Inflamação: entre a regeneração e a cicatrização

Ruh, Anelice Calixto; Fernandes, Daniel; Artoni, Roberto Ferreira; Fávero, Giovani Marino

doi:10.5212/publ.biologicas.v.19i1.0002

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…It is characterized by the migration of keratinocytes and epithelial cells from the wound margins toward the center and the subsequent formation of skin appendages [ 37 , 39 ]. Keratinocytes stimulated by keratinocyte growth factor (KGF) [ 40 , 41 ] repair the epithelial layer [ 36 , 42 ]. Taken together, our findings suggest that DPG may positively influence cell proliferation and migration in the dermis and epidermis, and, thus, the scar.…”

Section: Resultsmentioning

confidence: 99%

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

Leite

Bonafé

Pires

et al. 2023

IJMS

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Wound healing is characterized by a systemic and complex process of cellular and molecular activities. Dipotassium Glycyrrhizinate (DPG), a side product derived from glycyrrhizic acid, has several biological effects, such as being antiallergic, antioxidant, antibacterial, antiviral, gastroprotective, antitumoral, and anti-inflammatory. This study aimed to evaluate the anti-inflammatory effect of topical DPG on the healing of cutaneous wounds by secondary intention in an in vivo experimental model. Twenty-four male Wistar rats were used in the experiment, and were randomly divided into six groups of four. Circular excisions were performed and topically treated for 14 days after wound induction. Macroscopic and histopathological analyses were performed. Gene expression was evaluated by real-time qPCR. Our results showed that treatment with DPG caused a decrease in the inflammatory exudate as well as an absence of active hyperemia. Increases in granulation tissue, tissue reepithelization, and total collagen were also observed. Furthermore, DPG treatment reduced the expression of pro-inflammatory cytokines (Tnf-α, Cox-2, Il-8, Irak-2, Nf-kB, and Il-1) while increasing the expression of Il-10, demonstrating anti-inflammatory effects across all three treatment periods. Based on our results, we conclude that DPG attenuates the inflammatory process by promoting skin wound healing through the modulation of distinct mechanisms and signaling pathways, including anti-inflammatory ones. This involves modulation of the expression of pro- and anti-inflammatory cytokine expression; promotion of new granulation tissue; angiogenesis; and tissue re-epithelialization, all of which contribute to tissue remodeling.

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Section: Resultsmentioning

confidence: 99%

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

Leite

Bonafé

Pires

et al. 2023

IJMS

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“…Following injury, various intracellular and intercellular pathways are activated to restore tissue integrity and homeostasis. The cellular components of the immune system (neutrophils, monocytes, lymphocytes, and dendritic cells), the flux of coagulation, and mobilized inflammatory pathways lead to cell differentiation, proliferation, and migration during tissue repair, and this activation occurs via a variety of inflammatory mediators [ 29 ]. Inflammation as a subclinical condition is mediated in part by pro-inflammatory cytokines and oxidative stress (mainly by reactive oxygen species-ROS).…”

Section: Introductionmentioning

confidence: 99%

Hyperinflammatory Response in COVID-19: A Systematic Review

Silva

Ribeiro

Gouveia

et al. 2023

Viruses

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COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory response that cause systemic inflammation are extremely linked to its severity. This research sought to review the immunopathological elements that contribute to its progression. This is a systematic review using the PUBMED, LILACS, MEDLINE, and SCIELO databases using articles between May 2020 and July 2022 with the following search terms in conjunction with “AND”: “SARS-CoV-2”; “COVID-19”; “ARDS” and “Cytokine Storm”. The quality appraisal and risk of bias were assessed by the JBI checklists and the Cochrane Collaboration’s RoB 2.0 and ROBINS-I tools, respectively, and the risk of bias for in vitro studies by a pre-defined standard in the literature. The search resulted in 39 articles. The main actors in this response denote SARS-CoV-2 Spike proteins, cellular proteases, leukocytes, cytokines, and proteolytic cascades. The “cytokine storm” itself brings several complications to the host through cytokines such as IL-6 and chemokines (such as CCL2), which influence tissue inflammation through apoptosis and pyroptosis. The hyperinflammatory response causes several unfavorable outcomes in patients, and systemic inflammation caused largely by the dysregulation of the immune response should be controlled for their recovery.

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“…Healing is a tissue repair process that occurs after an injury, begins after the injury and has as purpose the formation of new tissue which is divided into three subsequent phases that are juxtaposed: inflammation, formation of granulation tissue and deposition of extracellular matrix, and remodeling (Mendonça and Coutinho-Netto, 2009;Isaac et al, 2010;Ruh et al, 2013). Over the years it has deserved researchers' attention, mainly in relation to the factors that delay or difficult its mechanisms .…”

Section: Introductionmentioning

confidence: 99%

Healing effect of the microemulsion enriched with hydroalcoholic extract of Abarema cochliacarpa (Gomes) Barneby J. W. Grimes (Fabaceae)

Dias¹,

Andrade²,

Santos³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Abarema cochliocarpa is an endemic plant of Brazil and has been traditionally used as a popular medicine to treat various diseases and mostly as a healing agent. The aim of this study was to evaluate the healing effect of the microemulsion containing hydrometanic fraction of the inner bark (HMF) of the plant, as well as its antioxidant, antitumor and cytotoxic potential. The cytotoxicity of HMF was assessed by the viability of J774 macrophages cells and the antiproliferative activity in lines of human tumor cells. The antioxidant capacity of the formulation was evaluated in vitro by the ability to scavenge the DPPH and the healing effect was evaluated in Rattus novergicus in 7, 14, 21 days. The HMF significantly favored the viability of J774 macrophages in all tested concentrations and it was dosedependent. The antiproliferative potential of FHM against human tumor cells was not satisfactory. This formulation presented CE 50 of 24.87 ± 0.62 µg.mL -1 , and healing effect of 55.18 and 100% of wound retraction up to the 7th and 21 st days of treatment, respectively. The bioactive compound of HMF isolated by HPLC was identified by 1 H and 13 C NMR and by literature data as (+)-catechin. The formulation has curative effect. It can be concluded that the phenolic compounds act in the reduction of oxidative stress and contribute to faster healing.

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Inflamação: entre a regeneração e a cicatrização

Cited by 3 publications

References 14 publications

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

Hyperinflammatory Response in COVID-19: A Systematic Review

Healing effect of the microemulsion enriched with hydroalcoholic extract of Abarema cochliacarpa (Gomes) Barneby J. W. Grimes (Fabaceae)

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