Infiltration of cervical cancer tissue with human papilloma virus-specific cytotoxic T-lymphocytes

Dendritic cell-based tumor vaccine for cervical cancer I: in vitro stimulation with recombinant protein-pulsed dendritic cells induces specific T cells to HPV16 E7 or HPV18 E7

“…The presence of HPV16 E7-specific CTLs in tumor and draining lymph nodes of cervical cancer patients has been detected in previous studies (Evans et al 1997). Obviously, T cells are capable of homing to the HPV-transformed epithelial tissue or tumor and can be isolated from such sites.…”

Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model

“…It has been suggested that initial cervical lesions are infiltrated by IgG-producing B cells, suggesting that the antibody response plays an important role in early cervical neoplasia [23]. On the other hand, HPV-specific T cells might be involved in restricting disease progression [24]. However, like most human cancers, HPV-associated neoplasia can avoid immune attacks by transforming the genome and by down-regulating the functions of effector cells, such as cytotoxic T cells, tumor-infiltrating lymphocytes, and dendritic cells [25,26].…”

Immunity to Sexually Transmitted Infections

“…Local CTL responses in cervical cancer tissues, draining lymph nodes, and peripheral blood have been examined in a few patients (Evans et al, 1997): E7 peptide-specific CTLs were detected in the peripheral blood of four of five patients, in draining lymph nodes (three of four patients), and in only one of three cervical cancer tissues. Obviously, additional studies are required to determine the importance of local CMI responses in the clearance of HPV from infected keratinocytes.…”