Inflammation and cardiovascular disease: are marine phospholipids the answer?

Lordan, Ronan; Redfern, Shane; Τσούπρας, Αλέξανδρος; Zabetakis, Ioannis

doi:10.1039/c9fo01742a

Cited by 73 publications

(86 citation statements)

References 274 publications

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“…N-3 PUFAs and many of the their endogenously generated metabolites act as bioactive lipid molecules with a wide array of properties against numerous disorders including CVD ( Lordan, Redfern, Tsoupras, & Zabetakis, 2020 ; Lordan, Tsoupras, & Zabetakis, 2017 ; Moro, Nagahashi, Ramanathan, Takabe, & Wakai, 2016 ). Numerous studies have suggested higher consumption of n-3 PUFAs lowers the number of mortalities related to CVD ( Darwesh, Sosnowski, Lee, Keshavarz-Bahaghighat, & Seubert, 2019 ; Kris-Etherton, Harris, Appel, & Nutrition, 2003 ; Lee, O'Keefe, Lavie, & Harris, 2009 ; Mozaffarian, 2007 ).…”

Section: Cardiovascular Benefits Of N-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

“…Within a cell, n-3 PUFAs can be found incorporated into phospholipid membranes where elevating levels will replace existing n-6 PUFAs thereby altering the composition and properties of lipid rafts ( Lordan et al, 2017 ; Lordan et al, 2020 ). The increased incorporation of n-3 PUFAs into membrane bilayers can have a role in mediating immunomodulatory effects by altering membrane composition, fluidity and function.…”

Section: Potential Cardioprotective Mechanisms Of N-3 Pufas In the Sementioning

confidence: 99%

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Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

Darwesh

Bassiouni

Sosnowski

et al. 2021

Pharmacology & Therapeutics

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Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has currently led to a global pandemic with millions of confirmed and increasing cases around the world. The novel SARS-CoV-2 not only affects the lungs causing severe acute respiratory dysfunction but also leads to significant dysfunction in multiple organs and physiological systems including the cardiovascular system. A plethora of studies have shown the viral infection triggers an exaggerated immune response, hypercoagulation and oxidative stress, which contribute significantly to poor cardiovascular outcomes observed in COVID-19 patients. To date, there are no approved vaccines or therapies for COVID-19. Accordingly, cardiovascular protective and supportive therapies are urgent and necessary to the overall prognosis of COVID-19 patients. Accumulating literature has demonstrated the beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFA) toward the cardiovascular system, which include ameliorating uncontrolled inflammatory reactions, reduced oxidative stress and mitigating coagulopathy. Moreover, it has been demonstrated the n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are precursors to a group of potent bioactive lipid mediators, generated endogenously, which mediate many of the beneficial effects attributed to their parent compounds. Considering the favorable safety profile for n-3 PUFAs and their metabolites, it is reasonable to consider n-3 PUFAs as potential adjuvant therapies for the clinical management of COVID-19 patients. In this article, we provide an overview of the pathogenesis of cardiovascular complications secondary to COVID-19 and focus on the mechanisms that may contribute to the likely benefits of n-3 PUFAs and their metabolites.

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Section: Cardiovascular Benefits Of N-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Section: Potential Cardioprotective Mechanisms Of N-3 Pufas In the Sementioning

confidence: 99%

Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

Darwesh

Bassiouni

Sosnowski

et al. 2021

Pharmacology & Therapeutics

View full text Add to dashboard Cite

show abstract

“…Although it is known that omega fatty acids are a potent candidate for the therapeutic interaction with COX enzymes [51], its role in SARS-CoV-2 infection needs more in-depth studies to use as human trials.…”

