2020
DOI: 10.3389/fcimb.2020.00489
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Inflammasome Fuels Dengue Severity

Abstract: Dengue is an acute febrile disease triggered by dengue virus. Dengue is the widespread and rapidly transmitted mosquito-borne viral disease of humans. Diverse symptoms and diseases due to Dengue virus (DENV) infection ranges from dengue fever, dengue hemorrhagic fever (life-threatening) and dengue shock syndrome characterized by shock, endothelial dysfunction and vascular leakage. Several studies have linked the severity of dengue with the induction of inflammasome. DENV activates the NLRP3-specific inflammaso… Show more

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Cited by 33 publications
(40 citation statements)
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“…Inflammasomes, cellular molecular sensors for PAMPs and DAMPs, are multimeric protein complexes comprising of NLRs [nucleotide-binding domain (NBD) and leucine-rich-repeat-(LRR)-containing], the absent in melanoma-2 (AIM2)-like receptors (ALRs), an adaptor molecule ASC (apoptosis-associated speck-like protein containing a CARD), and procaspase-1 ( 14 , 25 , 69 , 70 ). Activation of inflammasomes leads to protein-cleavage processes, turning pro-caspase 1 into active form caspase 1, which converts pro-IL-1β and pro-IL-18 into respective active forms (IL-1β and IL-18) ( 69 ).…”
Section: Discussionmentioning
confidence: 99%
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“…Inflammasomes, cellular molecular sensors for PAMPs and DAMPs, are multimeric protein complexes comprising of NLRs [nucleotide-binding domain (NBD) and leucine-rich-repeat-(LRR)-containing], the absent in melanoma-2 (AIM2)-like receptors (ALRs), an adaptor molecule ASC (apoptosis-associated speck-like protein containing a CARD), and procaspase-1 ( 14 , 25 , 69 , 70 ). Activation of inflammasomes leads to protein-cleavage processes, turning pro-caspase 1 into active form caspase 1, which converts pro-IL-1β and pro-IL-18 into respective active forms (IL-1β and IL-18) ( 69 ).…”
Section: Discussionmentioning
confidence: 99%
“…In addition to EIII, DENV membrane protein (M) and non-structural proteins NS2A, NS2B were also shown to induce inflammasome activation ( 14 , 97 , 98 ), and NS1 was demonstrated to enhance inflammation through a toll-like receptor 4 ( 99 , 100 ). NS2A, NS2B have shown to serve as viroporins to increase cell-membrane permeability and activate inflammasome ( 14 , 101 , 102 ).…”
Section: Discussionmentioning
confidence: 99%
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