Inferior frontal white matter volume and suicidality in schizophrenia

Rüsch, Nicolas; Spoletini, Ilaria; Wilke, Marko; Martinotti, Giovanni; Bria, Pietro; Trequattrini, Alberto; Bonaviri, Giuseppina; Caltagirone, Carlo; Spalletta, Gianfranco

doi:10.1016/j.pscychresns.2007.12.011

Cited by 83 publications

(45 citation statements)

References 44 publications

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“…Other studies, however, have shown frontoparietal WM volumetric increases which were associated with severity of illness with regard to frontal WM (Lim et al, 1999). Larger inferior frontal WM volume has also been associated with suicidality and self-aggression in schizophrenia (Rüsch et al, 2008). …”

Section: Discussionmentioning

confidence: 99%

White matter volume abnormalities and associations with symptomatology in schizophrenia

Makris¹,

Seidman²,

Ahern³

et al. 2010

Psychiatry Research: Neuroimaging

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The cerebral white matter (WM) is critically involved in many bio-behavioral functions impaired in schizophrenia. However, the specific neural systems underlying symptomatology in schizophrenia are not well known. By comparing the volume of all brain fiber systems between chronic patients with DSM-III-R schizophrenia (n = 88) and matched healthy community controls (n = 40), we found that a set of a priori WM regions of local and distal associative fiber systems were significantly different in patients with schizophrenia. There were significant positive correlations between volumes (larger) in anterior callosal, cingulate and temporal deep WM regions (related to distal connections) with positive symptoms, such as hallucinations, delusions and bizarre behavior, and significant negative correlation between volumes (smaller) in occipital and paralimbic superficial WM (related to local connections) and posterior callosal fiber systems with higher negative symptoms, such as alogia. Furthermore, the temporal sagittal system showed significant rightward asymmetry between patients and controls. These observations suggest a pattern of volume WM alterations associated with symptomatology in schizophrenia that may be related in part to predisposition to schizophrenia.

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Section: Discussionmentioning

confidence: 99%

White matter volume abnormalities and associations with symptomatology in schizophrenia

Makris¹,

Seidman²,

Ahern³

et al. 2010

Psychiatry Research: Neuroimaging

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“…The last decade has seen an increasing use of neuroimaging in schizophrenia research on structural changes in the brains of patients. An association between structural changes in areas such as the left orbitofrontal and superior temporal gyrus [126], as well as in the inferior frontal volume [127], and suicidal behavior has been reported. However, more studies are needed to expand our knowledge of biological mechanisms underlying suicide in schizophrenia, and the clinical implications of these findings are yet to be investigated.…”

Section: Biomarkers Of Suicide Risk In Schizophreniamentioning

confidence: 99%

Suicide in schizophrenia

Carlborg

Winnerbäck

Jönsson

et al. 2010

Expert Review of Neurotherapeutics

113

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SchizophreniaSchizophrenia is a devastating psychiatric disorder affecting approximately 1% of the population worldwide during a lifetime. The onset of the illness occurs relatively early in life, usually in the late teens or early adulthood, and most patients have long-lasting adverse effects. Schizophrenia is a clinical syndrome diagnosed on the basis of symptom profiles, and is characterized by a constellation of symptoms of psychosis, such as abnormalities in the perception or expression of reality, as well as negative symptoms, such as affective flattening and avolition. Cognitive deficits are also usually present, and the symptoms must have persisted continuously for a least 6 months: however, schizophrenia cannot be diagnosed if symptoms of mood disorder are present or the symptoms are the direct result of a medical condition or substance abuse (Box 1) [201].The specific causes of schizophrenia are not known and combinations of several factors are likely to be involved. Genetic factors play a major role in the development of the disease [1], and environmental factors are also of importance. These latter factors include a history of obstetric complications, such as asphyxia [2] and prematurity [3]. Advanced paternal age is also considered to be a risk factor [4], and birth during the spring and late winter also increases the risk [5]. Prenatal viral infections [6], serious viral infections of the CNS during childhood [7], migrant status and urban rearing [8], and a lifetime history of cannabis use [9] are other well-known risk factors.Contrary to previous interpretations, the incidence and prevalence of schizophrenia show marked variation between sites. For example, migrants have an increased incidence and prevalence of schizophrenia, and exposures related to urbanicity, economic status and latitude are also associated with various frequency measures [10]. Men have a higher risk than women [11], and a recent review concluded that men have a 40% higher incidence of schizophrenia than women [12]. SuicideSuicide is defined as a self-inflicted death with evidence that the person intended to die (Box 2) [13]. Suicide is among the leading causes of premature death in the world and it is estimated that approximately 1 million people die by suicide every year [202]. Suicide rates vary according to region, gender, age, time and ethnic origin, and also according to death registration practices. The annual suicide rate in the world is 14.5 out of 10,0000 (in 2000), which is equal to one suicide every 40 s. Suicide is approximately three-to four-times more common in men than in women [202]. Suicide rates vary between different regions, and underestimation of suicide rates is common due to under-reporting, lack of epidemiological data and misclassification [14]. It has been estimated from psychological autopsies that more than 90% of those dying by suicide have a diagnosable psychiatric disorder at the time of death, and approximately 60% of the Schizophrenia is a disorder with an estimated suicide risk of 4-5%. Many f...

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“…Numerous other studies have corroborated fronto-temporal volume reductions in suicidal patients (Benedetti et al, 2011;Giakoumatos et al, 2013;Soloff et al, 2012;Wagner et al, 2011;Wagner et al, 2012). However, some studies investigating the whole brain of suicidal populations did not report volumetric alterations of the temporal cortex (Rusch et al, 2008;Wagner et al, 2011). Research has also shown parietooccipital volume reductions in suicidal patients with bipolar disorder (Benedetti et al, 2011), borderline personality (Soloff et al, 2012), and various psychotic disorders (Giakoumatos et al, 2013).…”

Section: Introductionmentioning

confidence: 99%