Section: Omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention

2020

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Purpose of Review An unexpected and sudden outbreak of a novel infection known as a coronavirus (COVID-19) has imposed important problems to global well-being and economy. Based upon current researches, this virus is spreading from one human to another through respiratory droplets, i.e. cough and sneeze. Till now, there has not been any specific treatment found for this virus. Hence, there is a critical need to discover alternative techniques to cope with the current scenario. Recent Findings This review conducted an online search for prevention of coronavirus infection with the help of nutritional interventions. It has been observed that the effect of the virus is mostly on the individual with low immunity, individual affected with diseases like diabetes, and individual using any immune-suppressed drug or having past history of major surgeries or severe medical conditions. Summary Therefore, consuming foods which boost immunity helps in preventing respiratory-related disorder or suppressing diseases-related problems, which could be helpful in controlling the spread of this virus. In conclusion, it has been suggested that before the beginning of generalised treatments and interventions in each infected patient, nutritional status should be evaluated, as it can help in creating a specific nutrition intervention for the infected individual.

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“…Both EPA and DHA exert beneficial effects on various inflammatory diseases, such as Alzheimer’s disease [ 19 ], cardiovascular diseases [ 20 ], cancer [ 21 , 22 ], diabetes [ 23 , 24 ], thrombosis [ 12 , 17 , 18 ], and inflammatory activity [ 25 , 26 ]. A recent research study has reported that when n-3 PUFA binds with polar lipids, it exerts differential bioavailability and biological effects upon consumption in contrast to neutral forms of n-3 PUFA [ 27 ]. Similarly, in vivo studies have also found that when n-3 PUFA binds with polar lipids, it becomes more bioavailable and bioactive than n-3 PUFA bound to TAG [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Neutral Lipids, Glycolipids, and Phospholipids, Isolated from Sandfish (Arctoscopus japonicus) Eggs, Exhibit Anti-Inflammatory Activity in LPS-Stimulated RAW264.7 Cells through NF-κB and MAPKs Pathways

et al. 2020

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Total lipids were extracted from sandfish (Arctoscopus japonicus), and then they were separated into the following three lipid fractions: neutral lipids, glycolipids, and phospholipids. In this study, we analyzed the lipid fractions of A. japonicus eggs and we determined their anti-inflammatory activity in RAW264.7 macrophage cells. In these three lipid-fractions, the main fatty acids were as follows: palmitic acid (16:0), oleic acid (18:1n-9), docosahexaenoic acid (DHA, 22:6n-3), and eicosapentaenoic acid (EPA, 20:5n-3). Among the lipid fractions, phospholipids showed the highest concentration of DHA and EPA (21.70 ± 1.92 and 18.96 ± 1.27, respectively). The three lipid fractions of A. japonicus significantly suppressed the production of NO in macrophages. Moreover, they also significantly inhibited the expression of iNOS, COX-2, IL-6, IL-1β, and TNF-α, in a dose-dependent manner. Furthermore, the lipid fractions of A. japonicus suppressed the nuclear translocation of NF-κB p65 subunits in a dose-dependent manner. In addition, they attenuated the activation of MAPKs (p38, ERK1/2, and JNK) phosphorylation in LPS-stimulated RAW264.7 cells. These results indicate that all the lipid fractions of A. japonicus exert anti-inflammatory activity by suppressing the activation of NF-κB and MAPK pathways. Therefore, the lipid fractions of A. japonicus might be potentially used as anti-inflammatory agents.

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Inflammation and cardiovascular disease: are marine phospholipids the answer?

Abstract: This review presents the latest research on the cardioprotective effects of n-3 fatty acids (FA) and n-3 FA bound to polar lipids (PL). Overall, n-3 PL may have enhanced bioavailability and potentially bioactivity versus free FA and ester forms of n-3 FA.

Cited by 73 publications

References 274 publications

Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention

Neutral Lipids, Glycolipids, and Phospholipids, Isolated from Sandfish (Arctoscopus japonicus) Eggs, Exhibit Anti-Inflammatory Activity in LPS-Stimulated RAW264.7 Cells through NF-κB and MAPKs Pathways

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