Infiltração intra‐articular em pacientes com artrite idiopática juvenil: fatores associados à boa resposta

Cunha, Ana Luiza Garcia; Silva, Vanessa Bugni Miotto e; Osaku, Fabiane Mitie; Niemxeski, Luísa Brasil; Furtado, Rita Nely Vilar; Natour, Jamil; Terreri, Maria Teresa

doi:10.1016/j.rbr.2015.08.010

Cited by 8 publications

(2 citation statements)

References 18 publications

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“…Factors previously found to impact positively IACI outcomes were not seen in this cohort, including more elevated ESR [10], younger age at diagnosis, and presence of uveitis [35]. The average time to recurrent arthritis in this cohort, 10 months, is shorter than that seen in recent studies: 12.5 months [36] and 18.1 months [35]. Although the previously mentioned studies examined the outcome of a variety of joint injections, most were knees.…”

Section: Discussionmentioning

confidence: 75%

“…There is evidence that injection of a joint, including the knee, earlier in the disease course may positively affect outcomes, including protracted response [11]. Factors previously found to impact positively IACI outcomes were not seen in this cohort, including more elevated ESR [10], younger age at diagnosis, and presence of uveitis [35]. The average time to recurrent arthritis in this cohort, 10 months, is shorter than that seen in recent studies: 12.5 months [36] and 18.1 months [35].…”

Section: Discussionmentioning

confidence: 92%

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Retrospective review of immobilization vs. immediate resumption of activity in patients with Oligoarticular juvenile idiopathic arthritis following knee injections

et al. 2019

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Background Intraarticular corticosteroid injection (IACI) is one of the most common treatments in oligoarticular Juvenile Idiopathic Arthritis (JIA). Activity recommendations following injection vary, as there are no published studies on splinting JIA patients post-IACI (splinting is a form of rest). Texas Scottish Rite Hospital for Children (TSRH) splints patients post-IACI for 24 h while The Children’s Hospital of Philadelphia (CHOP) does not. The aim of this study was to compare the number of cases of recurrent arthritis following IACI between these two post-injection practices. Methods Data were retrospectively collected at CHOP and TSRH. Patients diagnosed with oligoarticular JIA according to International League of Associations for Rheumatology (ILAR) criteria (2nd revision, 2001) between 2008 and 2010 were included. Bivariate analysis (Wilcoxon rank-sum tests, chi-squared tests) was run to assess differences in outcomes by site. Inverse probability of treatment weighted Cox regression was employed to adjust for site differences. Results The population at TSRH was younger than at CHOP ( p < 0.05) and had more whites ( p = 0.03). Disease duration was significantly longer at TSRH than at CHOP (0.40 vs. 0.74 years, p = 0.014). More children were on biologics at the time of injection at CHOP (p < 0.05). The baseline physician global ( p < 0.001) was higher at CHOP, as was the joint disease severity (p < 0.001). CHOP had fewer reoccurrences of knee arthritis compared to TSRH: 26% vs 38% ( p = 0.14). Conclusions The baseline populations were different in that the TSRH group had more whites and Hispanics, were younger and, perhaps, had less severe disease than CHOP. Patients treated with post-injection splinting had a trend toward more arthritis reoccurrence (38% vs. 26%, p = 0.14). Splinting is not clearly beneficial post-injection. Trial registration This is an observational study, so it is not applicable. Electronic supplementary material The online version of this article (10.1186/s12969-019-0339-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 92%

Retrospective review of immobilization vs. immediate resumption of activity in patients with Oligoarticular juvenile idiopathic arthritis following knee injections

et al. 2019

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Overlap of International League of Associations for Rheumatology and Preliminary Pediatric Rheumatology International Trials Organization Classification Criteria for Nonsystemic Juvenile Idiopathic Arthritis in an Established UK Multicentre Inception Cohort

