Infiltration and local differentiation of bone marrow–derived integrinβ7-positive mast cell progenitors in atopic dermatitis–like skin

Keith, Yuki Honda; Honda, Tetsuya; Ono, Sachiko; Lee, Bernett; Shibuya, Rintaro; Hanakawa, Sho; Ishida, Yoshihiro; Nakamizo, Satoshi; Kabashima, Kenji

doi:10.1016/j.jaci.2022.09.011

Cited by 9 publications

(11 citation statements)

References 45 publications

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“…Bertolini et al proposed that the increased number of MCs in AA results from enhanced local proliferation of MCs and increased recruitment of progenitor MCs from the circulation [ 33 ]. This hypothesis is supported by Keith and colleagues, who distinguished bone-marrow-derived MC (BMMCs) from resident MCs on the basis of integrin-β7 expression in murine models of AD [ 34 , 35 ]. In psoriasis, activated MCs expressing IL-17, TNF-α, and IL-22 are consistently found enriched in involved and uninvolved skin compared with normal skin [ 36 ].…”

Section: Mast Cells and Cd8 T Cells In Tissue Homeostasis And Diseasementioning

confidence: 98%

Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

Chen

Griffiths

Bulfone–Paus∥

2023

IJMS

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The skin is exposed to environmental challenges and contains skin-resident immune cells, including mast cells (MCs) and CD8 T cells that act as sentinels for pathogens and environmental antigens. Human skin MCs and their mediators participate in the maintenance of tissue homeostasis and regulate the recruitment and activity of immune cells involved in the pathogenesis of skin diseases. The cutaneous CD8 T cell compartment is comprised of long-persisting resident memory T cells (TRM) and migratory or recirculating cells; both populations provide durable site immune surveillance. Several lines of evidence indicate that MC-derived products, such as CCL5 and TNF-α, modulate the migration and function of CD8 T cells. Conversely, activated CD8 T cells induce the upregulation of MC costimulatory molecules. Moreover, the close apposition of MCs and CD8 T cells has been recently identified in the skin of several dermatoses, such as alopecia areata. This review outlines the current knowledge about bidirectional interactions between human MCs and CD8 T cells, analyses the alteration of their communication in the context of three common skin disorders in which these cells have been found altered in number or function—psoriasis, atopic dermatitis, and vitiligo—and discusses the current unanswered questions.

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Section: Mast Cells and Cd8 T Cells In Tissue Homeostasis And Diseasementioning

confidence: 98%

Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

Chen

Griffiths

Bulfone–Paus∥

2023

IJMS

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“…MCs are abundant in the skin in a spindle-shaped form along blood vessels in a steady state, whereas they are round in an inflammatory condition [24,22]. Like other CTMCs and MMCs, skin MC survival depends on SCF-c-kit signaling [25][26][27].…”

Section: In Homeostatic Conditionsmentioning

confidence: 99%

“…MCs are increased in many skin inflammatory diseases such as AD [21,40] and psoriasis [41,42]. The increase of MCs in the inflamed skin was also observed in murine AD models [23,[43][44][45]22], but little is investigated about the underlying mechanism.…”

Section: In Atopic Dermatitis Skinmentioning

confidence: 99%

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Mast cells in type 2 skin inflammation: Maintenance and function

et al. 2023

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Mast cells (MCs) are immune cells residing in tissues and playing indispensable roles in maintaining homeostasis and inflammatory states. Skin lesions associated with atopic dermatitis (AD) and type 2 skin inflammation display an increment in MCs, which have both pro‐ and anti‐inflammatory effects. The direct and indirect activations of skin MCs by environmental factors such as Staphylococcus aureus can instigate type 2 skin inflammation in AD with poorly understood mechanisms. Furthermore, both IgE‐dependent and ‐independent degranulation of MCs contribute to pruritus in AD. Conversely, MCs suppress type 2 skin inflammation by promoting Treg expansion through IL‐2 secretion in the spleen. Moreover, skin MCs can upregulate gene expression involved in skin barrier function, thus mitigating AD‐like inflammation. These functional variances of MCs in AD could stem from differences in experimental systems, their localization, and origins. In this review, we will focus on how MCs are maintained in the skin under homeostatic and inflammatory conditions, and how they are involved in the pathogenesis of type 2 skin inflammation.

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“…However, it is important to note that these studies on basophil heterogeneity used Mcpt8 as a basophil-specific marker for transcriptional studies and cell-depletion. Recent studies have suggested that integrinβ7 + mast cells also express Mcpt8 both in the skin and the lung under allergic inflammation ( 54 , 55 ). Nevertheless, how basophils could acquire distinct identities in peripheral organs remains to be fully clarified and addressed.…”

Section: The Emergence Of Skin-homing Basophilsmentioning

confidence: 99%

Skin-homing basophils and beyond

Shibuya

Kim

2022

Front. Immunol.

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Basophils have been implicated in type 2 inflammation and numerous disorders in the skin such as helminth infection, atopic dermatitis, and urticaria. Although similar in form and function to tissue-resident mast cells, classical studies on basophils have centered on those from the hematopoietic compartment. However, increasing studies in tissues like the skin demonstrate that basophils may take on particular characteristics by responding to unique developmental, chemotactic, and activation cues. Herein, we highlight how recent studies in barrier immunology suggest the presence of skin-homing basophils that harbor a unique identity in terms of phenotype, function, and motility. These concepts may uniquely inform how basophils contribute to diseases at multiple epithelial surfaces and our ability to therapeutically target the innate immune system in disease.

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Infiltration and local differentiation of bone marrow–derived integrinβ7-positive mast cell progenitors in atopic dermatitis–like skin

Cited by 9 publications

References 45 publications

Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

Mast cells in type 2 skin inflammation: Maintenance and function

Skin-homing basophils and beyond

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