Inference of the core gene regulatory network underlying seam cell development inCaenorhabditis elegans
Alicja Brożek,
Arianna Ceccarelli,
Andreas Christ Sølvsten Jørgensen
et al.
Abstract:Gene regulatory networks are fundamental in cellular decision-making, yet even in well-studied systems, their topologies are often poorly characterised. The nematodeCaenorhabditis eleganscontains a population of stem-like cells, known as seam cells. While seam cells are essential to generate the majority of the animal epidermis as well as specific neurons, the architecture of the underlying gene network has not been elucidated. Here, we combine experiments, mathematical modelling and statistical inference to u… Show more
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