Shoop‐Worrall,

Macintyre,

Ciurtin

et al. 2024

Arthritis Care & Research

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ObjectivesTo assess the degree of overlap between existing International League of Associations for Rheumatology (ILAR) and preliminary Pediatric Rheumatology International Trials Organization (PRINTO) classification criteria for JIA.MethodsParticipants from the Childhood Arthritis Prospective Study, a multicentre UK JIA inception cohort, were classified using the PRINTO and ILAR classification criteria into distinct categories. Systemic JIA was excluded as several classification items were not collected in this cohort. Adaptations to PRINTO criteria were required to apply to a UK healthcare setting, including limiting the number of blood biomarker tests required. The overlap between categories under the two systems was determined and any differences in characteristics between groups described.ResultsA total of 1,223 children and young people with a physician's diagnosis of JIA were included. Using PRINTO criteria, the majority of children had “Other JIA” (69.5%). There was a high degree of overlap (91%) between the PRINTO enthesitis/spondylitis‐ and ILAR enthesitis‐related JIA categories. The PRINTO RF‐positive category was composed of 48% ILAR RF‐positive polyarthritis and 52% undifferentiated JIA. The early‐onset ANA‐positive PRINTO category was largely composed of ILAR oligoarthritis (50%), RF‐negative polyarthritis (24%) and undifferentiated JIA (23%). Few children were unclassified under PRINTO (n=3) and would previously have been classified as enthesitis‐related JIA (n=1) and undifferentiated JIA (n=2) under ILAR.ConclusionUnder the preliminary PRINTO classification criteria for childhood arthritis, most children are not yet classified into a named category. These data can help support further delineation of the PRINTO criteria to ensure homogenous groups of children can be identified.

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Identification of potential peripheral blood diagnostic biomarkers for patients with juvenile idiopathic arthritis by bioinformatics analysis

Xue

Chen

et al. 2016

Rheumatol Int

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Juvenile idiopathic arthritis (JIA) is common childhood rheumatic disease harming children health. However, there is still lack of effective biomarkers for diagnosis JIA at early onset. We aim to construct a classification model to predict JIA disease. The peripheral blood gene expression profile data of JIA were downloaded from GEO database. We compared and analyzed differentially expressed genes (DEGs) between different JIA samples through Pearson's correlation coefficient method and unsupervised clustering analysis. Diagnostic model were constructed based on the deviation pathway through bioinformatics method. Eighteen specific correlated DEGs were obtained, but the correlations altered in different disease states. Although most JIA and control samples were clustered by unsupervised clustering analysis, respectively, a few JIA samples could not be clustered well. Four co-expression networks were next constructed with gene connections dynamically altered under variable conditions. Eight signaling pathways were significantly enriched including B/T cell receptor, ErbB and MAPK signaling pathways. The deviation scores of pathways were calculated. Applying these eight signaling pathways as feature to construct a classification model could predict JIA disease with high accuracies. Our data provide some light into pathogenic mechanism of JIA, the specific gene sets and the related signaling pathways may be potential biomarkers for diagnosis or therapeutic targets of JIA.

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Infiltração intra‐articular em pacientes com artrite idiopática juvenil: fatores associados à boa resposta

Abstract: In our study, more than half of the joints showed a good response to IIC. Younger patients at diagnosis and uveitis during the course of the disease had good response to IIC. Knees, wrists and elbows were the joints that best responded to IIC. IIC proved to be a safe procedure.

Cited by 8 publications

References 18 publications

Retrospective review of immobilization vs. immediate resumption of activity in patients with Oligoarticular juvenile idiopathic arthritis following knee injections

Retrospective review of immobilization vs. immediate resumption of activity in patients with Oligoarticular juvenile idiopathic arthritis following knee injections

Overlap of International League of Associations for Rheumatology and Preliminary Pediatric Rheumatology International Trials Organization Classification Criteria for Nonsystemic Juvenile Idiopathic Arthritis in an Established UK Multicentre Inception Cohort

Identification of potential peripheral blood diagnostic biomarkers for patients with juvenile idiopathic arthritis by bioinformatics analysis

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