Inflammation and Atherosclerosis

Ley, Klaus

doi:10.3390/cells10051197

Cited by 14 publications

(12 citation statements)

References 11 publications

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“…Atherosclerosis is a chronic disease with an autoimmune component due to its accompaniment with a chronic, lowgrade inflammatory response that attracts cells of the innate and adaptive immune systems into the atherosclerotic plaque (48). The important role of immunity and inflammation in atherosclerosis has been demonstrated by overwhelming experimental and clinical evidence.…”

Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatic Analysis of the Shared Molecular Mechanisms Between Osteoporosis and Atherosclerosis

Liang

Wang

et al. 2022

Front. Endocrinol.

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BackgroundOsteoporosis and atherosclerosis are common in the elderly population, conferring a heavy worldwide burden. Evidence links osteoporosis and atherosclerosis but the exact underlying common mechanism of its occurrence is unclear. The purpose of this study is to further explore the molecular mechanism between osteoporosis and atherosclerosis through integrated bioinformatic analysis.MethodsThe microarray data of osteoporosis and atherosclerosis in the Gene Expression Omnibus (GEO) database were downloaded. The Weighted Gene Co-Expression Network Analysis (WGCNA) and differentially expressed genes (DEGs) analysis were used to identify the co-expression genes related to osteoporosis and atherosclerosis. In addition, the common gene targets of osteoporosis and atherosclerosis were analyzed and screened through three public databases (CTD, DISEASES, and GeneCards). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed by Metascape. Then, the common microRNAs (miRNAs) in osteoporosis and atherosclerosis were screened out from the Human microRNA Disease Database (HMDD) and the target genes of whom were predicted through the miRTarbase. Finally, the common miRNAs–genes network was constructed by Cytoscape software.ResultsThe results of common genes analysis showed that immune and inflammatory response may be a common feature in the pathophysiology of osteoporosis and atherosclerosis. Six hub genes (namely, COL1A1, IBSP, CTSD, RAC2, MAF, and THBS1) were obtained via taking interaction of different analysis results. The miRNAs–genes network showed that has-let-7g might play an important role in the common mechanisms between osteoporosis and atherosclerosis.ConclusionThis study provides new sights into shared molecular mechanisms between osteoporosis and atherosclerosis. These common pathways and hub genes may offer promising clues for further experimental studies.

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Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatic Analysis of the Shared Molecular Mechanisms Between Osteoporosis and Atherosclerosis

Liang

Wang

et al. 2022

Front. Endocrinol.

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“…Chronic inflammation plays a key role in AS progression ( 25 , 26 ). The inflammatory response not only predicts the risk of vascular events but also participates in the pathogenesis of AS-related diseases ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…As we all know, a single circRNA can bind and target multiple miRNAs to play different roles (24), and the pathogenesis of AS is characterized by multiple pathological processes (2,3). Chronic inflammation plays a key role in AS progression (25,26). The inflammatory response not only predicts the risk of vascular events but also participates in the pathogenesis of AS-related diseases (27).…”

Section: Discussionmentioning

confidence: 99%

CircRNA_0050486 promotes cell apoptosis and inflammation by targeting miR-1270 in atherosclerosis

