Infective endocarditis in French Polynesia: Epidemiology, treatments and outcomes

Blanchard, Virginie; Pagis, Bruno; Richaud, Rainui; Moronval, Frederic; Lutinier, Renaud; Gallais, Katell; Goanvic, Christophe Le; Fontán, A; Girardot, Sylvain; Ah-Kang, Florence; Atger, Olivier; Iung, Bernard; Lavie-Badie, Yoan

doi:10.1016/j.acvd.2019.12.007

Cited by 12 publications

(12 citation statements)

References 26 publications

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“…Complications of IE were defined as follows: septic shock (the presence of an acute circulatory failure in sepsis, characterized by persistent arterial hypotension—ie, systolic pressure < 90 mmHg despite adequate volume resuscitation); embolic events, including intracranial complications (eg, hemorrhage and infarction) and peripheral embolic events mainly characterized by splenomegaly or splenic embolism; functional class III–IV in accordance with the New York Heart Association (NYHA) classification; atrial fibrillation (a common arrhythmia in patients with acute conditions attributed to inflammation and hemodynamic change). 6 , 12 , 13 …”

Section: Methodsmentioning

confidence: 99%

“… 5 The epidemiological characteristics of IE have recently changed owing to the evolution of medical practice and demographic changes. 6 Moreover, the incidence of IE in elderly patients has increased because of the aging general population and the increased proportion of comorbidities. 4 , 7 , 8 Age is currently included as a predictor in several risk scores and is regarded as an important independent predictor of mortality in patients with IE.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study

Zhang¹,

Jin²,

Lu³

et al. 2022

IDR

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Purpose This study aimed (i) to investigate the clinical characteristics and risk factors related to in-hospital mortality in patients with infective endocarditis (IE) and (ii) to compare the differences in three age groups. Methods A total of 240 IE cases diagnosed using the modified Duke criteria between January 2016 and December 2019 were included and retrospectively studied. Patients were stratified into three age groups: < 50 y, 50–65 y, and > 65 y. Results The mean age of the patients was 51 ± 14 y, and 154 patients (64.2%) were male. In addition, 136 (56.7%) patients with IE had no previous cardiac disease. Congenital heart disease (CHD, 21.3%) was the most common underlying heart disease, followed by rheumatic heart disease (RHD, 8.8%). Streptococcus was found in 55 (22.9%) patients and was the most common causative pathogen, comprising 52.9% of all positive blood cultures. Echocardiography showed the presence of vegetations in 88.3% of cases and the predominant involvement of the left heart valves. Fever and cardiac murmur were the most frequent presentations, with no significant differences among age groups. Compared with younger patients, elderly patients had a lower operation rate and higher in-hospital mortality. The independent risk factors of in-hospital mortality were age > 65 y, intracranial infection, splenic embolization, cerebral hemorrhage, NYHA class III–IV, and prosthetic valve infection. Conclusion CHD replaces RHD as the most common underlying heart disease in IE patients. Patients without previous cardiac disease are at increased risk of IE. Streptococcus is still the primary causative pathogen of IE. Elderly patients present with more comorbidities and complications, in addition to a more severe prognosis than younger patients. Age older than 65 y, intracranial infection, splenic embolization, cerebral hemorrhage, NYHA class III–IV, and prosthetic valve infection showed poorer in-hospital outcomes.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study

Zhang¹,

Jin²,

Lu³

et al. 2022

IDR

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“…Moreover, yeasts have already been reported in the dental pulp despite previous decontamination of the manipulated tooth and the presence of antifungal in the culture medium [14]. E. faecium isolated in two of three teeth under at least two rapid culturomics conditions is one of the most prevalent pathogens responsible for IE [7,15]. Its detection in the patient reported on here may result from past E. faecium bacteraemia.…”

Section: Discussionmentioning

confidence: 77%

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…”

mentioning

confidence: 99%

Detection of Staphylococcus aureus in the Pulp of an Endocarditis Patient

Terrer

2020

MRD

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previously but who was not longer bacteraemic when the tooth was extracted [1]. Infectious endocarditis (IE) is mainly caused by streptococci, staphylococci and enterococci and, rarely, by fungi [7,8]. Staphylococcus aureus (S. aureus) is one of the pathogens most frequently involved in blood-borne infections, including IE [9,10]. In this paper, we report on one patient diagnosed with S. aureus endocarditis in whom S. aureus DNA was further detected by PCR in the dental pulp. MaterialsIn April 2019, a 54-year-old patient was admitted to the emergency department of the Timone hospital (Marseille, France) with fever, confusion and tetraparesia. A cerebral scan

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“…An example of islands at significant distances from mainland cardiac centers are the French Polynesian Islands which include Bora Bora and Tahiti. These South Pacific Ocean islands air-bridge cardiac surgical patients to either New Zealand (4100 km away) or Paris, France (15,700 km away) [16]. In a study by Gallandt and colleagues, an average residential distance of 44.2 miles from an LVAD implant center did not affect mortality, complications, nor quality of life following implant [17].…”

Section: Impact Of Distance From An Implant Centermentioning

confidence: 99%

Destination left ventricular assist devices in island states: asking too much or the inevitable solution

et al. 2022

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Background Destination left ventricular assist device placement is increasing as a result of donor shortages and changing patient attitudes. As organ shortages become critical, LVAD programs become fundamental even in more remote regions of the world including island states. Here, we provide a look into the current state and availability of LVAD programs in island states. Main body A narrative review was performed using the World Health Organization Global Index Medicus and PubMed/MEDLINE databases to identify articles describing the island states having reported LVAD placements and programs. Additionally, INTERMACS reports were used. Data were retrieved and a review is presented describing the current state of LVADs in island states. The Caribbean region as a whole has a heart failure (HF) prevalence of 814 per 100,000 and Oceania 667 per 100,000 people. We estimate that over 3000 people in these islands need either a heart transplant or an LVAD. Short conclusion For HF patients living in island regions, special attention should be paid to the inability of having access to specialized mainland medical care. The continuous quest for a solution to HF in island regions should include the establishing of high-quality LVAD programs in a transfer-network centralized/regionalized system to care for those patients not candidates for long-distance air-bridging.

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Infective endocarditis in French Polynesia: Epidemiology, treatments and outcomes

Cited by 12 publications

References 26 publications

Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study

Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study

Detection of Staphylococcus aureus in the Pulp of an Endocarditis Patient

Destination left ventricular assist devices in island states: asking too much or the inevitable solution

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