Infiltrating lobular carcinoma of the breast

Ashikari, Roy; Huvos, Andrew G.; Urban, Jerome A.; Robbins, Guy F.

doi:10.1002/1097-0142(197301)31:1<110::aid-cncr2820310115>3.0.co;2-v

Cited by 112 publications

(36 citation statements)

References 11 publications

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“…Previous suggestions (Ashikari et al, 1973;Wheeler & Enterline, 1976;Nielson et al, 1986) that bilateral cancers are more frequently seen with lobular carcinomas are confirmed. A possible explanation arises from the finding of lobular carcinoma in situ (LCIS) in 66% of ipsilateral (Dixon et al, 1982) and 35% of contralateral breasts (Urban, 1967) in patients with invasive lobular carcinoma; LCIS lesions can also progress to invasive carcinoma (Haagensen et al, 1978;Rosen et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

A comparison of the clinical metastatic patterns of invasive lobular and ductal carcinomas of the breast

Dixon

Ellis²,

Elston³

et al. 1991

Br J Cancer

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Summary Seventy seven patients with metastases from an invasive lobular carcinoma of the breast have been compared with 72 consecutive metastatic ductal carcinomas. There was no difference in the metastatic free interval between the two groups. A distinct pattern of clinical presentation of metastases was seen; hepatic (P = 0.01) and peritoneal metastases (P =0.0003) occurred more commonly in lobular tumours. Bilateral cancers were more common in the lobular group (P = 0.01). No difference was seen in terms of meningeal and pulmonary metastases. Survival after metastases was significantly longer in patients with metastatic lobular carcinoma (P = 0.02).Differences in cell morphology, growth patterns and tissue response allow for the division of invasive adenocarcinomas of the breast into specific types (Gallagher, 1984); infiltrating ductal (80%) and lobular (8-14.7%) carcinomas are the commonest (Martinez & Azzopardi, 1979;Dixon et al., 1982). The largest sub-group (65-68%) show no specific characteristics and have been termed carcinoma NOS not otherwise specified (Fisher et al., 1975) or ductal NOS (Dixon et al., 1985). These histological differences have been shown to have important influences upon prognosis (Gallagher, 1984;Dixon et al., 1985). A study based on clinical and post-mortem material (Harris et al., 1984) showed that lobular carcinoma of the breast had a distinctly different metastatic pattern to that seen in ductal carcinomas: lobular types were associated with carcinomatous meningitis and both peritoneal and retroperitoneal metastases of a diffuse micro-nodular fashion; lung parenchymal metastases were more common with ductal tumours. This series of lobular carcinomas has been studied in an attempt to verify this observation. (Mantel, 1966). Fisher's exact test was used to determine statistical differences between sites of metastases. Patients and methods ResultsThe median age at development of metastases was 56 years (28-72 years) for invasive lobular tumours and 54 years (37-70 years) for ductal carcinomas (not significant); medial follow-up time for both groups was 72 months. The sites of distant metastases as diagnosed clinically are shown in Table I. Hepatic (P = 0.01) and peritoneal (0.0003) metastases were detected significantly more often in lobular carcinomas. The clinical presentation of the 14 lobular peritoneal metastases included: retroperitoneal ureteric obstruction (3), large bowel obstruction and perforation (1), 'linitis plastica' of the stomach (2), small bowel obstruction (3), omental masses (5). The six patients with obstructive/dysphagic symptoms underwent laparotomy, the operative findings in each case being tiny serosal nodules, widespread throughout the bowel. These nodules were confluent at the site of obstruction.No significant difference existed between the two pathological types in terms of skeletal, pulmonary, pleural and cerebral metastases. Eighteen of the 149 patients with metastases developed metachronous contralateral cancers (12%), 14 of these occurred in the ...

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Section: Discussionmentioning

confidence: 99%

A comparison of the clinical metastatic patterns of invasive lobular and ductal carcinomas of the breast

Dixon

Ellis²,

Elston³

et al. 1991

Br J Cancer

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“…9 Finally, ILC has a higher incidence of bilaterality, multifocality, and multicentricity than IDC. 10 The same biologic characteristics that make ILC difficult to detect clinically or mammographically can make it harder to detect axillary lymph node metastases. 11 Nodes may remain nonpalpable even when extensively involved, and the bland-looking metastatic tumor cells may mimic histiocytes or other benign cell types.…”

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confidence: 85%

Treatment Trends in Early-Stage Invasive Lobular Carcinoma

Singletary¹,

Patel-Parekh²,

Bland³

2005

Annals of Surgery

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“…Some long-term follow-up studies have shown a trend to later locoregional recurrence [11]. In addition, it has been reported that ILC is less responsive to chemotherapy [3,21], lacks potential benefit of HER2 targeted therapy [16,17], being typically HER2 negative, but is more often HR positive and responsive to adjuvant hormonal therapy (HT) [11,22,23]. Reported prognosis of ILC varies and has been reported to be worse [1,9,[24][25][26][27], no different [17,[28][29][30][31][32], or better [6] than that with IDC.…”

Section: Introductionmentioning

confidence: 99%