Infiltrative optic neuropathy as a relapse of acute lymphoblastic leukemia

Rachwani-Anil, Rahul; Rocha‐de‐Lossada, Carlos; Martín, F. del Castillo; Ortega, A Santos; Aranda, G. Luque; Contreras, M. España; Gomez, Jorge

doi:10.1016/j.jfo.2020.03.008

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Infiltrative processes of the optic nerve likewise generate RGC degeneration. An example is the leukemic optic neuropathy, mainly associated with acute lymphoblastic leukemia [544][545][546]. The involvement of the optic nerve in leukemic cases remains, however, a rare circumstance, which may mostly appear in relapses and late in the disease course [547,548].…”

Section: Infiltrative Optic Neuropathiesmentioning

confidence: 99%

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Buonfiglio,

Böhm,

Pfeiffer

et al. 2023

Antioxidants

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Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an imbalance in the redox status characterized by an excess of reactive oxygen species (ROS), in driving cell death through apoptosis, autophagy, and inflammation. This review provides an overview of ROS-related processes underlying four extensively studied optic nerve diseases: glaucoma, Leber’s hereditary optic neuropathy (LHON), anterior ischemic optic neuropathy (AION), and optic neuritis (ON). Furthermore, we present preclinical findings on antioxidants, with the objective of evaluating the potential therapeutic benefits of targeting oxidative stress in the treatment of optic neuropathies.

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Section: Infiltrative Optic Neuropathiesmentioning

confidence: 99%

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Buonfiglio,

Böhm,

Pfeiffer

et al. 2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Infiltrative processes of the optic nerve likewise generate RGC degeneration. An example is the leukemic optic neuropathy, mainly associated with acute lymphoblastic leukemia [541][542][543]. Involvement of the optic nerve in leukemic cases remains anyway a rare circumstance, which may mostly appear in relapses and late in the disease course [544,545].…”

Section: Infiltrative Optic Neuropathiesmentioning

confidence: 99%

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Buonfiglio,

Böhm,

Pfeiffer

et al. 2023

Preprint

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Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an imbalance in the redox status characterized by an excess of reactive oxygen species (ROS), in driving cell death through apoptosis, autophagy, and inflammation. This review provides an overview of ROS-related processes underlying four extensively studied optic nerve diseases: glaucoma, Leber's hereditary optic neuropathy (LHON), anterior ischemic optic neuropathy (AION), and optic neuritis (ON). Furthermore, we present preclinical findings on antioxidants, with the objective of evaluating the potential therapeutic benefits of targeting oxidative stress in the treatment of optic neuropathies.

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Acute lymphoblastic leukemia relapse presenting with optic nerve infiltration

Dini

Capolsini

Cerri

et al. 2023

SAGE Open Medical Case Reports

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Acute lymphoblastic leukemia is the most common childhood malignancy. Despite many advances in therapy, about 15%–20% of children with acute lymphoblastic leukemia experience a disease relapse. Isolated ocular relapse is relatively rare. A 14-year-old male with T-cell acute lymphoblastic leukemia in remission presented with sudden onset of right eye pain and visual acuity impairment. Fundoscopic examination of the eye and magnetic resonance imaging of the orbits were consistent with optic nerve infiltration. The patient was treated with salvage chemotherapy, orbital radiation and eventual bone marrow transplantation, with notable improvement in vision and regression of retinal and optic nerve findings. Optic nerve infiltration represents an ophthalmic emergency and requires urgent management. The use of radiation therapy is a helpful adjunct with systemic chemotherapy in obtaining disease remission.

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Infiltrative optic neuropathy as a relapse of acute lymphoblastic leukemia

Cited by 3 publications

References 7 publications

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Acute lymphoblastic leukemia relapse presenting with optic nerve infiltration

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