Wang¹,

Bai²,

Mei³

et al. 2022

Ann Transl Med

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Background Atherosclerosis (AS) is a chronic inflammatory disease that plays a major role in cardiovascular disease. Circular RNAs (circRNAs) are related to the pathogenesis of AS, including the inflammatory response. This study aimed to explore the underlying mechanisms of circRNAs and how they regulate the inflammatory response in AS. Methods Analyzed the expression profile of circRNAs in three oxidized low-density lipoprotein (oxLDL) treated macrophage samples and three macrophage control samples using bioinformatics methods. Expression and biological function of circRNA were verified in oxLDL-induced THP-1 macrophages. MiRNAs and target genes of circRNA were predicted by functional enrichment analysis. Expression and function of circRNA target miRNAs were explored in oxLDL-induced THP-1 macrophages. Finally, we predicted and analyzed the function of circRNAs-miRNAs target genes in AS. Results We identified nine upregulated circRNAs and found that circ_0050486 was significantly upregulated in a THP-1 + PMA + oxLDL group compared with a THP-1 + PMA group. Additionally, circ_0050486 knockdown markedly inhibited IL-6 and TNF-α concentrations and the cell death rates in oxLDL-induced THP-1 macrophages. Furthermore, circ_0050486 targeted and inhibited miR-145 and miR-1270 . Upregulated miR-1270 markedly inhibited IL-6 and TNF-α levels and the cell death rates in oxLDL-induced THP-1 macrophages. Finally, the target genes of miR-1270 and miR-145 were predicted by the miRDB, miRWalk, and Targetscan databases, and a functional analysis network of the target genes was constructed by Cytoscape GlueGO, including the regulation of the immune response and monocyte chemotaxis. The common target genes of miR-145 and miR-1270 were established by Cytoscape and included NF1A, among others. Conclusions Our study suggested that circ_0050486 knockdown inhibited inflammation and apoptosis by targeting miR-1270 in oxLDL-induced THP-1 macrophages. This finding may provide a potential therapeutic target for atherosclerosis.

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“…The retention and oxidation of lipoproteins in the intima of arteries has been considered a fundamental event in atherosclerosis. Numerous studies have also shown that low-grade, chronic inflammation of the arterial wall is a component in the development of atherosclerosis [ 3 ]. This process could attract cells of the immune system into the atherosclerotic plaque, and the autoimmune response could switch from a protective to a pathogenic function as atherosclerosis progresses [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Pyroptosis-Related Gene Signature and Expression Patterns in the Deterioration of Atherosclerosis

Ma²,

Wang

et al. 2022

Disease Markers

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Background. Pyroptosis has been shown to be involved in the overall process of atherosclerosis. This study was aimed at investigating pyroptosis-related gene expression patterns in atherosclerosis and their diagnostic significance. Methods and Results. In GSE100927, fifty-four pyroptosis-related genes were identified. Between atherosclerotic plaques and normal samples, the expression patterns of pyroptosis-related genes were significantly different. In order to construct a pyroptosis-related risk score signature (PRSS), the least absolute shrinkage and selection operator (LASSO) was combined with multivariate logistic regression to screen twelve genes. The diagnostic efficiency of the PRSS performed well in GSE43292, as shown by the results of receiver-operating characteristics (ROCs). Consensus clustering identified two expression patterns of pyroptosis-related genes in different statuses of atherosclerotic plaque in GSE163154. The biological behavior of the different clusters was examined by the gene set variation analysis (GSVA). The Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses revealed that the differentially expressed genes (DEGs) in the two clusters were enriched in the immune response. The Cytoscape software was used to construct protein-protein interaction (PPI) networks for hub gene screening. Following that, the Drug Gene Interaction Database (DGIdb) was utilized to find 47 possible medicines and chemical compounds that interact with hub genes in atherosclerotic plaques. Conclusion. The results of this study showed that pyroptosis-related genes contribute to the progression of atherosclerosis and may serve as biomarkers in clinical diagnosis as well as novel therapeutic targets for the treatment of AS.

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Inflammation and Atherosclerosis

Abstract: This 11-chapter Special Issue of Cells spans the gamut from basic science in mechanistic animal models to translational science to outcomes of clinical trials, all focused on the role of inflammation in atherosclerosis [...]

Cited by 14 publications

References 11 publications

Integrated Bioinformatic Analysis of the Shared Molecular Mechanisms Between Osteoporosis and Atherosclerosis

Integrated Bioinformatic Analysis of the Shared Molecular Mechanisms Between Osteoporosis and Atherosclerosis

CircRNA_0050486 promotes cell apoptosis and inflammation by targeting miR-1270 in atherosclerosis

Pyroptosis-Related Gene Signature and Expression Patterns in the Deterioration of Atherosclerosis

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