Infective endocarditis with negative blood cultures

Naber, Christoph; Erbel, Raimund

doi:10.1016/j.ijantimicag.2007.07.017

Cited by 39 publications

(28 citation statements)

References 41 publications

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“…Therefore, negative blood cultures do not exclude infection. 19 Clearance of blood cultures with antibiotics in a patient with IE, although a welcome sign, consequently cannot alone be taken as proof of cure.…”

Section: Cultures and Serologiesmentioning

confidence: 99%

Current Hypotheses in Cardiac Surgery: Biofilm in Infective Endocarditis

Elgharably

Hussain

Shrestha

et al. 2016

Seminars in Thoracic and Cardiovascular Surgery

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Section: Cultures and Serologiesmentioning

confidence: 99%

Current Hypotheses in Cardiac Surgery: Biofilm in Infective Endocarditis

Elgharably

Hussain

Shrestha

et al. 2016

Seminars in Thoracic and Cardiovascular Surgery

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“…(9) HIV infection in Africa, unlike that in the developed world, has been a major health problem in the last 20 years. HIV infection has widely affected the general population, unlike in most industrialised nations where HIV has been commonly associated with intravenous drug use and social instability.…”

Section: Introductionmentioning

confidence: 99%

Long term outcome and EuroSCORE II validation in native valve surgery for active infective endocarditis in a South African cohort

Koshy

Engel

Carrara

et al. 2018

SAHJ

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There has been little change in the mortality from infective endocarditis, despite the diagnostic and therapeutic advances made in the last 25 years. The current in-hospital mortality rate for patients with IE is 15% -20%, with 1-year mortality approaching 40%. The morbidity associated with infective endocarditis includes: valvular incompetence, embolisation, cerebrovascular accidents and congestive heart failure which have influenced the surgical approaches to a great extent. Infective endocarditis is a significant problem in sub-Saharan Africa and is related to a high prevalence of rheumatic heart disease among the young indigent population. Africa has the highest burden of rheumatic heart disease contributing 17% -43% of all heart disease.

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“…Blood culture (BC) is considered the gold standard for microbiological diagnosis of IE (Watkin et al, 2003) but in up to one third of patients with suspected IE, BC can be negative due to a number of possible factors, such as prior antimicrobial therapy, the presence of fastidious microorganisms, or a low bacterial load (Lamas & Eykyn, 2003;Naber & Erbel, 2007). Identification of pathogens from heart valve tissue by real-time PCR has been shown to be a reliable technique (Lang et al, 2004;Mencacci et al, 2011).…”

mentioning

confidence: 99%