcome and Practice Patterns Study (DOPPS) demonstrated the possible benefit of on-line HDF in patient survival independently of the higher dialysis dose compared to HD [22]. Although the mechanisms are not clear, a larger spectrum of removed uremic toxins by convection might be beneficial to decreased oxidative stress, inflammation, and possibly improve long-term outcome [23]. Evidence now supports the hypothesis that middle or large molecular uremic toxins that are not efficiently removed by conventional low-flux HD might contribute to chronic inflammation and subsequent morbidity and mortality in HD patients.…”

Section: Discussionmentioning

confidence: 99%

Microinflammation in Hemodialysis Patients Is Associated with Increased CD14<sup>+</sup>CD16<sup>+</sup> Pro-Inflammatory Monocytes: Possible Modification by On-Line Hemodiafiltration

et al. 2011

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Background: An increased percentage of pro-inflammatory CD14⁺CD16⁺ monocytes might contribute to inflammation in hemodialysis (HD) patients. The purpose of the study was to evaluate the possible contribution of pro-inflammatory monocytes to inflammation in HD patients and also to evaluate the effect of on-line hemodiafiltration (HDF). Methods: Flow cytometric detection of monocytes in patients undergoing HD, on-line HDF and healthy controls as well as plasma cytokines and cytokine mRNA measurement were performed. Results: Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly increased in HD patients. Intracellular cytokine staining showed pro-inflammatory monocytes were the predominant source of tumor necrosis factor-α. Percent pro-inflammatory monocytes positively correlated with plasma inflammatory cytokines. Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly decreased in on-line HDF patients. Conclusion: Increased pro-inflammatory monocytes are likely to contribute to inflammation in HD patients, and beneficial effect of on-line HDF might be partially mediated by modulating the inflammatory response.

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Inflammation and Oxidative Stress in Patients on Hemodiafiltration

Cited by 50 publications

References 77 publications

Effects of Hemodiafiltration on Uremic Inflammation

Effects of Hemodiafiltration on Uremic Inflammation

Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Microinflammation in Hemodialysis Patients Is Associated with Increased CD14<sup>+</sup>CD16<sup>+</sup> Pro-Inflammatory Monocytes: Possible Modification by On-Line Hemodiafiltration

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