Inflamación sistémica de grado bajo y su relación con el desarrollo de enfermedades metabólicas: de la evidencia molecular a la aplicación clínica

León-Pedroza, José Israel; González-Tapia, Luis Alonso; Olmo-Gil, Esteban del; Castellanos-Rodríguez, Diana; Escobedo, Galileo; González-Chávez, Antonio

doi:10.1016/j.circir.2015.05.041

Cited by 49 publications

(25 citation statements)

References 44 publications

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“…Es importante señalar que estos cambios mencionados en la actividad física y alimentación generan un perfil doblemente riesgoso en la acumulación excesiva de tejido adiposo, modificando su función y provocando inflamación sistemática local o de bajo grado que, a su vez, se asocia con el desarrollo de enfermedades cardiometabólicas 26,27 . Un estudio experimental indicó que una intervención nutricional previa a las VFP en estudiantes universitarios chilenos no es suficiente para garantizar cambios en los hábitos alimentarios y en los niveles de actividad física 9 , a diferencia de la población escolar 10 , siendo la población universitaria más resistente a cambios beneficiosos para su salud durante las VFP.…”

Section: Discussionunclassified

¿Cuánto cambia la composición corporal después de las vacaciones de fiestas patrias en estudiantes universitarios con sobrepeso y obesidad?

et al. 2021

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Objetivo: Describir la variación en diversos indicadores de la composición corporal antes y después de vacaciones de fiestas patrias (VFP) en estudiantes universitarios con sobrepeso y obesidad. Métodos: Se evaluó la composición corporal a 11 estudiantes, dos veces antes (t1 y t2) y una vez posterior a VFP (t3). Se midió el peso, cintura, cadera, se calculó el índice de masa corporal (IMC) y se evaluó la masa grasa y magra segmental a través de absorciometría dual de rayos X (DEXA). Una ANOVA de medidas repetidas se utilizó para detectar cambios entre los tiempos (t1, t2 y t3). Resultados:Previo a VFP (t1-t2) se observa una disminución en la razón cintura/cadera (-4.26%; p=0.024). Posterior a las VFP (t2-t3) se aprecia un aumento significativo de la masa grasa total (+428g, p=0.019) y también una disminución en el índice musculoesquelético relativo (IMSR; -1.35%; p=0.048). No se observan cambios en indicadores antropométricos como peso e IMC. Conclusión: Las VFP se asocian a una variación desfavorable de la composición corporal en estudiantes universitarios con sobrepeso y obesidad. Considerar el peso corporal o IMC podría subvalorar el real impacto de este periodo crítico sobre la composición corporal de personas que presentan malnutrición por exceso.

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Section: Discussionunclassified

¿Cuánto cambia la composición corporal después de las vacaciones de fiestas patrias en estudiantes universitarios con sobrepeso y obesidad?

et al. 2021

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“…All these factors yield an excessive volume of adipose tissue, modifying the function and number of adipose cells. This response of the organism causes a local or low-grade systemic inflammation [ 40 ], which, in turn, is correlated with the development of cardio-metabolic diseases [ 41 ] and cancers [ 40 ]. Therefore, it is recommendable that critical periods should be taken into account in the public health system as a potential hazard to populations health, because the sum of short critical periods during a year could affect people’s health in the future.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Single Nutritional Intervention Previous to a Critical Period of Fat Gain in University Students with Overweight and Obesity: A Randomized Controlled Trial

Hernández-Jaña

Huber-Pérez

Palma-Leal

et al. 2020

IJERPH

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Background: the present study aimed to investigate the effects of a single nutritional preventive session previous to a critical period linked to fat gain in university students with overweightness and obesity, emulating a nutritional session of a public health system. Methods: In this single-blind randomized controlled trial, 23 students met all the criteria to be included (20.91 ± 2.52-year-old; 52.2% women) who were divided into two groups: intervention group (IG) and control group (CG). Fat mass (FM) by dual-energy X-ray absorptiometry (DXA), physical activity by accelerometry, feeding evaluation through three questionnaires, and a set of healthy lifestyle recommendations were evaluated before and after the national holidays (NH). Results: Our findings showed that FM increased significantly in the CG, but not in the IG (CG = 428.1g; IG = 321.9g; D = 106.2g; p = 0.654 [95% CI = −379.57, 591.92]). However, no differences were found during the NH between them (Hedges’ g effect size = 0.19; p = 0.654). In addition, no statistical differences were observed between groups in feeding evaluations, the set of recommendations performed, and physical activity. Conclusion: a single preventive session before a critical period, using a similar counselling approach as used in the public health system, might not be enough to promote changes in eating and physical activity patterns and preventing fat gain in overweight/obese university students. Long-term interventions are a must.

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“…Systemic inflammation is characterized by high circulating levels of active inflammatory cytokines, including C-reactive proteins, tumor necrosis factor-α (TNF-α) and interleukins (IL) 1β and 6, in addition to an increase in immune cell infiltration. [ 21 ] Increasing inflammatory cytokines and the resulting systemic inflammation affect unfavorable biomarkers of dementia by increasing burdens of Aβ-peptide and tau protein, and decreasing hippocampal volumes. [ 22 ]…”

Section: Discussionmentioning

confidence: 99%

Peptic ulcer does not increase the risk of dementia

Choi¹,

Soh²,

Lim

et al. 2020

Medicine

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Studies have shown that peptic ulcer disease (PUD) increases the risk of dementia via the mechanism of systemic inflammation. We examined the association between PUD and the risk of dementia using a population-based national sample cohort from South Korea. Using the national cohort study from the Korean National Health Insurance Service, we extracted data for patients with dementia (n = 11,434) and for 1:4 matched control participants (n = 45,736) and then analyzed the previous histories of PUD from 2002 to 2013 using conditional logistic regression analyses. The controls were matched to the patients according to age, sex, income, region of residence, and past medical history. Subgroup analyses were performed based on age and sex. There was no statistically significant difference in the incidence of PUD between the dementia and control groups (18.0% vs 17.4%, P = .107). The adjusted odds ratio (OR) for PUD was 0.92 (95% confidence interval [CI] = 0.88–0.97, P = .002). In the subgroup analysis based on age, the adjusted ORs for PUD were 0.93 (95% CI = 0.88–0.99) in the <80-year-old group and 0.90 (95% CI = 0.82–1.00) in the ≥80-year-old group (each P < .05). In the subgroup analysis based on sex, the adjusted ORs for PUD were 0.89 (95% CI = 0.81–0.97; P < .05) in men and 0.94 (95% CI = 0.89–1.00; P = .06) in women. PUD does not increase the risk of dementia at any age or in either sex after adjusting for age and the history of hypertension, diabetes mellitus, dyslipidemia, ischemic heart disease, stroke, and depression.

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Inflamación sistémica de grado bajo y su relación con el desarrollo de enfermedades metabólicas: de la evidencia molecular a la aplicación clínica

Cited by 49 publications

References 44 publications

¿Cuánto cambia la composición corporal después de las vacaciones de fiestas patrias en estudiantes universitarios con sobrepeso y obesidad?

¿Cuánto cambia la composición corporal después de las vacaciones de fiestas patrias en estudiantes universitarios con sobrepeso y obesidad?

Effect of a Single Nutritional Intervention Previous to a Critical Period of Fat Gain in University Students with Overweight and Obesity: A Randomized Controlled Trial

Peptic ulcer does not increase the risk of dementia

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