Infective endocarditis with glomerulonephritis associated with cat chlamydia (C. psittaci) infection.

Abstract

SUMMARY A patient with glomerulonephritis and endocarditis is described who had evidence of feline Chlamydia psittaci infection. Treatment with antichlamydial drugs resulted in resolution ofthe glomerulonephritis and the endocarditis. It is recommended that screening for chlamydia is included in the investigation of patients with suspected or obscure endocarditis.Infective endocarditis is often caused by an unusual organism. The management of such cases is much more effective if the identity of the organism has been established (Friedberg, 1964;Hampton and Harrison, 1967).We describe a patient with infective endocarditis and secondary glomerulonephritis in whom there was strong evidence of infection with the feline keratoconjunctivitis agent (Chlamydia psittaci

Detection ofChlamydophila pneumoniaein cats with conjunctivitis

“…Based on the small number of C. felis ‐positive samples, it was not possible to make an accurate statement about the correlation of gender, housing, vaccination status, and age with positive results, but findings are in agreement with previously published literature 1–3,15,17,19,26,27,32 . The zoonotic potential of C. felis is known, and transmission from cats to human beings is well documented 20–26 …”

“…[1][2][3]15,17,19,26,27,32 The zoonotic potential of C. felis is known, and transmission from cats to human beings is well documented. [20][21][22][23][24][25][26] Three cats tested positive for chlamydia related to uncultured Chlamydiales by sequence analysis (common term for Chlamydiae that have not been cultivable in a growth medium so far, but detectable solely using PCR sequence analysis). Interestingly, one of these positive cats was also infected with C. pneumoniae and showed clinical symptoms of conjunctivitis and diarrhea.…”

Detection ofChlamydophila pneumoniaein cats with conjunctivitis

“…Based on the small number of C. felis ‐positive samples, it was not possible to make an accurate statement about the correlation of gender, housing, vaccination status, and age with positive results, but findings are in agreement with previously published literature 1–3,15,17,19,26,27,32 . The zoonotic potential of C. felis is known, and transmission from cats to human beings is well documented 20–26 …”

“…[1][2][3]15,17,19,26,27,32 The zoonotic potential of C. felis is known, and transmission from cats to human beings is well documented. [20][21][22][23][24][25][26] Three cats tested positive for chlamydia related to uncultured Chlamydiales by sequence analysis (common term for Chlamydiae that have not been cultivable in a growth medium so far, but detectable solely using PCR sequence analysis). Interestingly, one of these positive cats was also infected with C. pneumoniae and showed clinical symptoms of conjunctivitis and diarrhea.…”

A case of renal involvement in persistent immune activation caused by chlamydial salpingitis

“…As for C. psittasi, which is the same Chlamydia genus, some case reports have noted the occurrence of nephropathy after an acute respiratory organ infection and endocarditis [4,9,11,12,16]. In these cases, the renal histology showed interstitial nephritis, acute tubular necrosis, and mesangial or endocapillary proliferative glomerulonephritis.…”

Tracheal botryomycosis in a patient with tracheopathia osteochondroplastica

“…Grif®ths et al reported a case of general malaise, cough, and abnormal liver function due to the feline serovar of C psittaci in an immunosuppressed woman, 9 and Regan et al reported a case of endocarditis with associated glomerulonephritis in a 40 year old man. 10 Both cases reported close contact with cats. The subsequent death of the second case from pneumonia of an unknown aetiology raises the possibility of unrecognised immune de®ciency in that case.…”

Detection ofChlamydophila pneumoniaein cats with conjunctivitis

“…Based on the small number of C. felis ‐positive samples, it was not possible to make an accurate statement about the correlation of gender, housing, vaccination status, and age with positive results, but findings are in agreement with previously published literature 1–3,15,17,19,26,27,32 . The zoonotic potential of C. felis is known, and transmission from cats to human beings is well documented 20–26 …”

“…[1][2][3]15,17,19,26,27,32 The zoonotic potential of C. felis is known, and transmission from cats to human beings is well documented. [20][21][22][23][24][25][26] Three cats tested positive for chlamydia related to uncultured Chlamydiales by sequence analysis (common term for Chlamydiae that have not been cultivable in a growth medium so far, but detectable solely using PCR sequence analysis). Interestingly, one of these positive cats was also infected with C. pneumoniae and showed clinical symptoms of conjunctivitis and diarrhea.…”

A case of renal involvement in persistent immune activation caused by chlamydial salpingitis

“…As for C. psittasi, which is the same Chlamydia genus, some case reports have noted the occurrence of nephropathy after an acute respiratory organ infection and endocarditis [4,9,11,12,16]. In these cases, the renal histology showed interstitial nephritis, acute tubular necrosis, and mesangial or endocapillary proliferative glomerulonephritis.…”

Tracheal botryomycosis in a patient with tracheopathia osteochondroplastica

“…Grif®ths et al reported a case of general malaise, cough, and abnormal liver function due to the feline serovar of C psittaci in an immunosuppressed woman, 9 and Regan et al reported a case of endocarditis with associated glomerulonephritis in a 40 year old man. 10 Both cases reported close contact with cats. The subsequent death of the second case from pneumonia of an unknown aetiology raises the possibility of unrecognised immune de®ciency in that case.…”

Detection ofChlamydophila pneumoniaein cats with conjunctivitis

“…Based on the small number of C. felis ‐positive samples, it was not possible to make an accurate statement about the correlation of gender, housing, vaccination status, and age with positive results, but findings are in agreement with previously published literature 1–3,15,17,19,26,27,32 . The zoonotic potential of C. felis is known, and transmission from cats to human beings is well documented 20–26 …”

“…[1][2][3]15,17,19,26,27,32 The zoonotic potential of C. felis is known, and transmission from cats to human beings is well documented. [20][21][22][23][24][25][26] Three cats tested positive for chlamydia related to uncultured Chlamydiales by sequence analysis (common term for Chlamydiae that have not been cultivable in a growth medium so far, but detectable solely using PCR sequence analysis). Interestingly, one of these positive cats was also infected with C. pneumoniae and showed clinical symptoms of conjunctivitis and diarrhea.…”

A case of renal involvement in persistent immune activation caused by chlamydial salpingitis

“…As for C. psittasi, which is the same Chlamydia genus, some case reports have noted the occurrence of nephropathy after an acute respiratory organ infection and endocarditis [4,9,11,12,16]. In these cases, the renal histology showed interstitial nephritis, acute tubular necrosis, and mesangial or endocapillary proliferative glomerulonephritis.…”

Tracheal botryomycosis in a patient with tracheopathia osteochondroplastica

“…Grif®ths et al reported a case of general malaise, cough, and abnormal liver function due to the feline serovar of C psittaci in an immunosuppressed woman, 9 and Regan et al reported a case of endocarditis with associated glomerulonephritis in a 40 year old man. 10 Both cases reported close contact with cats. The subsequent death of the second case from pneumonia of an unknown aetiology raises the possibility of unrecognised immune de®ciency in that case.…”