Inflammation and Degeneration in Cartilage Samples from Patients with Femoroacetabular Impingement

Chinzei, Nobuaki; Hashimoto, Shingo; Fujishiro, Takaaki; Hayashi, Shinya; Kanzaki, Noriyuki; Uchida, Soshi; Kuroda, Ryosuke; Kurosaka, Masahiro

doi:10.2106/jbjs.o.00443

Cited by 39 publications

(64 citation statements)

References 29 publications

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“…However, the study found that levels of collagen type I alpha 1 (COL1A1) were greater in cartilage from OA specimens without FAI compared with FAI specimens (P<0.01) 11. Regarding the ACAN biomarker, one study found that levels were greater in FAI specimens,12 while another study found that levels were greater in OA specimens with no FAI (P<0.05) 11…”

Section: Resultsmentioning

confidence: 97%

“…Furthermore, another study investigating biomarkers within articular cartilage found that levels of interleukin-1 beta (IL-1β), interleukin-8 (IL-8), matrix metalloproteinase-13, ADAMTS-4 and CCL3L1 were greater within FAI specimens compared with OA specimens with no signs of FAI (P<0.05) 11. However, the study found that levels of collagen type I alpha 1 (COL1A1) were greater in cartilage from OA specimens without FAI compared with FAI specimens (P<0.01) 11. Regarding the ACAN biomarker, one study found that levels were greater in FAI specimens,12 while another study found that levels were greater in OA specimens with no FAI (P<0.05) 11…”

Section: Resultsmentioning

confidence: 99%

“…Of the two studies investigating biomarkers within the acetabular labrum,11 18 one study found that levels of IL-1β, IL-8, MMP-3 and COL1A1 were greater in OA specimens compared with FAI specimens (P<0.05) 11. The other study found that levels of IL-13, CD34, vascular endothelial growth factor (VEGF), M2 macrophages and mast cells were greater in labrum samples from FAI specimens compared with OA specimens with no signs of FAI (P<0.05) 18…”

Section: Resultsmentioning

confidence: 99%

“…One study found that levels of IL-1β, IL-811 and matrix metalloproteinase-3 (MMP-3) were greater in the synovial fluid from OA specimens compared with FAI specimens (P<0.05). Another study reported that fibronectin–aggrecan complex (FAC) levels were higher in patients with FAI and no radiographic signs of OA compared with patients with radiographic evidence of OA (P<0.05) 16.…”

Section: Resultsmentioning

confidence: 99%

“…One study compared biomarker concentrations between cartilage,11 labrum and synovium samples from patients with FAI and found that IL-1β and IL-8 were greater within the cartilage compared with the labrum and synovium (P<0.01). Additionally, this study found that levels of IL-8 in cartilage were greater in patients over 30 years of age compared with patients less than 30 years of age (P<0.05).…”

Section: Resultsmentioning

confidence: 99%

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Biomarkers in the serum, synovial fluid and articular cartilage show promising utility in patients with femoroacetabular impingement: a systematic review

et al. 2018

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ImportanceBiomarkers have promising potential to provide a cost-effective tool to identify patients with femoroacetabular impingement (FAI) who are most at risk and who may benefit most from early joint preservation surgery.ObjectiveTo assess the potential role of biomarkers in the diagnosis and prognosis of FAI.Evidence reviewThree databases (PubMed, Ovid (MEDLINE) and Embase) were searched on 20 August 2017 from database inception, and two reviewers independently and in duplicate screened the resulting literature. Methodological quality of all included papers was assessed using the Methodological Index for Non-Randomized Studies criteria. The results are presented in a narrative summary fashion using descriptive statistics including means, proportions and ranges.FindingsSeven studies (one retrospective laboratory series and six controlled laboratory studies) were identified including a total of 227 patients. The mean age of the patients was 41.6 years (range: 13–80), with a mean follow-up period of 29.9 months (SD=3.2). Markers of articular cartilage breakdown, including cartilage oligomeric matrix protein (COMP) and fibronectin–aggrecan complex (FAC), were identified in high concentrations in the serum and synovial fluid of patients with FAI, respectively. Moreover, mRNA expression of catabolic cytokines in the articular cartilage of patients with FAI has been reported.Conclusions and relevanceAlthough not yet used in clinical settings, several biomarkers of articular cartilage damage have been identified in the serum, synovial fluid and articular cartilage of patients with FAI. These findings provide promising insight into the potential role of biomarkers in guiding clinical practice and assisting with patient selection and preoperative counselling in patients with FAI and should be evaluated further.Level of evidenceIV, systematic review of level III and IV studies.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Biomarkers in the serum, synovial fluid and articular cartilage show promising utility in patients with femoroacetabular impingement: a systematic review

et al. 2018

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No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement

Talks

Fernquest

Palmer

et al. 2019

Journal Orthopaedic Research

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Femoroacetabular impingement (FAI) is a common cause of hip pain and represents a major cause of early osteoarthritis. The role of systemic inflammation in pre‐arthritic hip conditions remains largely unknown and uninvestigated. Serum‐free light chains (sFLCs) are inflammatory markers produced by B cells. This study aimed to determine whether there was evidence of systemic inflammation in patients with FAI, defined by sFLCs, and whether this correlated with markers of disease severity. Participants for this study were recruited from a single center (Nuffield Orthopedic Center, Oxford) and were taking part in the Femoroacetabular Impingement Trial. The cohort comprised 115 individuals (38 male, 77 female, mean age 37 years): 57 individuals received surgical intervention and 58 received physiotherapy. All individuals provided patient‐reported outcome measures and serum samples at baseline and follow‐up 8 months post‐randomization. sFLC concentrations were measured in serum samples by immunoturbidimetry. At baseline, for all individuals, mean polyclonal sFLC concentrations were 30.36 mg/l (standard deviation [SD] 9.23). At follow‐up, the mean polyclonal sFLC concentrations were 31.68 mg/l (SD 9.61) in the surgical intervention cohort, and 29.48 mg/l (SD 7.85) in the physiotherapy intervention cohort. There was no significant correlation between sFLC concentrations and any of the patient reported outcome measures, or radiographic measures: average or maximum alpha angle, or center edge angle. In conclusion, in patients with symptomatic FAI there was no systemic inflammation, as defined by sFLC concentrations, and no correlation between sFLC concentrations and measures of disease severity. The lack of inflammation suggests FAI is a mechanical phenomenon. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2189–2196, 2019

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RE: Talks BJ, Fernquest S, Palmer A, et al. 2019. No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement

Mendias

Bedi

2019

Journal Orthopaedic Research

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Inflammation and Degeneration in Cartilage Samples from Patients with Femoroacetabular Impingement

Abstract: The articular cartilage from the impingement lesion in patients with FAI showed biologically higher inflammation and degeneration, supporting the concept that FAI may be a trigger for joint degeneration.

Cited by 39 publications

References 29 publications

Biomarkers in the serum, synovial fluid and articular cartilage show promising utility in patients with femoroacetabular impingement: a systematic review

Biomarkers in the serum, synovial fluid and articular cartilage show promising utility in patients with femoroacetabular impingement: a systematic review

No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement

RE: Talks BJ, Fernquest S, Palmer A, et al. 2019. No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement

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