Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review

Zakhem, George A.; Motosko, Catherine C.; Mu, Euphemia W.; Ho, Roger S.

doi:10.1016/j.jaad.2018.09.031

Cited by 22 publications

(30 citation statements)

References 30 publications

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“…In this study, synthetic retinoids-including etretinate, acitretin, isotretinoin, and retinoic acid-were reported to show dose-dependent inhibition of fructolysis that evaluates sperm motility in ejaculated human spermatozoa in vitro [11]. However, other studies showed no effect of the drug on spermatogenesis.…”

Section: Discussionmentioning

confidence: 86%

Untitled

2020

Our Dermatol Online

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Acitretin is a second-generation oral retinoid used by dermatologists for the treatment of dermatological disorders such as psoriasis, pityriasis rubra pilaris, and lichen planus [1]. Acitretin may cause some common side effects such as dry skin and mucosa, hyperlipidemia, muscle and joint pain, and hepatitis [2]. Erectile dysfunction is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse. Erectile dysfunction may be due to various reasons, including psychogenic and organic factors, endocrine disorders, and drug use [3]. Data on the effect of acitretin on sexual function is limited. The literature provides no studies that would investigate whether acitretin causes erectile dysfunction in humans. Therefore, in this study, we aimed at investigating whether patients taking acitretin develop erectile dysfunction. MATERIALS AND METHODS The study included 40 male patients who presented to the Dermatology Polyclinic of Okmeydanı Training and Research Hospital between October 2014 and April 2016 and started treatment with acitretin for various dermatological disorders. Exclusion criteria included psychogenic and psychiatric disorders, diabetes mellitus, ABSTRACT Background: Acitretin is a second-generation oral retinoid compound used as a treatment option for various dermatological disorders. The effects of the drug on erectile function have not been fully determined yet. We aimed at investigating whether patients taking acitretin develop erectile dysfunction (ED). Materials and Methods: The study included 40 male patients who presented to the Dermatology Polyclinic of Okmeydanı Training and Research Hospital between October 2014 and April 2016 and started treatment with acitretin. Exclusion criteria included psychogenic and psychiatric disorders, neurological disorders such as multiple sclerosis, diabetes mellitus and endocrine disorders, arteriogenic and venous disorders, alcohol and tobacco use, penile disorders, obesity, a history of drug use, a score of above 10 points in the Beck Depression Inventory (BDI), hyperlipidemia, and an age above 65 years. Having obtained the informed consent, the patients were asked to complete the International Index of Erectile Function (IIEF) questionnaire before and after three months of therapy. The patients were evaluated by calculating their scores and a statistical analysis was performed. Results: A total of 40 patients were included in the study. A comparison of the IIEF scores before and after three months of therapy revealed that the scores were significantly lower after three months of therapy (P < 0.0001). ED was diagnosed in 30 patients (75%) at the beginning of therapy and in 35 patients (87.5%) after three months of therapy. A comparison of baseline and 3-month IIEF grades revealed that the number of patients in the second group was significantly greater after three months of therapy with the drug (P = 0.001). When the percentage of patients with erectile dysfunction at the baseline and after three months of ther...

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Section: Discussionmentioning

confidence: 86%

Untitled

2020

Our Dermatol Online

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“…According to the potential side effects of hydroquinone such as ochronosis as well as its cytotoxicity and teratogenicity, methimazole might be a reasonable alternative in many patients particularly as a part of combined therapy. 19 Although there were some concerns about the adverse effect of methimazole on thyroid glands via systemic absorption, some of the aforementioned studies confirmed the lack of systemic side effect of methimazole indicated by serum TSH level. 17,18 In a study by Kasraee et al, there were no alterations in the serum level of TSH, free thyroxin, and free triiodothyronine of 20 patients with melasma, who were treated with once daily application of topical methimazole for 6 weeks.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of topical 5% methimazole vs 4% hydroquinone in the treatment of melasma: A randomized controlled trial

