Infective endocarditis: an epidemiological review of 128 episodes

Dyson, C.; Barnes, Rosemary Ann; Harrison, G.

doi:10.1016/s0163-4453(99)90074-9

Cited by 77 publications

(63 citation statements)

References 23 publications

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“…5 In a UK survey of IE in adults with cardiovascular disease, including 27% with CHD, conducted between 1987 and 1996, Streptococcus species comprised 49% and Staphylococcus species comprised 26%. 6 In contrast, a US study reported that Staphylococcus species caused 50% of all episodes of IE in pediatric patients, followed by Streptococcus species in 22%. 1 The results of the present study are similar to those in previous reports from Japan and the UK studies, but different from the US study, and the discrepancy may be related to patient age, type of CHD and type of preventive measures.…”

Section: Microorganismsmentioning

confidence: 93%

Causative Organism Influences Clinical Profile and Outcome of Infective Endocarditis in Pediatric Patients and Adults With Congenital Heart Disease

Ishiwada

Niwa

Tateno

et al. 2005

Circ J

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Background Studies on microorganisms in a large cohort of patients with congenital heart disease (CHD) and infective endocarditis (IE) are rare. Using a nationwide survey, the relationship between causative microorganisms and clinical profiles in patients with CHD and IE was investigated. Methods and ResultsData from 188 patients with CHD (pediatric patients (n=113), mean age, 6.2±4.9 years; adult patients (n=75), mean age 28.4±13.4 years) and IE from 60 institutions were analyzed. Causative microorganisms were Streptococcus species (94:50.0%), Staphylococcus species (68:36.2%), Haemophilus species (9:4.8%), Candida (5:2.7%), Pseudomonas species (4:2.1%) and other unclassified microorganisms (8:4.3%). Staphylococcal IE was observed significantly higher in perioperative IE (11/16), in cyanotic patients (32/73) and patients younger than 1 year old (11/16). Streptococcal IE was observed significantly higher in acyanotic patients (64/109) and patients aged 16 years or older (48/75). Total mortality was 20/188 (10.6%) and was high for candidial (2/5; 40%) and pseudomonal IE (2/4; 50%). Mortality was highly associated with younger age, especially infants (5/16), and methicillin-resistant staphylococcal IE (6/15). Conclusions The causative microorganisms are significantly related to the clinical profile and outcome in patients with IE and CHD. These results form the basis for selecting appropriate antibiotics for prevention and management. (Circ J 2005; 69: 1266 -1270

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Section: Microorganismsmentioning

confidence: 93%

Causative Organism Influences Clinical Profile and Outcome of Infective Endocarditis in Pediatric Patients and Adults With Congenital Heart Disease

Ishiwada

Niwa

Tateno

et al. 2005

Circ J

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“…As a model we choose S. sanguinis, a member of the S. sanguinis group, and one of the causative agents of endocarditis (33)(34)(35).…”

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confidence: 99%

Heterologous Expression of sahH Reveals That Biofilm Formation Is Autoinducer-2-independent in Streptococcus sanguinis but Is Associated with an Intact Activated Methionine Cycle

Redanz

Standar

Podbielski

et al. 2012

Journal of Biological Chemistry

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Background: AI-2 is a by-product of the LuxS-mediated reaction within the activated methionine cycle (AMC). Results:The biofilm phenotype of a S. sanguinis luxS mutant was restored by SahH expression but not by AI-2 supplementation. Conclusion:The luxS mutant biofilm phenotype is not caused by lacking AI-2 but by an AMC defect. Significance: The SahH bypass is essential for further studies on AI-2 utilizing luxS mutants.

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“…14 The other organisms were not the common ones associated with infective endocarditis. 15 It is worth noting that strict aseptic measures were adopted in preparing the operative site in all patients. Povidone-iodine reduces conjunctival bacterial flora by 91 % when applied to the eye just before surgery, 16 and a definite synergistic effect is observed when applied in conjunction with a topical antibiotic.…”

Section: Discussionmentioning

confidence: 99%

Low frequency of bacteraemia during eye surgery obviates the need for endocarditis prophylaxis

Venugopalan

Ganesh

Rafay

et al. 2001

Eye

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Infective endocarditis: an epidemiological review of 128 episodes

Cited by 77 publications

References 23 publications

Causative Organism Influences Clinical Profile and Outcome of Infective Endocarditis in Pediatric Patients and Adults With Congenital Heart Disease

Causative Organism Influences Clinical Profile and Outcome of Infective Endocarditis in Pediatric Patients and Adults With Congenital Heart Disease

Heterologous Expression of sahH Reveals That Biofilm Formation Is Autoinducer-2-independent in Streptococcus sanguinis but Is Associated with an Intact Activated Methionine Cycle

Low frequency of bacteraemia during eye surgery obviates the need for endocarditis prophylaxis

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