Inflammation and focal atrophy in prostate needle biopsy cores and association to prostatic adenocarcinoma

Benedetti, Inés; Bettin, Alfonso; Reyes, Niradiz

doi:10.1016/j.anndiagpath.2016.04.010

Cited by 13 publications

(5 citation statements)

References 49 publications

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“…It is commonly in proximity to cancer, and proliferative inflammatory atrophy is proposed as a precursor to HGPIN and cancer. Like inflammation, studies on the association of atrophy and cancer showed both positive 35,44 and negative 45‐48 associations. In a prior study, 12 we showed that whenever atrophy abutted cancer, it was disproportionately close to Gleason pattern 3 cancer foci even after adjusting for the lesser frequency of higher‐grade cancer foci in the study.…”

Section: Discussionmentioning

confidence: 99%

Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low‐grade cancer

Palangmonthip

Tarima

et al. 2020

The Prostate

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Background: Corpora amylacea (CAM), in benign prostatic acini, contain acutephase proteins. Do CAM coincide with carcinoma?Methods: Within 270 biopsies, 83 prostatectomies, and 33 transurethral resections (TURs), CAM absence was designated CAM 0; corpora in less than 5% of benign acini: CAM 1; in 5% to 25%: CAM 2; in more than 25%: CAM 3. CAM were compared against carcinoma presence, clinicopathologic findings, and grade groups (GG) 1 to 2 vs 3 to 5.The frequency of CAM according to anatomic zone was counted. A pilot study was conducted using paired initial benign and repeat biopsies (33 benign, 24 carcinoma).Results: A total of 68.9% of biopsies, 96.4% of prostatectomies, and 66.7% of TURs disclosed CAM. CAM ≥1 was common at an older age (P = .019). In biopsies, 204 cases (75%) had carcinoma; and CAM of 2 to 3 (compared to 0-1) were recorded in 25.0% of carcinomas but only 7.4% of benign biopsies (P = .005; odds ratio [OR] = 5.1). CAM correlated with high percent Gleason pattern 3, low GG (P = .035), and chronic inflammation (CI). CI correlated inversely with carcinoma (P = .003). CAM disclosed no association with race, body mass index, serum prostate specific antigen (PSA), acute inflammation (in biopsies), atrophy, or carcinoma volume.With CAM 1, the odds of GG 3 to 5 carcinoma, by comparison to CAM 0, decreased more than 2× (OR = 0.48; P = .032), with CAM 2, more than 3× (OR = 0.33; P = .005), and with CAM 3, almost 3× (OR = 0.39, P = .086). For men aged less than 65, carcinoma predictive model was: Score = (2 × age) + (5 × PSA) − (20 × degree of CAM); using our data, area under the ROC curve was 78.17%. When the transition zone was involved by cancer, it showed more CAM than in cases where it was uninvolved (P = .012); otherwise zonal distributions were similar.In the pilot study, CAM ≥1 predicted carcinoma on repeat biopsy (P < .05; OR = 8), as did CAM 2 to 3 (P < .0001; OR = 30). CI was not significant, and CAM retained significance after adjusting for CI. Conclusion: CAM correlate with carcinoma. Whether abundant CAM in benign biopsies adds value amidst high clinical suspicion, warrants further study. K E Y W O R D S corpora amylacea, inflammation, peripheral zone, prediction of cancer, prostate cancer, transition zone 688 | PALANGMONTHIP ET AL.

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Section: Discussionmentioning

confidence: 99%

Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low‐grade cancer

Palangmonthip

Tarima

et al. 2020

The Prostate

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“…While there are well‐established models of inflammation leading to carcinogenesis in hepatocellular, cervical, oesophageal and gastric carcinomas, the role of inflammation in PCa development has remained unclear. Although some authors have reported higher odds of PCa in cases in which at least one biopsy core had the presence of moderate or severe inflammation , a recent meta‐analysis of 25 studies concluded that histological inflammation on prostate needle biopsies was associated with a lower risk of subsequent PCa diagnosis . Beyond cancer risk for those who are eventually diagnosed with PCa, Moreira et al found the presence of chronic inflammatory infiltrate in the biopsy was associated with lower tumour volumes.…”

Section: Discussionmentioning

confidence: 99%

Both acute and chronic inflammation are associated with less perineural invasion in men with prostate cancer on repeat biopsy

et al. 2018

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“…Inflammation is a complex pathologic process usually accompanying other diseases, and long-term inflammation increases the risk of cancer [ 48 , 49 ]. This complexity means that resolution of inflammation is not enough to eradicate diseases.…”

Section: Discussionmentioning

confidence: 99%

Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses

Shen

Zhao

Wang

et al. 2017

Mediators of Inflammation

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Objective. This study was aimed at elucidating the molecular mechanisms underlying the anti-inflammatory effect of the combined application of Bupleuri Radix and Scutellariae Radix and explored the potential therapeutic efficacy of these two drugs on inflammation-related diseases. Methods. After searching the databases, we collected the active ingredients of Bupleuri Radix and Scutellariae Radix and calculated their oral bioavailability (OB) and drug-likeness (DL) based on the absorption-distribution-metabolism-elimination (ADME) model. In addition, we predicted the drug targets of the selected active components based on weighted ensemble similarity (WES) and used them to construct a drug-target network. Gene ontology (GO) analysis and KEGG mapper tools were performed on these predicted target genes. Results. We obtained 30 compounds from Bupleuri Radix and Scutellariae Radix of good quality as indicated by ADME assays, which possess potential pharmacological activity. These 30 ingredients have a total of 121 potential target genes, which are involved in 24 biological processes related to inflammation. Conclusions. Combined application of Bupleuri Radix and Scutellariae Radix was found not only to directly inhibit the synthesis and release of inflammatory cytokines, but also to have potential therapeutic effects against inflammation-induced pain. In addition, a combination therapy of these two drugs exhibited systemic treatment efficacy and provided a theoretical basis for the development of drugs against inflammatory diseases.

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Inflammation and focal atrophy in prostate needle biopsy cores and association to prostatic adenocarcinoma

Cited by 13 publications

References 49 publications

Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low‐grade cancer

Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low‐grade cancer

Both acute and chronic inflammation are associated with less perineural invasion in men with prostate cancer on repeat biopsy

Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses

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