Infective Endocarditis Due to Bact. faecalis alcaligenes

Cole, A. C. E.; Marshall, Caroline

doi:10.1136/bmj.2.4789.867

Cited by 20 publications

(8 citation statements)

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“…A. faecalis infection cases ( Table 5) Table 5 Alcaligenes faecalis infection cases To our knowledge, sixty-two A. faecalis infection cases were sporadically reported in the medical literature before 1997 [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. The most commonly reported cases involved bacteremia and meningitis, and most cases occurred in newborns and infants.…”

Section: Discussionmentioning

confidence: 99%

“…Inappropriate and inadequate infection control strategies may be the cause of A. faecalis meningitis and A. faecalis bacteremia in high-risk newborns and infants. In 1960, Doxiadis reported 33 cases of bacteremia in newborns, which was the largest cases series before 1997 [36]. A. faecalis was resistant to sulfonamides, and there were 20 deaths due to A. faecalis bacteremia.…”

Section: Discussionmentioning

confidence: 99%

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Extensively Drug-Resistant Alcaligenes Faecalis Infection

Huang¹

2020

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Background: Alcaligenes faecalis is usually opportunistic infection in humans. Alcaligenes faecalis infection is often challenging to treat due to its increased resistance to many antibiotics. The results from a clinical study of Alcaligenes faecalis infection may help improve patients’ clinical care.Methods: We conducted a retrospective analysis of all patients presenting with Alcaligenes faecalis infection from January 2014 through December 2019. The medical records of all patients were reviewed for demographic information, clinical symptoms and signs, comorbidities, use of intravenous antibiotics within the past 3 months, bacterial culture, antibiotics sensitivity test, and clinical outcomes.Results: Sixty-one cases of Alcaligenes faecalis infection were seen during the study period, including 25 cases of urinary tract infection, 9 cases of diabetic foot ulcer with infection, 8 cases of pneumonia, 7 cases of acute pyelonephritis, 3 cases of bacteremia, 9 cases of infection at other sites. Thirty-four patients (55.7%) had a history of receiving intravenous antibiotics within 3 months of the diagnosis. Fifty-one (81.9%) cases involved polymicrobial infections. Extensive drug-resistant infections have been reported since 2018. The highest antibiotic sensitivity rate for Alcaligenes faecalis, 75%, was reported from 2018 to 2019. Ciprofloxacin, piperacillin/tazobactam, amikacin, and cefepime are not good choices for empiric therapy of Alcaligenes faecalis infection.Conclusions: The most frequent Alcaligenes faecalis infection sites were in the urinary tract, skin and soft tissue, and lung. Most cases were polymicrobial infections. Alcaligenes faecalis showed markedly deceasing sensitivity to commonly used antibiotics and, more recently, extensive drug-resistant Alcaligenes faecalis infections have emerged.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extensively Drug-Resistant Alcaligenes Faecalis Infection

Huang¹

2020

Preprint

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“…To our knowledge, there were 130 sporadically reported cases of A. faecalis infection in the literature (table 7) [1,2,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. The most commonly reported cases involved bacteremia, and most cases occurred in newborns and infants.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Extensively drug-resistant Alcaligenes faecalis infection

Huang

2020

Preprint

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Background: Alcaligenes faecalis is usually opportunistic infection in humans. Alcaligenes faecalis infection is often challenging to treat due to its increased resistance to many antibiotics. The results from a clinical study of Alcaligenes faecalis infection may help improve patients’ clinical care. Methods: We conducted a retrospective analysis of all patients presenting with Alcaligenes faecalis infection from January 2014 through December 2019. The medical records of all patients were reviewed for demographic information, clinical symptoms and signs, comorbidities, use of intravenous antibiotics within the past 3 months, bacterial culture, antibiotics sensitivity test, and clinical outcomes. Results: Sixty-one cases of Alcaligenes faecalis infection were seen during the study period, including 25 cases of cystitis, 9 cases of diabetic foot ulcer with infection, 8 cases of pneumonia, 7 cases of acute pyelonephritis, 3 cases of bacteremia, 9 cases of infection at specific sites. Thirty-seven patients (60.7%) had a history of receiving intravenous antibiotics within 3 months of the diagnosis. Fifty-one (83.6%) cases were mixed with other bacterial infections. Extensively drug-resistant infections have been reported since 2018. The best sensitivity rate to A. faecalis was 66.7% for three antibiotics (imipenem, meropenem, and ceftazidime) in 2019. Two antibiotics (ciprofloxacin and piperacillin/tazobactam) sensitivity rates to A. faecalis were less than 50%. Conclusions: The most frequent Alcaligenes faecalis infection sites were in the bloodstream, urinary tract, skin and soft tissue, and middle ear. Alcaligenes faecalis showed markedly decreased sensitivity to commonly used antibiotics and, more recently, extensively drug-resistant Alcaligenes faecalis infections have emerged.

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“…Sixty-two A. faecalis infection cases were sporadically reported in the medical literature before 1997 (Table 7) [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. The most commonly reported cases involved bacteremia and meningitis, and most cases occurred in newborns and infants.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Extensively drug-resistant Alcaligenes faecalis infection

Huang¹

2020

Preprint

View full text Add to dashboard Cite

Background: Alcaligenes faecalis is usually opportunistic infection in humans. Alcaligenes faecalis infection is often challenging to treat due to its increased resistance to many antibiotics. The results from a clinical study of Alcaligenes faecalis infection may help improve patients’ clinical care. Methods: We conducted a retrospective analysis of all patients presenting with Alcaligenes faecalis infection from January 2014 through December 2019. The medical records of all patients were reviewed for demographic information, clinical symptoms and signs, comorbidities, use of intravenous antibiotics within the past 3 months, bacterial culture, antibiotics sensitivity test, and clinical outcomes.Results: Sixty-one cases of Alcaligenes faecalis infection were seen during the study period, including 25 cases of cystitis, 9 cases of diabetic foot ulcer with infection, 8 cases of pneumonia, 7 cases of acute pyelonephritis, 3 cases of bacteremia, 9 cases of infection at specific sites. Thirty-seven patients (60.7%) had a history of receiving intravenous antibiotics within 3 months of the diagnosis. Fifty-one (83.6%) cases were mixed with other bacterial infections. Extensively drug-resistant infections have been reported since 2018. The highest antibiotic sensitivity rate for Alcaligenes faecalis, 66.7%, was reported in 2019. Ciprofloxacin and piperacillin/tazobactam are not good choices for empiric therapy of Alcaligenes faecalis infection. Conclusions: The most frequent Alcaligenes faecalis infection sites were in the urinary tract, skin and soft tissue, and lung. Alcaligenes faecalis showed markedly decreased sensitivity to commonly used antibiotics and, more recently, extensively drug-resistant Alcaligenes faecalis infections have emerged.

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Infective Endocarditis Due to Bact. faecalis alcaligenes

Cited by 20 publications

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Extensively Drug-Resistant Alcaligenes Faecalis Infection

Extensively Drug-Resistant Alcaligenes Faecalis Infection

Extensively drug-resistant Alcaligenes faecalis infection

Extensively drug-resistant Alcaligenes faecalis infection

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