Infertility in men with inflammatory bowel disease

Shin, Takeshi; Okada, Hiroshi

doi:10.4292/wjgpt.v7.i3.361

Cited by 38 publications

(44 citation statements)

References 83 publications

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“…In agreement with results of the present study, Skondras et al 24 reported that cyclosporine enhances the inflammatory processes in the testis, possibly by increasing the expression of TGF‐β1, TNF‐α, IL‐6 and IL‐1β, which in turn leads to significant DNA damage which directly affects male fertility. Moreover, Shin and Okada 25 found that treatment of inflammatory bowel diseases with cyclosporine may affect NF‐κB signalling pathways which together with increased expression of TGF‐β1 may initiate massive release of the proinflammatory cytokines such as TNF‐α which is the main mediator of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of cyclosporine‐induced testicular toxicity by carvedilol and/or alpha‐lipoic acid: Role of TGF‐β1, the proinflammatory cytokines, Nrf2/HO‐1 pathway and apoptosis

Kabel

Salama

Alghorabi

et al. 2020

Clin Exp Pharma Physio

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Cyclosporine is an immunosuppressive agent that is used to prevent organ rejection after organ transplantation. Due to the widespread use of this type of surgery, the effect of cyclosporine on reproduction and fertility should have a specific interest. Our aim was to assess the effect of carvedilol and/or alpha-lipoic acid on cyclosporineinduced testicular toxicity in rats. Sixty male Wistar rats were divided into six equal groups: Control; cyclosporine; cyclosporine + carvedilol; cyclosporine + alpha-lipoic acid; cyclosporine + carboxymethyl cellulose; and cyclosporine + carvedilol +alphalipoic acid. Food intake, testis weight, testicular functions, serum testosterone, luteinizing hormone and follicle-stimulating hormone were measured. Also, testicular tissue 3 β-hydroxysteroid dehydrogenase, 17 β-hydroxysteroid dehydrogenase, paroxonase-1, proinflammatory cytokines, transforming growth factor beta-1, nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Heme oxygenase-1 (HO-1) content and sperm characteristics were determined. Parts of the testes were subjected to histopathological and electron microscopic examination. The carvedilol/alpha-lipoic acid combination restored the food intake, testicular weight and functions, sperm characteristics, hormonal profile and the antioxidant defences compared to the use of each of these drugs alone. Also, this combination significantly ameliorated inflammation (P < .05) and induced significant increase in tissue Nrf2/HO-1 content (P < .05) and significant improvement of the histopathological and electron microscopic picture (P < .05) compared to the use of each of these drugs alone. So, carvedilol/alpha-lipoic acid combination might represent a novel therapeutic strategy to ameliorate testicular damage induced by cyclosporine. K E Y W O R D Salpha-lipoic acid, carvedilol, cyclosporine, rats, testis

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Section: Discussionmentioning

confidence: 99%

Amelioration of cyclosporine‐induced testicular toxicity by carvedilol and/or alpha‐lipoic acid: Role of TGF‐β1, the proinflammatory cytokines, Nrf2/HO‐1 pathway and apoptosis

Kabel

Salama

Alghorabi

et al. 2020

Clin Exp Pharma Physio

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“…In addition, an IRA operation requires less pelvic dissection, which means lower risk of pelvic infection or adhesions and a future better fecundability and fertility, for both men and women, than in IPAA patients [24,[44][45][46].…”

Section: Association Between Macroscopic and Microscopic Grades Of Inmentioning

confidence: 99%

Anorectal Function After Ileo-Rectal Anastomosis Is Better than Pelvic Pouch in Selected Ulcerative Colitis Patients

et al. 2019

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Background With a lifelong perspective, 12% of ulcerative colitis patients will need a colectomy. Further reconstruction via ileo-rectal anastomosis or pouch can be affected by patients' perspective of their quality of life after surgery. Aim To assess the function and quality of life after restorative procedures with either ileo-rectal anastomosis or ileal pouchanal anastomosis in relation to the inflammatory activity on endoscopy and in biopsies. Method A total of 143 UC patients operated with subtotal colectomy and ileo-rectal anastomosis or pouches between 1992 and 2006 at Linköping University Hospital were invited to participate. Those who completed the validated questionnaires (Öresland score, SF-36, Short Health Scale) were offered an endoscopic evaluation including multiple biopsies. Associations between anorectal function and quality of life with type of restorative procedure and severity of endoscopic and histopathologic grading of inflammation were evaluated. Results Some 77 (53.9%) eligible patients completed questionnaires, of these 68 (88.3%) underwent endoscopic evaluation after a median follow-up of 12.5 (range 3.5-19.4) years after restorative procedure. Patients with ileo-rectal anastomosis reported better overall Öresland score: median = 3 (IQR 2-5) for ileo-rectal anastomosis (n = 38) and 10 (IQR 5-15) for pouch patients (n = 39) (p < 0.001). Anorectal function (Öresland score) and endoscopic findings (Baron-Ginsberg score) were positively correlated in pouch patients (tau: 0.28, p = 0.006). Conclusion Patients operated with ileo-rectal anastomosis reported better continence compared to pouches. Minor differences were noted regarding the quality of life. Ileo-rectal anastomosis is a valid option for properly selected ulcerative colitis patients if strict postoperative endoscopic surveillance is carried out. Keywords Ulcerative colitis • Ileo-rectal anastomosis • Ileal pouch-anal anastomosis • Quality of life Abbreviations BG Baron-Ginsberg score CCGQoL Cleveland clinic global quality of life score IBD Inflammatory bowel disease IPAA Ileal pouch-anal anastomosis IRA Ileo-rectal anastomosis IQR Interquartile range OR Odds ratio SF-36 Short form 36 questions SHS Short health scale tau Kendall-tau correlation coefficient UC Ulcerative colitis VAS Visual analogue scale QoL Quality of life Electronic supplementary material The online version of this article (

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“…CED-erkrankte Männer sollten aktiv auf einen möglichen Kinderwunsch angesprochen werden, um (unbegründete?) Ängste zu erfahren und diesen eventuell argumentativ zu begegnen [17,18].…”

Section: Andere Medikamenteunclassified

Schwangerschaft und Stillen mit chronisch entzündlichen Darmerkrankungen

Teich¹,

Stallmach²

2017

Gastroenterologie up2date

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Infertility in men with inflammatory bowel disease

Cited by 38 publications

References 83 publications

Amelioration of cyclosporine‐induced testicular toxicity by carvedilol and/or alpha‐lipoic acid: Role of TGF‐β1, the proinflammatory cytokines, Nrf2/HO‐1 pathway and apoptosis

Amelioration of cyclosporine‐induced testicular toxicity by carvedilol and/or alpha‐lipoic acid: Role of TGF‐β1, the proinflammatory cytokines, Nrf2/HO‐1 pathway and apoptosis

Anorectal Function After Ileo-Rectal Anastomosis Is Better than Pelvic Pouch in Selected Ulcerative Colitis Patients

Schwangerschaft und Stillen mit chronisch entzündlichen Darmerkrankungen

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