A B S T R A C TObjectives.The purpose of this study was to assess the association between subfertility and spontaneous abortion.Methods. A total of 1572 women in New York and Vermont reported 3269 pregnancies between 1980 and 1990 and were able to provide an estimate of the waiting time to conception for 2967. Subfertility was defined as a delay of 1 year or more before a recognized conception was achieved. Rates of spontaneous abortion were determined among women with and without subfertility, and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated via multiple logistic regression.Results. Spontaneous abortion rates were 23.0% in pregnancies preceded by subfertility and 14.0% in pregnancies without impaired fertility (adjusted OR= 1.71, 95% CI = 1.26, 2.94). The attributable risk of spontaneous abortion associated with subfertility was 6.2%.Conclusions. Delays in achieving conception and increased rates of pregnancy loss share common risk factors, such as advancing age (over 35 years), cigarette smoking, 1,2 and occupational exposures to nitrous oxide 3,4 or ethylene glycol ethers. 5,6 Among women planning a pregnancy, waiting times to conception exceeding 6 months have been associated with spontaneous abortion.7 Also, women with a history of lower fecundity are more likely to have had an earlier spontaneous abortion, 8 and reanalyses of data from the Collaborative Perinatal Study suggest a weak association between prolonged waiting time to conception and spontaneous abortion. Furthermore, women with a history of subfertility have been shown to have increased rates of subclinical early pregnancy loss, as detected via human chorionic gonadotropin, relative to women without a history of impaired fertility. 10 The present study used data from a retrospective cohort investigation to assess whether women who report delays in achieving a recognized conception have increased rates of spontaneous abortion.
MethodsThe study was conducted at 2 semiconductor manufacturing facilities in Fishkill, NY, and Burlington, Vt, from June 1989 to July 1990, and a detailed description has been published. 6 In brief, participants were women aged 15 to 44 years who were employed in manufacturing or nonmanufacturing jobs or were wives of male employees. Women who had undergone surgical sterilization or hysterectomy or whose husbands had had a vasectomy were excluded. A total of 1572 eligible participants reported 3269 pregnancies between January 1, 1980, and the date of the interview. Because previous studies showed an increased risk of subfertility and spontaneous abortion among women with exposure to glycol ether solvents in specific semiconductor manufacturing processes, 6 we excluded 104 pregnancies among women who reported such work.Retrospective data, including sociodemographic characteristics, obstetric and medical history, cigarette smoking, caffeine and alcohol consumption, and occupational information, were obtained via computerassisted interviews. Permission to review medical records was requested fr...