Infiltration of cervical lymph nodes by B‐ and T‐cell non‐Hodgkin's lymphoma and Hodgkin's lymphoma: Preliminary ultrasonic findings

Abstract

Ultrasonography has been used in the evaluation of enlarged lymph nodes in patients with malignant lymphoma, which comprises a variety of histopathological subtypes. We assessed ultrasonic findings of infiltration in cervical lymph nodes of 47 patients with previously untreated malignant lymphoma and correlated them with histopathological subtypes. Common findings among various histopathological subtypes were hypoechoic masses, spot and/or line echoes, involvement of multiple nodes, and posterior enhancement. In addition, each histopathological subtype showed characteristic findings: Hodgkin's disease had a contour with a lobular pattern (9/10 cases), septum-like echo (9/10 cases), and tubular structure (9/10 cases) in the internal echo, reflecting histopathologically fibrous connective tissue surrounding lymph nodes and small vessels. In B-cell lymphoma, there was characteristically a tendency for lymph node fusion (19/28 cases) and spot and/or line echoes (17/28 cases), reflecting histopathological replacement and destruction of the structure of lymph node and capsule by proliferation of lymphocytes. These findings were strengthened in diffuse large B-cell lymphoma. T-cell lymphoma was distinguished from other types of lymphoma by the presence of a hilum-like echo (6/9 cases), reflecting histopathologically prominent vascularization in lymph nodes accompanied by a dilated hilum area. In summary, this preliminary study suggests that ultrasonic findings of infiltration of cervical lymph nodes in major subtypes of malignant lymphoma could reflect characteristic histopathological structures, therefore providing information helpful for differentiating them. Am. J. Hematol. 67:234-239, 2001.

Frequency of Hodgkin's Lymphoma in Patient With Cervical Lymphadenopathy Presenting in a Public Sector Hospital in Pakistan

“…It is very much comparable to other studies, Stark GL observed 36% in early stage, 64% in advance diseases while Hong et al, analyzed 34 patient of Hodgkin's lymphoma in Taiwan in 1992, revealing extremely high incidence (80.6%) of advance clinical stage (III and IV) 12,13 . In our study mixed cellularity was most common (45%) where as in other studies nodular sclerosis was more common (44-69%) 3,12,14 .…”

Sonographic Evaluation of the Treatment Response in Patients With Immunoglobulin G4–Related Disease of the Submandibular Glands

“…Sonography is used to evaluate various diseases of superficial organs of the craniocervical region, such as the submandibular glands and organs involving regional lymphadenopathy 4 – 8 . This modality is noninvasive, inexpensive, and efficient in assessing these diseases as the initial examination of choice.…”

Localized or Diffuse Lesions of the Submandibular Glands in Immunoglobulin G4-Related Disease in Association With Differential Organ Involvement

“…Sonography has been used for evaluation of diseases of the submandibular glands and regional lymphadenopathy 13 – 17 . It is a noninvasive, inexpensive, and efficient examination to evaluate these diseases as an initial investigation of choice.…”