Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma

Li, Chunnan; Shintani, Satoru; Terakado, Nagaaki; Nakashiro, Koh‐ichi; Hamakawa, Hiroyuki

doi:10.3892/or.9.6.1219

Cited by 55 publications

(70 citation statements)

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“…Accumulation of TAMs in the cancer stroma is correlated with angiogenesis in various cancers (33)(34)(35)(36)(37), including oral cancer. TAMs also increase the secretion of angiogenic factors such as vascular endothelial growth factor and contribute to the integrity of the vascular structure of OSCC (8,38). However, contradictory data has also been reported indicating a lack of correlation between TAM distribution and angiogenic activity (39).…”

Section: Discussionmentioning

confidence: 92%

“…Tumor-associated macrophages (TAMs) have various effects on tumor growth (5)(6)(7)(8). Although the existence of TAMs in the metastatic region has been recognized, the role of these cells has only recently been appreciated.…”

Section: Introductionmentioning

confidence: 99%

“…Although the expression of MMPs and distribution of TAMs in OSCC have been intensely studied (8,10,11), a comparison of the expression levels and distribution patterns in the primary and metastatic regions has not been well defined. Research in these fields will help provide insight into the clinical behavior of OSCC.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of MMP2 and MMP9 expression levels between primary and metastatic regions of oral squamous cell carcinoma

et al. 2016

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Matrix metalloproteinases (MMPs)and tumor-associated macrophages (TAMs) play important roles in tumor growth. The present study investigated the expression levels of MMP2 and MMP9 in relation to the distribution of TAMs in the primary and metastatic regions of oral squamous cell carcinoma. Twenty-nine cases of oral squamous cell carcinoma (OSCC) with regional lymph node metastasis were selected from available documents in the archives of the Department of Pathology, Nihon University School of Dentistry. Four-micrometerthick sections were prepared from the primary and metastatic regions. Each section was subjected to immunohistochemical staining using anti-MMP2, anti-MMP9, and anti-CD68 antibodies. The distribution and localization of MMPs and TAMs were compared between primary and metastatic regions. The expression levels of both MMPs were higher in the metastatic regions of lingual and gingival cancers. Statistically significant differences were observed in both T1 and T2 cases. In contrast to the higher expression of MMPs in metastatic regions, a higher number of TAMs were distributed in the primary regions. From these results, MMP expression levels and the numbers of TAMs were expected to have an inverse relationship between the primary and metastatic regions of OSCC. (J Oral Sci 58, 59-65, 2016)

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Comparison of MMP2 and MMP9 expression levels between primary and metastatic regions of oral squamous cell carcinoma

et al. 2016

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“…Furthermore, Leek and colleagues and others reported that the number of macrophages infiltrated into tumors correlated with capillary density and a poor prognosis (23,24). However, the relationship between Flt-1 signaling and tumor progression in s.c. tissue has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

Vascular Endothelial Growth Factor Receptor-1 Signaling Promotes Mobilization of Macrophage Lineage Cells from Bone Marrow and Stimulates Solid Tumor Growth

et al. 2010

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Vascular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis under physiologic and pathologic conditions. Recently, Flt-1-expressing cells were reported to contribute to the intracranial growth of glioma cells. However, the role of Flt-1 signaling in solid tumor growth in s.c. tissue has not been elucidated. To investigate how Flt-1 signaling is involved in the proliferation of solid tumors, we implanted tumor cells into wild-type (

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“…Tumor associated macrophages (TAMs) are typically type II cells reported to promote growth of various tumors including breast, prostate and lung [31]. CD68 stained TAMs are present at higher levels in HNSCC and modulate angiogenesis during tumor progression [32,33]. Primary HNSCC tumor with high TAM infiltration is a strong predictor of lymph node metastasis, extracellular capsular spread and advanced HNSCC stage [34].…”

Section: Tumor Associated Macrophagesmentioning

confidence: 99%

The Cellular Microenvironment of Head and Neck Squamous Cell Carcinoma

Mathew¹,

Thomas²

2012

Squamous Cell Carcinoma

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Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma

Cited by 55 publications

References 0 publications

Comparison of MMP2 and MMP9 expression levels between primary and metastatic regions of oral squamous cell carcinoma

Comparison of MMP2 and MMP9 expression levels between primary and metastatic regions of oral squamous cell carcinoma

Vascular Endothelial Growth Factor Receptor-1 Signaling Promotes Mobilization of Macrophage Lineage Cells from Bone Marrow and Stimulates Solid Tumor Growth

The Cellular Microenvironment of Head and Neck Squamous Cell Carcinoma

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