Inflammation and Neuroprotection in Traumatic Brain Injury

Corps, Kara N.; Roth, Theodore L.; McGavern, Dorian B.

doi:10.1001/jamaneurol.2014.3558

Cited by 654 publications

(575 citation statements)

References 66 publications

(95 reference statements)

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“…HMGB1 has a pivotal role in the induction of neuroinflammatory processes in neurodegenerative conditions (Fang et al, 2012), cerebral ischemia (Yang et al, 2010), traumatic brain injury (Corps et al, 2015), seizure (Vezzani, 2014), and ethanolinduced neurotoxicity (Zou and Crews, 2014). HMGB1 is a DNA structural protein that has been co-opted by the innate immune system to signal damage during sterile inflammatory conditions (Bianchi, 2007).…”

Section: Hmgb1mentioning

confidence: 99%

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner

Frank

Maier

2016

Neuropsychopharmacol

174

125

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Major depressive disorder (MDD) and other mood disorders remain difficult to effectively treat, and innovative interventions and therapeutic targets are needed. Psychological stressors and inappropriate inflammation increase the risk and severity of mood disorders; however, only recently have the importance of sterile inflammatory processes in this effect been revealed. This review will introduce the reader to pathogen vs sterile inflammation, inflammatory receptor-ligand interactions, microbialassociated molecular patterns (MAMPs), pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and the more recent discovery of the role of the inflammasome in peripheral and central nervous system cytokine/chemokine inflammatory responses. The review will focus on current preclinical and clinical evidence that sterile inflammation and inflammasome-dependent signaling may contribute to mood disorders. By understanding these inflammatory signaling processes, new approaches for quieting chronic or inappropriate inflammatory states may be revealed and this could serve as novel pharmacological targets for the treatment of mood disorders.

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Section: Hmgb1mentioning

confidence: 99%

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner

Frank

Maier

2016

Neuropsychopharmacol

174

125

View full text Add to dashboard Cite

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“…Traumatic brain injury (TBI) is another important focal form of acquired brain injury that occurs when a sudden trauma damages the brain. It is usually caused either by closed or by open, penetrating head injury, and is often the result of car accidents, firearms or falls [6]. Since its pathophysiology shares many of its mechanisms with stroke, we will address these 2 pathologies together.…”

Section: Cannabinoids and Acute Brain Damage: Stroke And Brain Traumamentioning

confidence: 99%

Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications

2015

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Cannabinoids form a singular family of plantderived compounds (phytocannabinoids), endogenous signaling lipids (endocannabinoids), and synthetic derivatives with multiple biological effects and therapeutic applications in the central and peripheral nervous systems. One of these properties is the regulation of neuronal homeostasis and survival, which is the result of the combination of a myriad of effects addressed to preserve, rescue, repair, and/or replace neurons, and also glial cells against multiple insults that may potentially damage these cells. These effects are facilitated by the location of specific targets for the action of these compounds (e.g., cannabinoid type 1 and 2 receptors, endocannabinoid inactivating enzymes, and nonendocannabinoid targets) in key cellular substrates (e.g., neurons, glial cells, and neural progenitor cells). This potential is promising for acute and chronic neurodegenerative pathological conditions. In this review, we will collect all experimental evidence, mainly obtained at the preclinical level, supporting that different cannabinoid compounds may be neuroprotective in adult and neonatal ischemia, brain trauma, Alzheimer's disease, Parkinson's disease, Huntington's chorea, and amyotrophic lateral sclerosis. This increasing experimental evidence demands a prompt clinical validation of cannabinoid-based medicines for the treatment of all these disorders, which, at present, lack efficacious treatments for delaying/arresting disease progression, despite the fact that the few clinical trials conducted so far with these medicines have failed to demonstrate beneficial effects.

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“…Significantly increased free radical production is one of the main causes of secondary injury in TBI, leading to further damage to neuronal tissue and vasculature (Corps, Roth, & McGavern, 2015;Hiebert, Shen, Thimmesch, & Pierce, 2015). Evidence strongly suggests that oxidative stress induced by the imbalance between free radicals and antioxidants propagates secondary injury mechanisms in TBI (Deng, 2010).…”

Section: Evidence Reviewmentioning

confidence: 99%

Systematic Review of Traumatic Brain Injury and the Impact of Antioxidant Therapy on Clinical Outcomes

Shen

Hiebert

Hartwell

et al. 2016

Worldviews Ev Based Nurs

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Background: Traumatic brain injury (TBI) is an acquired brain injury that occurs when there is sudden trauma that leads to brain damage. This acute complex event can happen when the head is violently or suddenly struck or an object pierces the skull or brain. The current principal treatment of TBI includes various pharmaceutical agents, hyperbaric oxygen, and hypothermia. There is evidence that secondary injury from a TBI is specifically related to oxidative stress. However, the clinical management of TBI often does not include antioxidants to reduce oxidative stress and prevent secondary injury.

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Inflammation and Neuroprotection in Traumatic Brain Injury

Cited by 654 publications

References 66 publications

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications

Systematic Review of Traumatic Brain Injury and the Impact of Antioxidant Therapy on Clinical Outcomes

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