Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases

Brahadeeswaran, Subhashini; Sivagurunathan, Narmadhaa; Latchoumycandane, Calivarathan

doi:10.1007/s12035-021-02683-5

Cited by 29 publications

(23 citation statements)

References 130 publications

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“…IL-1β has been reported to induce both TNF-α and IL-1β expression in MG, both contribute to MG inflammation ( Giblin et al, 2021 ). IL-18 is another member of the IL-1 family expressed by MG ( Zhang et al, 2022 ), well known for its pro-inflammation functions ( Kaplanski, 2018 ), and is found to participate in age-related neurodegenerative diseases with IL-1β ( Brahadeeswaran et al, 2022 ). Being one of the IL-1 family, IL-33 is also shown to be mainly expressed by MG in the neural retina, which is elevated in AMD patients and regulates mononuclear phagocyte recruitment to the photoreceptor layer by increasing inflammatory chemokine and cytokine expression ( Xi et al, 2016 ).…”

Section: Cytokines and The Mgmentioning

confidence: 99%

Regulations of Retinal Inflammation: Focusing on Müller Glia

Chen

Xia

Zeng

et al. 2022

Front. Cell Dev. Biol.

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Retinal inflammation underlies multiple prevalent retinal diseases. While microglia are one of the most studied cell types regarding retinal inflammation, growing evidence shows that Müller glia play critical roles in the regulation of retinal inflammation. Müller glia express various receptors for cytokines and release cytokines to regulate inflammation. Müller glia are part of the blood-retinal barrier and interact with microglia in the inflammatory responses. The unique metabolic features of Müller glia in the retina makes them vital for retinal homeostasis maintenance, regulating retinal inflammation by lipid metabolism, purine metabolism, iron metabolism, trophic factors, and antioxidants. miRNAs in Müller glia regulate inflammatory responses via different mechanisms and potentially regulate retinal regeneration. Novel therapies are explored targeting Müller glia for inflammatory retinal diseases treatment. Here we review new findings regarding the roles of Müller glia in retinal inflammation and discuss the related novel therapies for retinal diseases.

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Section: Cytokines and The Mgmentioning

confidence: 99%

Regulations of Retinal Inflammation: Focusing on Müller Glia

Chen

Xia

Zeng

et al. 2022

Front. Cell Dev. Biol.

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“…Increasing evidence suggests that excessive inflammation plays a crucial role in the onset and progression of stress-related diseases. Evidence supports the idea that the inflammatory response forms the background of multifactorial diseases, including psychiatric disorders [ 13 , 87 , 88 , 89 , 90 ].…”

Section: Stress Inflammation and Depressionmentioning

confidence: 67%

The Relationship between Stress, Inflammation, and Depression

2022

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A narrative review about the relationship between stress, inflammation, and depression is made as follows: Chronic stress leads to various stress-related diseases such as depression. Although most human diseases are related to stress exposure, the common pathways between stress and pathophysiological processes of different disorders are still debatable. Chronic inflammation is a crucial component of chronic diseases, including depression. Both experimental and clinical studies have demonstrated that an increase in the levels of pro-inflammatory cytokines and stress hormones, such as glucocorticoids, substantially contributes to the behavioral alterations associated with depression. Evidence suggests that inflammation plays a key role in the pathology of stress-related diseases; however, this link has not yet been completely explored. In this study, we aimed to determine the role of inflammation in stress-induced diseases and whether a common pathway for depression exists. Recent studies support pharmacological and non-pharmacological treatment approaches significantly associated with ameliorating depression-related inflammation. In addition, major depression can be associated with an activated immune system, whereas antidepressants can exert immunomodulatory effects. Moreover, non-pharmacological treatments for major depression (i.e., exercise) may be mediated by anti-inflammatory actions. This narrative review highlights the mechanisms underlying inflammation and provides new insights into the prevention and treatment of stress-related diseases, particularly depression.

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“…Although our study did not investigate frailty evolution over time during the spa therapy period, it is possible to think that the anti-inflammatory effects of spa treatments (12,13) could reduce frailty severity. As one of the basic mechanisms leading to aging (22), low grade chronic inflammation is involved in the onset and severity of a myriad of age-related conditions (23)(24)(25)(26), being an important biological substrate favoring the phenotypic expression of frailty (27,28). Future investigations, in particular a randomized controlled trial, should examine the effects of spa therapy on frailty severity as well as on other health outcomes (eg, mobility, nutritional status, cognitive function, falls, hospital and nursing home admissions) in frail people.…”

Section: Discussionmentioning

confidence: 99%

Identifying Frailty in Thermal/Spa Clinical Setting: A Cross-Sectional Study

Jeandel¹,

Hanh²

2022

J Aging Res & Lifestyle

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Background: No investigation has assessed frailty in the clinical setting of thermal/spa facilities, which often receive older patients with osteo-articular and musculoskeletal conditions. Objective: To examine the prevalence of frailty in older adults receiving thermal/spa treatment and to gather preliminary evidence about the feasibility of integrating geriatric assessments, including frailty, in the routine clinical consultations in spa facilities. Methods: Mixed design, with a quantitative cross-sectional investigation performed among 197 volunteer patients (mean age 73.2 ± 6.4 years-old; 82.2% women) of seven French thermal/spa facilities and a qualitative investigation (semi-structured interviews) with the nine physicians working in the participating facilities. Frailty was defined according to a modified Fried frailty phenotype based on six self-reported criteria (including mobility impairment, nutritional status, and fatigue): individuals meeting ≥3 criteria were considered frail; 1-2 criteria, pre-frail; no criterion, robust. Interviews with the participating physicians on the feasibility of integrating geriatric assessments in routine clinical consultations at spa facilities were recorded and their content, analyzed. Results: Frailty was detected in 112 individuals (56.9%), 26 (13.2%) were considered prefrail, and 59 (29.9%), robust. Regarding the interviews, three physicians indicated the geriatric assessments could be integrated in the routine spa consultations; two, in the consultations of specific/targeted patients, but not in routine; two, only in the context of health education; two, in the context of research protocols. The content of interviews highlighted geriatric assessments provided a better overview of the health/clinical status of the patients. Conclusion: Frailty is very prevalent in older patients of spa facilities. Such facilities may constitute an interesting clinical setting for screening for frailty through the implementation of geriatric assessments.

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Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases

Cited by 29 publications

References 130 publications

Regulations of Retinal Inflammation: Focusing on Müller Glia

Regulations of Retinal Inflammation: Focusing on Müller Glia

The Relationship between Stress, Inflammation, and Depression

Identifying Frailty in Thermal/Spa Clinical Setting: A Cross-Sectional Study

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