Inferences on the kinetics of asbestos deposition and clearance among chrysotile miners and millers

Finkelstein, Murray M.; Dufresne, A.

doi:10.1002/(sici)1097-0274(199904)35:4<401::aid-ajim12>3.0.co;2-4

Cited by 70 publications

(48 citation statements)

References 13 publications

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“…This may be exemplified by the figures for an insured person who had started hazardous work at the age of 20 and continued this work for 20 years. After another 40 years without any adtos which was the main type used in Germany, have a very long half-life in the human lung [29][30][31][32]. High asbestos body counts were obtained in lung tissue samples from insureds whose last asbestos exposure dated back to up to 40 years ago (Figure 3a).…”

Section: Discussionmentioning

confidence: 99%

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Feder

Theile

Tannapfel

2017

Int J Occup Med Environ Health

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Objectives: This study has researched the significance of histologically raised findings and lung dust analyses in the context of claiming the recognition of and thus compensation for an asbestos-associated occupational disease. Material and Methods: For this approach, all findings from the German Mesothelioma Register in 2015 that included lung dust analyses were evaluated and were compared with information on asbestos fiber exposure at work based on fiber years, and with the results of radiological findings. Results: For 68 insured persons, recognition of an asbestos-induced lung disease according to Section 4104 of the German Ordinance on Occupational Diseases (Berufskrankheitenverordnung -BKV) could be recommended solely on the basis of the histological examinations of lung tissues and complementary lung dust analyses. Neither did the calculation of the cumulative asbestos dust exposure at work yield 25 fiber years, nor could bridge findings (e.g., plaques) be identified. In addition, the autopsies of 12 patients revealed plaques that had not been diagnosed during radiological examinations. These results show that -irrespective of the prescribed working techniques and radiological diagnosis -pathological/anatomical and histological diagnostics are often the only way for the insureds to demonstrate the causal connection between asbestos and their disease. Even after long intervals of up to 40 years post last exposure, the asbestos fibers would still be easily detectable in the lung tissues evaluated. Conclusions: Whenever suitable tissue is available, it should be examined for mild asbestosis with the aid of a lung dust analysis. Otherwise there is a risk that an occupational disease is wrongfully rejected. In the context of health insurance, the lung dust analysis and the resulting proof of the presence of asbestosis often constitute one option of providing evidence of an occupational disease. Int J Occup Med Environ Health 2018;31(3):293 -305

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Section: Discussionmentioning

confidence: 99%

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Feder

Theile

Tannapfel

2017

Int J Occup Med Environ Health

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“…Chrysotile shows less carcinogenicity of malignant mesothelioma than crocidolite, but has nearly eaqual carcinogenicity as amosite 26,27) . Chrysotile has a quality to easily go out from the body and the content of asbestos in the lung does not always exhibit the real exposed dose of asbestos [28][29][30][31] . In our study, chrysotile was detected in 4 cases of construction workers.…”

Section: Discussionmentioning

confidence: 99%

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

et al. 2004

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Malignant pleural mesothelioma is induced by asbestos exposure. Many reports have described this situation in America and European countries, but a few have been published in Japan. In this study malignant pleural mesothelioma cases in hospitals located in an area facing the Seto Inland Sea were evaluated. A total of 106 patients were examined with 100 patients having had occupational exposure to asbestos and 6 patients without such histories of asbestos exposure. Ninety seven were male and 9 were female. Ages ranged from 41 to 87 yr with mean of 64.8 ± 5.3 yr. Thirty seven cases showed epithelial type of tumor, 25 biphasic type and 15 showed sarcomatous. The remaining 23 cases had insufficient evidence for typing the tumor. The mean survival rate for all cases was 9.2 ± 11.6 months. Fifty-one patients had occupational histories of shipyard work, 16 patients worked in asbestos cement piping, and the remainder were employed in miscellaneous jobs related asbestos exposure. The duration of asbestos exposure ranged up to 20 yr or longer with the mean of 17.2 ± 8.9 yr and the average latent period for the occurrence of malignant pleural mesothelioma was more than 31 yr with the mean of 37.0 ± 13.3 yr. Quantification of asbestos bodies in the lungs indicated a high concentration in most patients and the major types of asbestos fibers were crocidolite and amosite. Six cases appeared after exposure to chrysotile. These results indicated that ninety four percent of malignant pleural mesothelioma appeared due to the exposure to asbestos including crocidolite and amosite. The remainder may be blamed on exposure to chrysotile.

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“…Chrysotile is cleared more rapidly from the human body than amphiboles 10) . In other words, the amphiboles concentrations in lung tissue are an index that indicates the amount of accumulation from air intake over a lifetime, while the chrysotile concentration is more likely to be an index for the recent intake.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Asbestos and Non-Asbestos Fiber Concentrations in Autopsied Inhabitants in Pohang, Korea.

Lim

Kim

Saito³

et al. 2004

INDUSTRIAL HEALTH

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To establish reference values for pulmonary asbestos and non-asbestos fiber concentrations in rural Korean residents, and their comparison with those of urban Korean residents and the Japanese, autopsied lung samples from 22 subjects (20 males and 2 females), in Pohang, without known occupational asbestos exposure histories, were analyzed for asbestos and non-asbestos fibers, using transmission electron microscope equipped with an energy dispersive X-ray analyzer. Chrysotile was the major fiber type found in the lungs of the subjects. The residents in Pohang had significantly lower asbestos and non-asbestos fiber concentrations than the Korean urban residents. The Koreans had significantly lower asbestos and non-asbestos fiber concentrations than the Japanese.

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Inferences on the kinetics of asbestos deposition and clearance among chrysotile miners and millers

Cited by 70 publications

References 13 publications

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

Pulmonary Asbestos and Non-Asbestos Fiber Concentrations in Autopsied Inhabitants in Pohang, Korea.

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