Inflammation and Cognitive Functioning in Depressed Older Adults Treated With Electroconvulsive Therapy

Carlier, Angela; Rhebergen, Didi; Veerhuis, Robert; Schouws, Sigfried; Oudega, Mardien L.; Eikelenboom, Piet; Bouckaert, Filip; Sienaert, Pascal; Obbels, Jasmien; Stek, Max L.; Exel, Eric van; Dols, Annemiek

doi:10.4088/jcp.20m13631

Cited by 11 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Survivors who were more depressed had poorer attention on the CPT, lower verbal fluency on the FAS test and animal-naming test, worse recall on the HVLT, poorer working memory on the 2-back, and more difficulties with visuospatial search on the trail-making tests. In contrast to other literature [21][22][23]26], inflammation alone did not reliably predict neuropsychological testing performance, except for two marginally non-significant effects. These null results are surprising considering our inclusion of three inflammatory variables to better index the inflammatory burden, compared to other studies that have only used a single marker.…”

Section: Discussioncontrasting

confidence: 99%

“…Unlike prior research [21][22][23]26], our inflammatory index was not directly related to subjective or objective measures. We looked cross-sectionally, whereas inflammation's cognitive effect may play out longitudinally [26].…”

Section: Discussionmentioning

confidence: 69%

“…Clinically elevated inflammation accompanies at least 25% of depression cases [19], and the two may reciprocally reinforce one another [20]-a difficult-to-treat immune-mediated depression subtype. Previous studies have demonstrated a relationship between higher inflammation and cognitive deficits among depressed individuals [21][22][23]. Depression and inflammation may each heighten the risk for cognitive problems; thus, the combination may be particularly detrimental.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship

Madison,

Andridge,

Kantaras

et al. 2023

Cancers

View full text Add to dashboard Cite

About one-in-three breast cancer survivors have lingering cognitive complaints and objective cognitive impairment. Chronic inflammation and intestinal permeability (i.e., leaky gut), two risk factors for cognitive decline, can also fuel depression—another vulnerability for cognitive decline. The current study tested whether depression accompanied by high levels of inflammation or intestinal permeability predicted lower subjective and objective cognitive function in breast cancer survivors. We combined data from four breast cancer survivor studies (n = 613); some had repeated measurements for a total of 1015 study visits. All participants had a blood draw to obtain baseline measures of lipopolysaccharide binding protein—a measure of intestinal permeability, as well as three inflammatory markers that were incorporated into an inflammatory index: C-reactive protein, interleukin-6, and tumor necrosis factor-α. They reported depressive symptoms on the Center for Epidemiological Studies depression scale (CES-D), and a binary variable indicated clinically significant depressive symptoms (CES-D ≥ 16). The Kohli (749 observations) and the Breast Cancer Prevention Trial (591 observations) scales assessed subjective cognitive function. Objective cognitive function tests included the trail-making test, Hopkins verbal learning test, Conners continuous performance test, n-back test, FAS test, and animal-naming test (239–246 observations). Adjusting for education, age, BMI, cancer treatment type, time since treatment, study visit, and fatigue, women who had clinically elevated depressive symptoms accompanied by heightened inflammation or intestinal permeability reported poorer focus and marginally poorer memory. However, poorer performance across objective cognitive measures was not specific to inflammation-associated depression. Rather, there was some evidence of lower verbal fluency; poorer attention, verbal learning and memory, and working memory; and difficulties with visuospatial search among depressed survivors, regardless of inflammation. By themselves, inflammation and intestinal permeability less consistently predicted subjective or objective cognitive function. Breast cancer survivors with clinically significant depressive symptoms accompanied by either elevated inflammation or intestinal permeability may perceive greater cognitive difficulty, even though depression-related objective cognitive deficits may not be specific to inflammation- or leaky-gut-associated depression.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship

Madison,

Andridge,

Kantaras

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…"This study assessed whether inflammatory markers prior to ECT are associated with cognitive functioning in depressed patients treated with ECT." (Carlier, 2021) Repetitive transcranial magnetic stimulation (rTMS)…”

Section: Electroconvulsive Therapy (Ect)mentioning

confidence: 99%

PROTOCOL: Non‐pharmacological interventions for older people with a diagnosis of depression: An evidence and gap map

Shang,

Guo,

Liu

et al. 2023

Campbell Systematic Reviews

View full text Add to dashboard Cite

show abstract

“…A serious concern regarding this intervention is related to cognitive impairment in older patients, which was found to be greater when baseline CRP and cytokine levels were higher, in a prospective cohort study [ 191 ].…”

Section: Electroconvulsive Therapy (Ect)mentioning

confidence: 99%

Current Perspectives on Pharmacological and Non-Pharmacological Interventions for the Inflammatory Mechanism of Unipolar Depression

et al. 2022

View full text Add to dashboard Cite

Since depression remains a major public health issue there is a constant need for new and more efficient therapeutic strategies based on the mechanisms involved in the aetiology of depression. Thus, the pathogenic link between depression and inflammation is considered to play a potential key role in the development of such therapies. This review summarizes the results of various pharmacological (non-steroidal anti-inflammatory drugs, aspirin, cyclooxygenase inhibitors, cytokine inhibitors, corticosteroids, statins, minocycline, N-acetyl cysteine, omega-3 fatty acids and probiotics) and non-pharmacological interventions (electroconvulsive therapy, physical exercise and psychological therapy) and outlines their efficacy and discusses potential challenges. Both conventional and non-conventional anti-inflammatory drugs showed promising results according to the specific group of patients. The pre-existing pro-inflammatory status was, in most cases, a predictor for clinical efficacy and, in some cases, a correlation between clinical improvement and changes in various biomarkers was found. Some of the non-pharmacological interventions (physical exercise and electroconvulsive therapy) have also showed beneficial effects for depressive patients with elevated inflammatory markers. Treatments with anti-inflammatory action may improve clinical outcomes in depression, at least for some categories of patients, thus opening the way for a future personalised approach to patients with unipolar depression regarding the inflammation-related mechanism.

show abstract

Inflammation and Cognitive Functioning in Depressed Older Adults Treated With Electroconvulsive Therapy

Cited by 11 publications

References 0 publications

Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship

Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship

PROTOCOL: Non‐pharmacological interventions for older people with a diagnosis of depression: An evidence and gap map

Current Perspectives on Pharmacological and Non-Pharmacological Interventions for the Inflammatory Mechanism of Unipolar Depression

Contact Info

Product

Resources

About