Inflammation and cardiac insufficiency associated with infectious endocarditis

Fedorova, T.A.; Tazina, Serafima Ya.; Kakturskiy, L. V.; Kanareĭtseva, T D; Stefanenko, N. I.; Burtsev, V. I.; Semenenko, N. A.

doi:10.18821/0023-2149-2016-94-1-23-27

Cited by 3 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The severe and rapid progression of the endocarditic process in this population is intriguing, given the low inflammatory process and the bacterial profile. This contrasts with previous published studies reporting a correlation between the severity of inflammation and the importance of valvular destruction and embolic complications [19][20][21][22][23][24][25]. This was probably related to a population selection 10 bias in these studies, because TOE was only performed in symptomatic patients with unexplained severe valvular lesions or with systemic embolic events.…”

Section: Discussioncontrasting

confidence: 77%

Infective endocarditis without biological inflammatory syndrome: Description of a particular entity

Ribeyrolles

Ternacle

San

et al. 2019

Archives of Cardiovascular Diseases

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 77%

Infective endocarditis without biological inflammatory syndrome: Description of a particular entity

Ribeyrolles

Ternacle

San

et al. 2019

Archives of Cardiovascular Diseases

View full text Add to dashboard Cite

“…A total of 14 were finally excluded due to the causes explained in Supplementary material online, Appendix SII. A total of 18 studies met all our inclusion criteria, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] although only 9 were suitable for the quantitative meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…1 Recently small series describing the prevalence and significance of cardiac troponin (Tn) elevation in patients with IE have been published, suggesting an association with increased complications and in-hospital mortality. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] We aimed to analyse the prognostic value of Tn elevation in patients with IE.…”

Section: Introductionmentioning

confidence: 99%

Cardiac troponin and infective endocarditis prognosis: a systematic review and meta-analysis

Postigo

Vernooij

Fernández‐Avilés

et al. 2021

European Heart Journal. Acute Cardiovascular Care

View full text Add to dashboard Cite

Aims Infective endocarditis (IE) is associated with high mortality and morbidity. Cardiac troponin (Tn) elevation seems to be common in patients with IE and could be associated with a poor prognosis. The aim of this study was to synthesize the prognostic value of Tn in patients with IE. Methods and results We searched in MEDLINE, EMBASE, and the Cochrane library, including the Cochrane Central Register of Controlled Trials (CENTRAL) until February 2020. Observational studies reporting on the association between Tn and in-hospital and 1-year mortality, and IE complications were considered eligible. As each centre uses different conventional or ultra-sensitive Tn, with different normality threshold, we considered them as normal or elevated according to the criteria specified in each article. Articles were systematically selected, assessed for bias, and, when possible, meta-analysed using a random effect model. After retrieving 542 articles, 18 were included for qualitative synthesis and 9 for quantitative meta-analysis. Compared with patients with normal Tn levels, patients with Tn elevation presented higher in-hospital mortality [odds ratio (OR) 5.96, 95% confidence interval (CI) 3.46–10.26; P < 0.0001], 1-year mortality (OR 2.67, 95% CI 1.42–5.02; P = 0.002), and surgery rates (OR 2.34, 95% CI 1.42–3.85; P = 0.0008). They also suffered more frequent complications: central nervous system events (OR 8.85, 95% CI 3.23–24.26; P < 0.0001) and cardiac abscesses (OR 4.96, 95% CI 1.94–12.70; P = 0.0008). Conclusion Tn elevation is associated with a poor prognosis in patients with IE. Troponin determination seems to provide additional help in the prognostic assessment of these patients.

show abstract

“…T.A. Fedorova et al (2016) highlight that the alterations in the myocardium are an essential factor in the development and enhancement of the clinical symptoms of HF and hemodynamic disorders. At the same time, E.M. Idov and I.I.…”

Section: Introductionmentioning

confidence: 99%

The Role of Inflammatory Markers in the Evaluation of Myocardium Alterations, Diagnostics and Prognosis in Patients With Infective Endocarditis

Fedorova¹,

Tazina²,

Semenenko³

et al. 2019

PTQ

View full text Add to dashboard Cite

The results of the examination of 121 patients with infective endocarditis (IE), who received inpatient treatment at the Botkin State Clinical Hospital from 2008 to 2016, were presented in the article. The obtained data on primary and secondary IE with complicated and uncomplicated disease development was analyzed. Diagnostic significance of the dynamic assays of the highly sensitive C-reactive protein (hsСRP), tumor necrosis factor α (TNFα), and highly sensitive troponin I (hsTnI) in the evaluation of the infective toxic process activity, disease severity, and complications were identified. The obtained results indicate the high informative value of the dynamic assay of the levels of TNFα, hsСRP, and hsTnI in patients with IE. The authors established the correlation between the levels of the markers, and the expression of toxic and infectious syndrome manifestations, severity of the disease, and development of complications. A direct correlation was established between the increase in the pro-inflammatory cytokines levels and hsTnI level. It was shown that the increase in troponin concentration corresponded to the expressed morphofunctional alterations in patients with severe HF. Morphological study of the cardiomyocyte destruction revealed the formation of focal dystrophy, development of focal and diffuse fibrosis, indicated on the non-coronarogenic myocardium damage in patients with IE. The myocardium alterations were caused by many factors (hypoxia, microcirculation failure, permeability disorders, etc.), and the cytotoxic effect of pro-inflammatory cytokines, in particular, TNFα, played an essential role in their development. Myocardium alterations, along with the valve destruction, become an important part of the pathogenesis of hemodynamic disorders in patients with IE.

show abstract

Inflammation and cardiac insufficiency associated with infectious endocarditis

Cited by 3 publications

References 1 publication

Infective endocarditis without biological inflammatory syndrome: Description of a particular entity

Infective endocarditis without biological inflammatory syndrome: Description of a particular entity

Cardiac troponin and infective endocarditis prognosis: a systematic review and meta-analysis

The Role of Inflammatory Markers in the Evaluation of Myocardium Alterations, Diagnostics and Prognosis in Patients With Infective Endocarditis

Contact Info

Product

Resources

About