Inferring single-cell and spatial microRNA activity from transcriptomics data
Efrat Herbst,
Yael Mandel-Gutfreund,
Zohar Yakhini
et al.
Abstract:The activity of miRNA varies across different cell populations and systems, as part of the mechanisms that distinguish cell types and roles in living organisms and in human health and disease.
Typically, miRNA regulation drives changes in the composition and levels of protein coding RNA and of lncRNA, with targets being down-regulated when miRNAs are active.
The term "miRNA activity" is used to refer to this transcriptional effect of miRNAs.
This study introduces miTEA-HiRes, a method designed to facilitate … Show more
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