Inflammation and l-carnitine therapy in hemodialysis patients: a review

Khalatbari-Soltani, Saman; Tabibi, Hadi

doi:10.1007/s10157-014-1061-3

Cited by 29 publications

(26 citation statements)

References 51 publications

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“…Intestinal inflammation and microbiome disturbances may play a major role in chronic inflammation and in the consequences of adverse chronic kidney disease. A high concentration of serum inflammation markers is an important risk factor for CVD in hemodialysis patients . Several studies have been conducted to find treatment strategies for reducing inflammation in hemodialysis patients; however, no valid treatment has been found to‐date .…”

Section: Introductionmentioning

confidence: 99%

“…Probiotics are nonpathogenic live microorganisms given orally that establish residence in the gut; their presence is postulated to have beneficial effects on the host's health. Some of these suggested beneficial effects include: improving indigestion and lactose intolerance, cancer suppression, antimicrobial effects and immune system induction . Prebiotics, in distinction to probiotics, are indigestible food ingredients which are given in an attempt to stimulate growth and/or activity of beneficial gut bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…A high concentration of serum inflammation markers is an important risk factor for CVD in hemodialysis patients. [8][9][10][11][12] Several studies have been conducted to find treatment strategies for reducing inflammation in hemodialysis patients; however, no valid treatment has been found to-date. 4 Furthermore, in hemodialysis patients, one of the major risk factors for CVD is lipid abnormalities, including low serum high-density lipoprotein cholesterol (HDL-C), high serum triglyceride (TG), total cholesterol, and low-density lipoprotein cholesterol (LDL-C).…”

Section: Introductionmentioning

confidence: 99%

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A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

Kooshki

Tofighiyan

Miri

2019

Hemodialysis International

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Introduction: Among the most important risk factors for cardiovascular disease in hemodialysis patients are high concentrations of serum inflammation markers, lipid profiles, and oxidative stress. The present study aimed to investigate the effects of a synbiotic supplement on serum systemic inflammation, oxidative stress markers, and lipid profile in hemodialysis patients. Methods: Fifty hemodialysis patients were randomly allocated to synbiotic and placebo groups. The synbiotic group received 2 tablets per day of a synbiotic supplement (100 mg) Lactobacillus coagulans and fructo‐oligosaccharides for 8 weeks; whereas the placebo group received a similar appearing placebo. At the beginning and end of the study, 5 mL blood was taken after 12–14 hours of fasting. Findings: Mean values of serum C‐reactive protein (hs‐CRP) and malondialdehyde (MDA) significantly decreased in the synbiotic group at the end compared to the beginning of the study (P = 0.01). This reduction was significant in comparison with changes in the placebo group (P = 0.01). The synbiotic supplement also reduced serum total cholesterol (P = 0.001) and low‐density lipoprotein cholesterol (LDL‐c; P = 0.001) compared to the placebo group. Discussion: The synbiotic supplement used improves serum hs‐CRP and MDA, total cholesterol and LDL‐c in hemodialysis patients, which are known risk factors for cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

Kooshki

Tofighiyan

Miri

2019

Hemodialysis International

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“…Karnitin (hidroksi N trimetil aminobütirik asit) hayvansal kaynaklı besinlerin çoğunda bulunmaktadır ancak bitkisel kaynaklı besinlerde sınırlıdır (67). Karnitin ve inflamasyon arasındaki bağlantıya dair mekanizmalar net olmamasına karşın, karnitinin fazla ve toksik olan açil grupların vücuttan uzaklaştırılmasında rol alması ve serbest radikalleri süpürücü etkisinin olması; anti-inflamatuvar aktivitesinin altında yatan mekanizmalar olabileceği düşünülmektedir (68,69).…”

Section: Karnitinunclassified

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Öztürk¹,

Nergiz-Unal²

2018

Turk Neph Dial Transpl

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ÖZKronik böbrek hastalığı, glomerüler filtrasyonun azalmasıyla böbrekte sıvı-solüt dengesinin düzenlen-mesi ve metabolik-endokrin fonksiyonlarda kronik ve ilerleyici bozulma hali olarak tanımlanabilir. Kronik böbrek hastalığı gelişiminde rol alan inflamasyon, kronik böbrek hastalığının sonucu olarak da ortaya çıkabilmekte ve KBH varlığına bağlı mortalite artışının en önemli nedenlerinden biri olarak kabul edilmektedir. İnflamasyon ve diyet etkileşimi ile ilgili yapılan güncel araştırmalar çoklu doymamış yağ asitleri, D vitamini, E vitamini gibi besin ögeleri ile karnitin, lipoik asit, flavanoidler, probiyotikler ve prebiyotikler gibi diğer diyet bileşenlerinin renal inflamasyon sürecindeki olumlu etkilerine işaret etmektedir. Derlemede, olası anti-inflamatuvar bazı diyet bileşenlerinin kronik böbrek hastalığı ile ilişkili inflamasyon üzerine etkileri incelenmiştir. ANAHTAR SÖZCÜKLER: Kronik böbrek hastalığı, Beslenme, İnflamasyon, Diyet ABSTRACTChronic kidney disease can be defined as chronic and progressive deterioration of the regulation of fluid-solute balance and metabolic-endocrine functions of the kidney due to diminishing glomerular filtration. Inflammation in renal disease can develop as a cause or an outcome, and it has been reported in recent studies that inflammation is among the most important causes of disease-related mortality. Investigations on inflammation and diet interactions have shown that the effects of nutrients such as polyunsaturated fatty acids, vitamin D, vitamin E and other dietary components such as carnitine, lipoic acid, flavanoids, probiotics and prebiotics may have positive effects on the renal inflammation process. In this review, the potential anti-inflammatory effects of some current dietary components in chronic kidney disease were studied.

