Infiltration of CD3+ and CD8+ lymphocytes in association with inflammation and survival in pancreatic cancer
Gerik W. Tushoski-Alemán,
Kelly M. Herremans,
Patrick W. Underwood
et al.
Abstract:Background
Pancreatic ductal adenocarcinomas (PDAC) have heterogeneous tumor microenvironments relatively devoid of infiltrating immune cells. We aimed to quantitatively assess infiltrating CD3+ and CD8+ lymphocytes in a treatment-naïve patient cohort and assess associations with overall survival and microenvironment inflammatory proteins.
Methods
Tissue microarrays were immunohistochemically stained for CD3+ and CD8+ lymphocytes and quantitatively assessed using QuPath. Levels of inflammation-associated pro… Show more
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