“…[2][3][4] Therefore, occlusion may not be necessary for all patients with patent foramen ovale or atrial septal defect, as some may suffer from its complications, including peripheral embolism, thrombosis, and arterial hypertension. 5,6 Moreover, if the patients are troubled with coronary artery disease, arrhythmia, or diabetes, the patent foramen ovale or atrial septal defect may lead to a higher incidence of major cardiovascular complications. Patients are only considered to receive an intervention in cases of cryptogenic stroke or thrombotic attacks.…”