Infective endocarditis caused by Granulicatella adiacens

Shailaja, T.S.; Sathiavathy, KA; Unni, Govindan

doi:10.1016/j.ihj.2013.06.014

Cited by 32 publications

(31 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, it was reported that specific Bifidobacterium strains could attenuate liver injury by downregulating the cytokines through modulating Flavonifractor . The other enriched gut microbe, Granulicatella, was originally known as a nutritional variant of Streptococcus and commonly reported to cause infective endocarditis . It was also shown to exhibit a positive association with severe diarrhoea .…”

Section: Discussionmentioning

confidence: 99%

The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients

et al. 2019

View full text Add to dashboard Cite

Pemphigus vulgaris (PV) is an autoimmune disease characterized by the production of IgG autoantibodies owing to an imbalance in the Th1/Th2 and Th17/Tregs cell pathways. The role of gut microbiota in the development of immune system and autoimmune diseases has been unraveled in the last two decades. However, data pertaining to gut microbiota of PV patients is largely lacking. We aimed to compare the gut microbiota of PV patients and healthy controls and assessed potential correlation with circulating cytokines of Th1/Th2/Th17 cell. Faecal bacterial diversity was analysed in 18 PV patients and 14 age‐ and gender‐matched healthy individuals using hypervariable tag sequencing of the V3‐V4 region of the 16S rRNA gene. Plasma levels of 20 inflammatory cytokines were assessed using the Luminex screening system. As a result, we identified 10 differentially abundant taxa between patients and controls. At the genera level, Lachnospiracea_incertae_sedis and Coprococcus decreased, while Granulicatella, Flavonifractor enriched in PV. Plasma levels of C5a, interleukin (IL)‐2R, IL‐6, IL‐8, IL‐7, IL‐1β, IL17A, IL‐5 and IL‐21 were significantly increased in PV Flavonifractor exhibited a positive correlation with C5a, IL‐6, IL‐8, IL‐7, IL‐1β, IL17A and IL‐21. Lachnospiracea_incertae_sedis and Coprococcus showed a negative correlation with IL‐17A. Our results are consistent with the hypothesis that PV patients have gut microbial dysbiosis which might contribute to the immune disorder and the development of PV.

show abstract

Section: Discussionmentioning

confidence: 99%

The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients

et al. 2019

View full text Add to dashboard Cite

show abstract

“…OTU‐3 showed a 98% sequence identity to Granulicatella adiacens , a member of the family Carnobacteriaceae that is particularly abundant in the oral cavity and the gastrointestinal tract of humans. This bacterium has consistently been associated with invasive infections in humans and considered as an opportunistic pathogen carrying resistance to β‐lactams, tetracyclines, macrolides and fluoroquinolones (Cargill, Scott, Gascoyne‐Binzi, & Sandoe, ; Gardenier, Hranjec, Sawyer, & Bonatti, ; Shailaja, Sathiavathy, & Unni, ). OTU‐4 showed high sequence identity to Acinetobacter haemolyticus (98.5%).…”

Section: Discussionmentioning

confidence: 99%

“…This bacterium has consistently been associated with invasive infections in humans and considered as an opportunistic pathogen carrying resistance to b-lactams, tetracyclines, macrolides and fluoroquinolones (Cargill, Scott, Gascoyne-Binzi, & Sandoe, 2012;Gardenier, Hranjec, Sawyer, & Bonatti, 2011;Shailaja, Sathiavathy, & Unni, 2013). OTU-4 showed high sequence identity to Acinetobacter haemolyticus (98.5%).…”

Section: Effect Of Pollution On the Streambed Resistomementioning

confidence: 99%

Wastewater pollution differently affects the antibiotic resistance gene pool and biofilm bacterial communities across streambed compartments

et al. 2017

View full text Add to dashboard Cite

Wastewater discharges introduce antibiotic residues and antibiotic-resistant bacteria (ARB) into surface waters. Both inputs directly affect the streambed resistome, either by exerting a selective pressure that favour the proliferation of resistant phenotypes or by enriching the resident communities with wastewater-associated ARB. Here, we investigated the impact of raw and treated urban wastewater discharges on epilithic (growing on rocks) and epipsammic (growing on sandy substrata) streambed biofilms. The effects were assessed by comparing control and impact sites (i) on the composition of bacterial communities; (ii) on the abundance of twelve antibiotic resistance genes (ARGs) encoding resistance to β-lactams, fluoroquinolones, sulphonamides, tetracyclines, macrolides and vancomycin, as well as the class 1 integron-integrase gene (intI1); (iii) on the occurrence of wastewater-associated bacteria, including putative pathogens, and their potential linkage to target ARGs. We measured more pronounced effects of raw sewage than treated wastewater at the three studied levels. This effect was especially noticeable in epilithic biofilms, which showed a higher contribution of wastewater-associated bacteria and ARB than in epipsammic biofilms. Comparison of correlation coefficients obtained between the relative abundance of both target ARGs and operational taxonomic units classified as either potential pathogens or nonpathogens yielded significant higher correlations between the former category and genes intI1, sul1, sul2 and ermB. Altogether, these results indicate that wastewater-associated micro-organisms, including potential pathogens, contribute to maintain the streambed resistome and that epilithic biofilms appear as sensitive biosensors of the effect of wastewater pollution in surface waters.

show abstract

“…In most of the cases we reviewed, NVS were isolated from automated culture bottles. [5][6][7][8][9] However, on subculture from these positive bottles growth is generally either delayed or/and very faint. Colonies can be identified by satellitism around colonies of Staphylococcus aureus, typical Gram stain picture of pleomorphism and increased growth on thiol containing media.…”

Section: Discussionmentioning

confidence: 99%

Granulicatella adiacens abscess: Two rare cases and review

et al. 2018

View full text Add to dashboard Cite

Granulicatella adiacens is a nutritionally variant streptococcus species. These bacteria are rarely isolated in the laboratory due to their fastidious growth requirements. These have been mostly reported from bloodstream infections, infective endocarditis, infections of orbit, nasolacrimal duct and breast implants. Here, we are reporting two cases of subcutaneous abscesses caused by G. adiacens. In first case, it was isolated from abscess around elbow joint and second case was a suprapatellar abscess. We have also reviewed the published data concerning diagnosis and antimicrobial susceptibility pattern of Granulicatella infections and included some Indian cases.

show abstract

Infective endocarditis caused by Granulicatella adiacens

Cited by 32 publications

References 6 publications

The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients

The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients

Wastewater pollution differently affects the antibiotic resistance gene pool and biofilm bacterial communities across streambed compartments

Granulicatella adiacens abscess: Two rare cases and review

Contact Info

Product

Resources

About