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“…В другом исследовании пероральный прием L-карнитина пациентами, получающими гемодиализ, улучшал не толь-ко ощущения мышечного дискомфорта, но также сопут-ствующие желудочно-кишечные расстройства и наруше-ния кишечного микробиоценоза [72]. Еще в одном иссле-довании [73] его авторы отмечают, что терапия L-карнитином является разумным подходом к снижению системного воспаления и его осложнений у пациентов на хроническом гемодиализе. Использование L-карнитина перед сеансами гемодиализа эффективно уменьшает число эпизодов внутридиализной гипотензии [74].…”

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Role and Location of L-Carnitine in Cytoprotection and Correction of Metabolic Processes in Patients With Metabolic Syndrome

Трухан¹

2017

Med. sov.

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ПРАКТИКАМ етаболический синдром (МС) характеризуется увеличением массы висцерального жира, сни-жением чувствительности периферических тканей к инсулину и гиперинсулинемией, которые вызы-вают развитие нарушений углеводного, липидного, пури-нового обменов и артериальной гипертонии (АГ).Основным критерием МС является центральный (абдоминальный) тип ожирения (объем талии более 80 см у женщин и более 94 см у мужчин). К дополнительным критериям МС относятся: уровень артериального давле-ния (АД) >140 и 90 мм рт. ст. или лечение артериальной гипертензии (АГ) препаратами; повышение уровня три-глицеридов (≥ 1,7 ммоль/л); снижение уровня ХС ЛПВП (<1,0 ммоль/л у мужчин; <1,2 ммоль/л у женщин); повы-шение уровня ХС ЛПНП > 3,0 ммоль/л; нарушенная толе-рантность к глюкозе (НТГ) -повышенный уровень глюко-зы плазмы через 2 ч после нагрузки 75 г безводной глюкозы при ПГТТ ≥ 7,8 и < 11,1 ммоль/л при условии, что уровень глюкозы плазмы натощак составляет менее 7,0 ммоль/л; нарушенная гликемия натощак (НГН) -повы-шенный уровень глюкозы плазмы натощак ≥ 6,1 и < 7,0 ммоль/л при условии, что глюкоза плазмы через 2 ч при ПГТТ составляет менее 7,8 ммоль/л; комбинированное нарушение НГН/НТГ -повышенный уровень глюкозы плазмы натощак ≥ 6,1 и < 7,0 ммоль/л в сочетании с глю-козой плазмы через 2 ч при ПГТТ ≥ 7,8 и < 11,1 ммоль/л. Достоверным МС считается при наличии 3 критериев: 1 основного и 2 дополнительных [1].Пациенты с МС имеют повышенный риск развития сердечно-сосудистых заболеваний (ССЗ) и сахарного диабета (СД) 2-го типа, что делает необходимым не толь-ко выявление, но и своевременную коррекцию этих состояний. Использование понятия МС дает возможность прогнозировать уровень распространенности ССЗ, смерт-ности вследствие ССЗ, СД 2-го типа и всех причин в опре-деленных популяциях во всем мире.Своевременная диагностика и коррекция отдельных компонентов МС предотвращает развитие и прогресси-рование тяжелых кардиоваскулярных заболеваний и их осложнений. Терапевтические мероприятия при лечении Ключевые слова: метаболический синдром, регуляция метаболизма, цитопротекция, органопротекция, L-карнитин. ROLE AND LOCATION OF L-CARNITINE IN CYTOPROTECTION AND CORRECTION OF METABOLIC PROCESSES IN PATIENTS WITH METABOLIC SYNDROME Trukhan D.I.Patients with metabolic syndrome (MS) have an increased risk of developing cardiovascular diseases and type 2 diabetes mellitus, which makes it necessary not only to identify, but also to timely correct these conditions. Therapeutic measures in the treatment of patients with MS are directed to the main links of the pathogenesis of the syndrome and its complications: obesity, insulin resistance, violation of carbohydrate metabolism, dyslipidemia and arterial hypertension. Meanwhile, the niche remains for multi-potent drugs, simultaneously affecting several risk factors, united by a single pathogenetic basis. As a possible candidate, L-carnitine can be considered. The review describes cardioprotective, neuroprotective, nephroprotective and hepatoprotective effects of L-carnitine, its favorable effect on carbohyd...

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Inflammation and l-carnitine therapy in hemodialysis patients: a review

Cited by 29 publications

References 51 publications

A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Role and Location of L-Carnitine in Cytoprotection and Correction of Metabolic Processes in Patients With Metabolic Syndrome

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