Inflammation and immune response in acute aortic dissection

Porto, Flavia Del; Proietta, Maria; Tritapepe, Luigi; Miraldi, Fabio; Koverech, Aleardo; Cardelli, Patrizia; Tabacco, Fabio; Santis, Vincenzo De; Vecchione, Andrea; Mitterhofer, Anna Paola; Nofroni, Italo; Amodeo, Rachele; Trappolini, M; Aliberti, Giuseppe

doi:10.3109/07853890.2010.518156

Cited by 151 publications

(137 citation statements)

References 35 publications

Supporting

Mentioning

125

Contrasting

Order By: Relevance

“…Two risk models including preoperative and intraoperative variables have been developed by the International Registry of Acute Aortic Dissection and are generally used, but in recent studies several biochemical markers of vascular injury, thrombosis, and inflammation have been evaluated as contributors in the diagnosis of acute aortic dissection or as risk prediction tools. These studies suggest that AAD is associated with both tissue-level and systemic inflammatory reaction, and one of the inflammatory markers, C-reactive protein (CRP), is a useful marker to predict in-hospital and long-term adverse events (3)(4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

Lafçı¹,

Çiçek²,

Uzun³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

vitro, the amino acids glutamic acid, aspartic acid, alanine, glutamine, proline, serine, and arginine induced rooting of explants in the presence of a-naphthalene acetic acid (Kamada and Harada 1979). Furthermore, it was found that while proline (10-200 mg L -1 ) increased the rooting percentage and number of roots per rooted explant of sweet cherry (Prunus avium L.) and sour cherry (Prunus cerasus L.), the root length was reduced (Baraldi et al. 1988).The different forms of nitrogen as well as its proportion can influence a number of factors in various in vitro cultures, such as cell division, the growth and development of somatic embryos, chlorophyll content, ribulose-1, 5-bisphosphate carboxylase/oxygenase activity, the electron transport rate, the photosynthetic rate, fresh mass, soluble protein concentration, and the osmotic pressure of the cell sap (Mashayekhi-Nezamabadi 2000). It has been reported that reduced nitrogen forms, particularly amides and amino acids, can improve cell proliferation, as well as regeneration in specific genotypes (Vasudevan et al. 2004).Methionine, a sulfur-containing amino acid, is a precursor of ethylene biosynthesis in plant tissues (Yang 1985). Besides its function as a protein constituent and its central role in the initiation of mRNA translation, methionine indirectly regulates a range of cellular processes as the precursor of S-adenosylmethionine (SAM) (Amir et al. 2002). Not only is SAM the primary biological methyl-group donor, but it is also the precursor of plant metabolites, including ethylene, polyamines, vitamin B 1 , and the iron chelator mugineic acid (Sun Abstract: In the present study, the effects of indole-3-butyric acid (IBA) alone and in combination with L-methionine were investigated on the morphogenic and biochemical responses in the shoot tip explants of the cherry rootstocks CAB-6P (Prunus cerasus L.) and Gisela 6 (Prunus cerasus × Prunus canescens). The best results for roots, regarding their number and the fresh and dry weight, were obtained with 2 mg L -1 IBA in both rootstocks. Maximum rooting percentage was with the combination of 2 mg L -1 IBA and 0.5 mg L -1 L-methionine. Root length was greatest in the control plants. L-methionine had an inhibitory effect on the leaf chlorophyll content of the CAB-6P rootstock and no effect in Gisela 6. L-methionine with the lowest IBA concentration (0.5 mg L -1 ) exhibited elevated levels of proline in the roots of the CAB-6P rootstock and depleted levels in Gisela 6. For the Gisela 6 rootstock, the leaf carbohydrate concentration was highest with 2 mg L -1 of IBA, whereas in the roots it was highest in the control. For the CAB-6P rootstock, the leaf carbohydrate concentration was not influenced by IBA with L-methionine, whereas the highest carbohydrate concentration in the roots was with the combinations of 0.5 mg L -1 IBA and 1 and 2 mg L -1 L-methionine. Taking into account the different parameters examined, it appears that chlorophyll and carbohydrates are the most accurate biochemical markers of the rooting ...

show abstract

Section: Introductionmentioning

confidence: 99%

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

Lafçı¹,

Çiçek²,

Uzun³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…This condition may determine the reduction of perfusion of numerous organs with devastating complications (1-3). Recent evidence suggests inflammation as the principal mechanism of aorta AD medial degeneration (6,(9)(10)(11)(12). In particular, it has been demonstrated that inflammatory cells, such as lymphocytes and macrophages, not only increase the expression of proteases and cell adhesion molecules, but also release reactive oxygen species.…”

mentioning

confidence: 99%

“…In particular, it has been demonstrated that inflammatory cells, such as lymphocytes and macrophages, not only increase the expression of proteases and cell adhesion molecules, but also release reactive oxygen species. Thus, they contribute to the apoptosis of vascular smooth muscle cells (VSMCs) in the aortic artery, and finally lead to medial degradation (6,(9)(10)(11)(12). Furthermore, this condition determines increases in systemic inflammatory molecules [i.e.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The Role of Inflammation in Type a Aortic Dissection: A Pilot Study

et al. 2013

View full text Add to dashboard Cite

Type A aortic dissection (TAAD) is a severe cardiovascular disease with high mortality rates. Current evidence suggests inflammation as the main mechanism of its complex pathophysiology. Accordingly, in this study the eventual presence of inflammatory cells in aorta specimens and any contribution of these cells in both apoptosis and metalloproteinase levels were assessed. The potential relationship between plasma inflammatory molecules and TAAD was also detected. In addition, implication in TAAD susceptibility of ten common and functional single nucleotide polymorphisms (SNP)s of six candidate genes (CCR5, TLR4, ACE, eNOs, MMP-9 and -2) was determined. Thus, histo-pathological and immunoistochemical aorta examination, TUNEL testing, genotyping of ten SNPs were performed. Levels of plasma inflammatory molecules were also determined using ELISA technique. A significant inflammatory infiltrate was observed in the examined aortas. Consistent with these data, significantly higher plasma levels of systemic inflammatory mediators characterized the cases. In addition, a high risk genotype significantly associated with TAAD susceptibility was identified. Thus, inflammation producing MMPs, cytokines and death mediators seem to be the shared pathological mechanism for TAAD in the population examined.

show abstract

“…This phase is mediated as well by tumor necrosis factor-alpha, interleukin (IL)-6, IL-8 and macrophage metalloprotease-12, which participate in tissue breakdown and augment the local inflammation. [13][14][15] On the other hand, areas of chronic response with appearance of granulation tissue, new capillaries and collagen deposition are building up in the outer layers of media. This type of reaction can be demonstrated only days or weeks after the initial assault, and its biological significance may consist of the separation of the damaged area and strengthening of the surrounding structures.…”

Section: Discussionmentioning

confidence: 99%

Chronic Stanford type A aortic dissection manifesting as systemic inflammatory disorder

et al. 2016

View full text Add to dashboard Cite

Inflammation and immune response in acute aortic dissection

Abstract: Our results strongly support the hypothesis of a pivotal role of innate immunity in type-A Stanford AAD.

Cited by 151 publications

References 35 publications

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

The Role of Inflammation in Type a Aortic Dissection: A Pilot Study

Chronic Stanford type A aortic dissection manifesting as systemic inflammatory disorder

Contact Info

Product

Resources

About