Gheisari

Dadkhahfar

Olamaei

et al. 2019

J of Cosmetic Dermatology

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Melasma is a common hyperpigmentary disorder over the sun-exposed areas of the face which affect mostly women with Fitzpatrick skin type III-V. 1,2 Various factors may exacerbate this condition including sun exposure, hyperestrogenic states like pregnancy, oral contraceptive pills, hormone replacement therapy, other medications (eg, antiepileptic and phototoxic drugs), and disorders (eg, autoimmune thyroid disease). 3 Melasma is a clinical result of the melanogenesis pathway overactivity leading to increases in melanin deposition within the epidermis, dermis, or both layers of the affected skin. 4 The treatment of melasma is difficult, and it has a significant negative impact on patients' quality of life. 5 Numerous treatment modalities are available for treatment of melasma including topical preparations, chemical peels, microdermabrasion, laser, and lights along with restrict avoidance of exacerbating factors such as sun exposure. 2 Nevertheless, none of these remedies are able to achieve complete clearance of

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“…We will analyze the tweets from the patients with lupus to identify the issues and concerns they express regarding their reproductive health. Previous research has identified multiple challenges experienced by patients with SLE, for example, fertility preservation, optimal care during pregnancies, risks of adverse maternal or fetal outcomes, safety of contraceptive methods for women, and effects of dermatologic medications on male fertility [ 44 - 47 ].…”

Section: Methodsmentioning

confidence: 99%

Insights From Twitter Conversations on Lupus and Reproductive Health: Protocol for a Content Analysis

Stens¹,

Weisman²,

Reuter³

2020

JMIR Res Protoc

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Background Systemic lupus erythematosus (SLE) is the most common form of lupus. It is a chronic autoimmune disease that predominantly affects women of reproductive age, impacting contraception, fertility, and pregnancy. Although clinic-based studies have contributed to an increased understanding of reproductive health care needs of patients with SLE, misinformation abounds and perspectives on reproductive health issues among patients with lupus remain poorly understood. Social networks such as Twitter may serve as a data source for exploring how lupus patients communicate about their health issues, thus adding a dimension to enrich our understanding of communication regarding reproductive health in this unique patient population. Objective The objective of this study is to conduct a content analysis of Twitter data published by users in English in the United States from September 1, 2017, to October 31, 2018, in order to examine people’s perspectives on reproductive health among patients with lupus. Methods This study will analyze user-generated posts that include keywords related to lupus and reproductive health from Twitter. To access public Twitter user data, we will use Symplur Signals, a health care social media analytics platform. Text classifiers will be used to identify topics in posts. Posts will be classified manually into the a priori and emergent categories. Based on the information available in a user’s Twitter profile (ie, username, description, and profile image), we will further attempt to characterize the user who generated the post. We will use descriptive statistics to analyze the data and identify the most prevalent topics in the Twitter content among patients with lupus. Results This study has been funded by the National Center for Advancing Translational Science (NCATS) through their Clinical and Translational Science Awards program. The Institutional Review Board at the University of Southern California approved the study (HS-18-00912). Data extraction and cleaning are complete. We obtained 47,715 Twitter posts containing terms related to “lupus” from users in the United States, published in English between September 1, 2017, and October 31, 2018. We will include 40,885 posts in the analysis, which will be completed in fall 2020. This study was supported by funds from the has been funded by the National Center for Advancing Translational Science (NCATS) through their Clinical and Translational Science Awards program. Conclusions The findings from this study will provide pilot data on the use of Twitter among patients with lupus. Our findings will shed light on whether Twitter is a promising data source for learning about reproductive health issues expressed among patients with lupus. The data will also help to determine whether Twitter can serve as a potential outreach platform for raising awareness of lupus and reproductive health and for implementing relevant health interventions. International Registered Report Identifier (IRRID) DERR1-10.2196/15623

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Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review

Cited by 22 publications

References 30 publications

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The efficacy and safety of topical 5% methimazole vs 4% hydroquinone in the treatment of melasma: A randomized controlled trial

Insights From Twitter Conversations on Lupus and Reproductive Health: Protocol for a Content Analysis

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