Infektion

Praziquantel

“…A striking feature in the pathology of mice and monkeys infected with Sckistosoma mansoni or Sckistosoma japonicum and given curative doses of praziquantel is the rapid resolution of cellular reactions and fibrosis in tissues containing egg^.^',^^ In baboons infected with Sckistosorna kaematobium the ureters and bladders recovered their functional integrity. In vervet monkeys and rabbits infected with Schistosoma japonicum there was a similar resolution of pathology in the liver and b o~e 1 .~~,~~,~~~ Size of e g g granulomata markedly regressed in mice following curative treatment with praziquantel: within 12 weeks their diameter had been reduced to less than half (140 pm) of that of granulomata from not treated mice (340 The devolution of egg lesions appeared to be more rapid after praziquantel treatment than after treatment with either stibophen or Miracil D.38, 39 Similarly, granulomata that had been formed around the drug-affected and rapidly disintegrating Sckistosoma mansoni worms decreased from a maximal mean diameter of 900pm to one of 550 pm at 12 weeks after treatment.…”

“…72~176,179,18036 Istmiopkora m e h , another intestinal fluke, has been eliminated from rats and ferrets with single doses of 1 X 50 and 1 X 100 mglkg, respectively, and hedgehogs have been freed of their intestinal fluke Brackylaema erinacei. 3,187 The pancreatic fluke Euryfrerna coelmaticum and the liver fluke Platynosomum concinnum have been treated successfully in cattle and cats, respectively. 188,190 Nasitrerna attenuata infections in dolphins and several liver trematodes of monkeys and birds have also been treated success-Praziquantel could further become a promising drug for the treatment of the various monogenean and digenean parasites of fish.…”

“…ED,, Values o r Estimates (*)of Praziquantel for Different Host Animals and Schistosome Species (Stated as the Total Dose Administered in mglkg) (ref 3). …”

Current status of medicinal research in helminth diseases

“…It has virtually no contraindications and thus may be used both debilated and pregnant patients. 78 A number of structural analogs of niclosamide have been synthesized, many of which show marked cestodicidal activity in man and animals.% The most effective analogs of niclosamide are rafoxanide (35), oxyclozanide (36), and terenol (37), which have been found to display a wide spectrum of activity against H. nunu, H. diminutu, and Monieziu sp. in rodents and ruminants, respectively.…”