Infertility in women with systemic autoimmune diseases

Khizroeva, J. Kh.; Nalli, Cecilia; Bitsadze, Victoria; Lojacono, Andrea; Zatti, Sonia; Andréoli, Laura; Tincani, Anǵela; Shoenfeld, Yehuda; Makatsariya, Alexander

doi:10.1016/j.beem.2019.101369

Cited by 74 publications

(45 citation statements)

References 46 publications

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“…Historically, when compared with women without autoimmune diseases, women with SLE have been reported to have similar rates of infertility (Ekblom-Kullberg et al, 2009). Importantly, this is not the case in patients who have undergone treatment of SLE with alkylating agents such as cyclophosphamide (CYC), which can deplete oocyte reserve and lead to premature ovarian failure (Di Mario et al, 2019;Khizroeva et al, 2019). However, recent epidemiologic studies have indicated that women with SLE comprise a disproportionately large percentage of patients with infertility (Hickman & Gordon, 2011).…”

Section: Fertilitymentioning

confidence: 99%

“…With regard to the impact of SLE on family planning, women with SLE do have fewer biologic children than desired-a 2012 survey of women with SLE and rheumatoid arthritis concluded that patient concerns about the impact of rheumatic disease on their offspring played a significant role in women having fewer children than initially planned (Clowse, Chakravarty, Costenbader, Chambers, & Michaud, 2012;Khizroeva et al, 2019).…”

Section: Fertilitymentioning

confidence: 99%

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Pregnancy in systemic lupus erythematosus

Polic

Običan

2020

Birth Defects Research

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Objectives: Systemic lupus erythematosus (SLE) is a chronic illness that often affects women of reproductive age. The objectives of this article are to review the impact of SLE on pregnancy and current management strategies, including commonly used therapies. Methods: We conducted a review of available literature on the clinical course of SLE, diagnosis, management and pregnancy complications. Results: SLE has a variable clinical course characterized by flares and periods of remission and can present unique challenges in the management of obstetric patients. Pregnancy in patients with SLE is associated with multiple risks, including fetal loss, preterm birth, fetal growth restriction, and hypertensive disease. With advancements in disease treatment, many women have favorable pregnancy outcomes, but appropriate preconception counseling and disease management remain important tools in reducing complications. Conclusion: Given the implications SLE can have on women of reproductive age and in pregnancy, understanding the disease course and management is important in order to optimize pregnancy outcomes.

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Section: Fertilitymentioning

confidence: 99%

Section: Fertilitymentioning

confidence: 99%

Pregnancy in systemic lupus erythematosus

Polic

Običan

2020

Birth Defects Research

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“…The fertility rate is lower in patients with other inflammatory diseases such as psoriasis [ 6 ], rheumatoid arthritis and inflammatory bowel disease [ 7 ]. HS is the dermatological disease with the greatest impact on patients’ quality of life [ 8 ] and has a similar impact to other non-dermatological conditions such as cardiovascular disease, cancer, diabetes mellitus and chronic obstructive pulmonary disease [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Reproductive Potential and Outcomes in Patients with Hidradenitis Suppurativa: Clinical Profile and Therapeutic Implications

Montero‐Vílchez

Salvador‐Rodríguez

Rodriguez-Tejero

et al. 2021

Life

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There are scarce data available regarding the impact of hidradenitis suppurativa (HS) on fertility, course and outcome of pregnancy and risk associated with treatments. The aims of this study are (1) to describe the clinical profile of HS women of childbearing age with and without accomplished reproductive desires and (2) to describe the prescribed treatments based on the fulfillment of reproductive intentions. We conducted a prospective observational study that included 104 HS women of childbearing age, 50.96% (53/104) with unfulfilled reproductive desires. These women were younger (29.08 vs. 42.06 years, p < 0.001), less frequently married and higher educated than women with fulfilled reproductive desires. Their age of disease onset was lower, but disease duration was shorter, in concordance with a lower International Hidradenitis Suppurativa Severity Score System (IHS4) and lower number of draining tunnels. Combined oral contraceptives were more frequently prescribed in women with unfulfilled reproductive desires (30.19% vs. 9.80%, p = 0.013) while biologics were less used in this group (3.77% vs. 13.73%, p = 0.08). In conclusion, a higher educational level and an earlier disease onset, with potential implications in finding a partner, may make the fulfillment of reproductive desires difficult for patients with HS. This study could help clinicians to achieve a better understanding of the specific characteristics of HS during childbearing age and consider reproductive desires when making treatment decisions.

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“…Some of these problems were amplified by the continuous postponing of the average age of pregnancy, and also by some changes in women sexual behavior (e.g., number of sex partners, higher incidence of sexually transmitted diseases) [5]. Increasing incidences of diabetes, hypertension, hypothyroidism and lifestyle diseases also have negative consequences in female fertility [6], not to mention the growth of systemic autoimmune diseases [7]. Despite these improvements on the comprehension of infertility, its prevalence, and treatment seeking, much more research is necessary [8].…”

Section: Introductionmentioning

confidence: 99%

Clinicians’ Perceptions of Norwegian Women’s Experiences of Infertility Diseases

Fernandes

Skotnes

Major

et al. 2020

IJERPH

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Background: Norway has one of the best health systems in the world. However, it has a low birth rate, which decreased by 21.2% between 2009 and 2018, and one of the highest rates of infertility prevalence. The aim of this study is to understand how Norwegian doctors perceive female infertility diseases, namely those that are more difficult to diagnose and to treat, and that are more common in their practice. Method: Descriptive qualitative study was conducted with gynecologists and general practitioners. The sample resulted from the establishment of five criteria and on the doctors’ acceptance to participate in this study. Our sample comprised thirteen highly qualified and experienced doctors. Qualitative content analysis was the method chosen to analyze the collected data. Results: Clinical diseases (polycystic ovary syndrome, endometriosis and vulvodynia) and consequences of these diseases were the pinpointed themes. These led to a set of sub-themes: the main symptoms and the treatment of the diseases, from the perspective of both women and doctors (stigmatization, disturbances in women’s daily life, diagnostic delay, and governmental support). Conclusions: The three most relevant disorders mentioned were polycystic ovary syndrome, endometriosis and vulvodynia. These diseases cause several impacts on the lives of women, because they feel stigmatized and limited in their daily life and sexuality, and the diagnosis of these diseases takes too much time. Governments should better redistribute the financing of women’s health and allocate resources to specialized centers.

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Infertility in women with systemic autoimmune diseases

Cited by 74 publications

References 46 publications

Pregnancy in systemic lupus erythematosus

Pregnancy in systemic lupus erythematosus

Reproductive Potential and Outcomes in Patients with Hidradenitis Suppurativa: Clinical Profile and Therapeutic Implications

Clinicians’ Perceptions of Norwegian Women’s Experiences of Infertility Diseases

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