Infective endocarditis in children: native valve preservation is frequently possible despite advanced clinical disease

Hickey, Edward; Jung, G.W.; Manlhiot, Cedric; Sakopoulos, Andreas G.; Caldarone, Christopher A.; Coles, John G.; Arsdell, Glen S. Van; McCrindle, Brian W.

doi:10.1016/j.ejcts.2008.08.020

Cited by 41 publications

(35 citation statements)

References 17 publications

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“…24,110,111 This may be attributable in part to the proliferation of intravascular catheters, as well as the nonspecificity of the Duke criteria in children causing false-positive diagnoses. Almost all staphylococci are highly resistant to penicillin G and ampicillin.…”

Section: Staphylococcal Endocarditis On Native Valves or Prosthetic Mmentioning

confidence: 99%

“…159,160 Depending on the degree of valve or great vessel root damage, valvesparing operations are often possible. 110,152,161 In some circumstances, cardiological evaluation may suggest a need for early surgical therapy, performed even before sterilization of blood. In a recent 15-year review of children treated for IE at the Texas Heart Institute in Houston, TX, early surgery was performed in 61% of patients, with most of these surgeries occurring within 7 days and half within 3 days of diagnosis.…”

Section: Indications For Surgerymentioning

confidence: 99%

“…24,110,111 Penicillin-susceptible streptococci are those with an MIC of ≤0.1 μg of penicillin per milliliter. In patients with IE caused by penicillin-susceptible streptococci who are able to tolerate a β-lactam antibiotic, 2 therapeutic regimens are associated with high cure rates ( Table 7) and include penicillin G and ceftriaxone.…”

Section: Native Cardiac Valvesmentioning

confidence: 99%

See 2 more Smart Citations

Infective Endocarditis in Childhood: 2015 Update

Baltimore¹,

Gewitz²,

Baddour³

et al. 2015

Circulation

308

238

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Section: Staphylococcal Endocarditis On Native Valves or Prosthetic Mmentioning

confidence: 99%

Section: Indications For Surgerymentioning

confidence: 99%

Section: Native Cardiac Valvesmentioning

confidence: 99%

See 1 more Smart Citation

Infective Endocarditis in Childhood: 2015 Update

Baltimore¹,

Gewitz²,

Baddour³

et al. 2015

Circulation

308

238

View full text Add to dashboard Cite

“…Hickey et al (6) have indicated that native valve preservation should be preferred in the children with IE. Though valve replacement confers to a high risk of repeat replacement at the 15 th year (7), valve replacement is necessary in many Chinese children with IE because either they come to hospital with advanced clinical manifestations or their valves are damaged too severely where preservation of the values is not a feasible option.…”

Section: Original Articlementioning

confidence: 99%

A 20-year study on treating childhood infective endocarditis with valve replacement in a single cardiac center in China

et al. 2016

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Background: Children with infective endocarditis (IE) have to undergo valve replacement instead of valve repair in China due to severe valve damage. The present study is to review our experience on surgical treatment of children with IE in reference to the incidence, pathologic status, diagnosis, surgical strategies and outcomes. Methods: We reviewed 35 patients with a mean age of 13.7±2.2 years who were underwent valve replacement surgery for IE during the period from January 1993 to December 2013. Preoperative transthoracic echocardiographic (TTE) evaluation and transesophageal echocardiography during operation were performed in all patients. All the children underwent chart review and retrospective risk-hazard analysis. Results: Among the patients surveyed congenital cardiac lesions were present in 15 (42.8%), rheumatic heart valve disease in 2 (5.7%) and previous heart surgery in 2 (5.7%). The median stay of intensive care unit was 6 days. Intraoperative findings showed that the endocarditis involved mostly the mitral and aortic valves (88.5%). Triple or quadruple valve involvement was found in one patient each. Ten-year freedom from IE-related death and re-intervention was 94.2% and 91.6%, respectively. Conclusions: Children undergoing surgery for IE frequently have advanced disease with embolic complications. Although valve replacement is not the primary option for pediatric IE, the rate of 5-year survival and freedom from re-operation was optimal prognostically. Pediatric physicians should pay attention to the common clinical features of IE so that the native valve is preserved well.

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“…2,12 Infective endocarditis can occur in children without previously cardiac defects in 20% cases. 13,14 Rightsided IE rarely occurs with 5-10% incidence from all cases, especially in HIV or immunosuppresed patients. Infections related with low sterility of intravenous (IV) injection, contaminated IV drugs, and immunity abnormalities.…”

mentioning

confidence: 99%

Infective Endocarditis in a ?-thalassemia Major Child

et al. 2015

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Almost all patients who develop infective endocarditis (IE) had history of congenital or acquired heart disease.We report a 9 years old boy who was diagnosed as ?-thalassemia major since age 1.5 years, admitted to hospital with chief complaint of difficulty of breathing for 1 week before admission, accompanied by fever. Holosystolic murmur of grade 3/6 was found in the lower left sternal border along with hepatosplenomegaly. Chest x-ray depicted right ventricle enlargement and opaque densities in the middle field of left lung. Blood culture showed growth of Staphylococcus aureus. Echocardiography detected thickening tricuspid valve with oscillating mass in the tricuspid valve, severe pulmonary hypertension, and minimal pericardial effusion. Diagnosis of IE was made. After clinical improvement he was discharged with good condition. The diagnosis of IE in children without heart defects is difficult to establish and right-sided IE is rare in children that a high suspicion index should be considered. DOI: http://dx.doi.org/10.3329/cardio.v7i2.22263 Cardiovasc. j. 2015; 7(2): 145-149

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Infective endocarditis in children: native valve preservation is frequently possible despite advanced clinical disease

Cited by 41 publications

References 17 publications

Infective Endocarditis in Childhood: 2015 Update

Infective Endocarditis in Childhood: 2015 Update

A 20-year study on treating childhood infective endocarditis with valve replacement in a single cardiac center in China

Infective Endocarditis in a ?-thalassemia Major Child

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